Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2VAT

Crystal structure of deacetylcephalosporin C acetyltransferase in complex with coenzyme A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004414	molecular_function	homoserine O-acetyltransferase activity
A	0009058	biological_process	biosynthetic process
A	0009086	biological_process	methionine biosynthetic process
A	0009092	biological_process	homoserine metabolic process
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
A	0017000	biological_process	antibiotic biosynthetic process
A	0033813	molecular_function	deacetylcephalosporin-C acetyltransferase activity
B	0004414	molecular_function	homoserine O-acetyltransferase activity
B	0009058	biological_process	biosynthetic process
B	0009086	biological_process	methionine biosynthetic process
B	0009092	biological_process	homoserine metabolic process
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
B	0017000	biological_process	antibiotic biosynthetic process
B	0033813	molecular_function	deacetylcephalosporin-C acetyltransferase activity
C	0004414	molecular_function	homoserine O-acetyltransferase activity
C	0009058	biological_process	biosynthetic process
C	0009086	biological_process	methionine biosynthetic process
C	0009092	biological_process	homoserine metabolic process
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
C	0017000	biological_process	antibiotic biosynthetic process
C	0033813	molecular_function	deacetylcephalosporin-C acetyltransferase activity
D	0004414	molecular_function	homoserine O-acetyltransferase activity
D	0009058	biological_process	biosynthetic process
D	0009086	biological_process	methionine biosynthetic process
D	0009092	biological_process	homoserine metabolic process
D	0016740	molecular_function	transferase activity
D	0016746	molecular_function	acyltransferase activity
D	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
D	0017000	biological_process	antibiotic biosynthetic process
D	0033813	molecular_function	deacetylcephalosporin-C acetyltransferase activity
E	0004414	molecular_function	homoserine O-acetyltransferase activity
E	0009058	biological_process	biosynthetic process
E	0009086	biological_process	methionine biosynthetic process
E	0009092	biological_process	homoserine metabolic process
E	0016740	molecular_function	transferase activity
E	0016746	molecular_function	acyltransferase activity
E	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
E	0017000	biological_process	antibiotic biosynthetic process
E	0033813	molecular_function	deacetylcephalosporin-C acetyltransferase activity
F	0004414	molecular_function	homoserine O-acetyltransferase activity
F	0009058	biological_process	biosynthetic process
F	0009086	biological_process	methionine biosynthetic process
F	0009092	biological_process	homoserine metabolic process
F	0016740	molecular_function	transferase activity
F	0016746	molecular_function	acyltransferase activity
F	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
F	0017000	biological_process	antibiotic biosynthetic process
F	0033813	molecular_function	deacetylcephalosporin-C acetyltransferase activity
G	0004414	molecular_function	homoserine O-acetyltransferase activity
G	0009058	biological_process	biosynthetic process
G	0009086	biological_process	methionine biosynthetic process
G	0009092	biological_process	homoserine metabolic process
G	0016740	molecular_function	transferase activity
G	0016746	molecular_function	acyltransferase activity
G	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
G	0017000	biological_process	antibiotic biosynthetic process
G	0033813	molecular_function	deacetylcephalosporin-C acetyltransferase activity
H	0004414	molecular_function	homoserine O-acetyltransferase activity
H	0009058	biological_process	biosynthetic process
H	0009086	biological_process	methionine biosynthetic process
H	0009092	biological_process	homoserine metabolic process
H	0016740	molecular_function	transferase activity
H	0016746	molecular_function	acyltransferase activity
H	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
H	0017000	biological_process	antibiotic biosynthetic process
H	0033813	molecular_function	deacetylcephalosporin-C acetyltransferase activity
I	0004414	molecular_function	homoserine O-acetyltransferase activity
I	0009058	biological_process	biosynthetic process
I	0009086	biological_process	methionine biosynthetic process
I	0009092	biological_process	homoserine metabolic process
I	0016740	molecular_function	transferase activity
I	0016746	molecular_function	acyltransferase activity
I	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
I	0017000	biological_process	antibiotic biosynthetic process
I	0033813	molecular_function	deacetylcephalosporin-C acetyltransferase activity
J	0004414	molecular_function	homoserine O-acetyltransferase activity
J	0009058	biological_process	biosynthetic process
J	0009086	biological_process	methionine biosynthetic process
J	0009092	biological_process	homoserine metabolic process
J	0016740	molecular_function	transferase activity
J	0016746	molecular_function	acyltransferase activity
J	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
J	0017000	biological_process	antibiotic biosynthetic process
J	0033813	molecular_function	deacetylcephalosporin-C acetyltransferase activity
K	0004414	molecular_function	homoserine O-acetyltransferase activity
K	0009058	biological_process	biosynthetic process
K	0009086	biological_process	methionine biosynthetic process
K	0009092	biological_process	homoserine metabolic process
K	0016740	molecular_function	transferase activity
K	0016746	molecular_function	acyltransferase activity
K	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
K	0017000	biological_process	antibiotic biosynthetic process
K	0033813	molecular_function	deacetylcephalosporin-C acetyltransferase activity
L	0004414	molecular_function	homoserine O-acetyltransferase activity
L	0009058	biological_process	biosynthetic process
L	0009086	biological_process	methionine biosynthetic process
L	0009092	biological_process	homoserine metabolic process
L	0016740	molecular_function	transferase activity
L	0016746	molecular_function	acyltransferase activity
L	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
L	0017000	biological_process	antibiotic biosynthetic process
L	0033813	molecular_function	deacetylcephalosporin-C acetyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE COA A1383

Chain	Residue
A	SER149
A	GLN281
A	LYS284
A	ASP363
A	MET367
A	HOH2096
A	HOH2163
A	HOH2164
A	HOH2165
A	ARG218
A	TYR225
A	LYS226
A	ARG234
A	ALA273
A	SER276
A	TYR277
A	TYR280

site_id	AC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE COA B1383

Chain	Residue
B	ARG218
B	TYR225
B	LYS226
B	ARG234
B	GLY268
B	ALA273
B	SER276
B	TYR277
B	TYR280
B	GLN281
B	LYS284
B	HIS362
B	ASP363
B	MET367
B	HOH2168
B	HOH2169
B	HOH2170
B	HOH2171

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE COA C1383

Chain	Residue
C	THR60
C	TYR225
C	LYS226
C	ARG234
C	ALA273
C	SER276
C	TYR277
C	TYR280
C	GLN281
C	LYS284
C	ASP363
C	PHE365
C	VAL366
C	MET367
C	HOH2136

site_id	AC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE COA D1383

Chain	Residue
D	THR60
D	ARG218
D	TYR225
D	LYS226
D	ARG234
D	ALA273
D	SER276
D	TYR277
D	TYR280
D	GLN281
D	LYS284
D	ASP363
D	MET367
D	HOH2123

site_id	AC5
Number of Residues	19
Details	BINDING SITE FOR RESIDUE COA E1383

Chain	Residue
E	SER149
E	ARG218
E	TYR225
E	LYS226
E	ARG234
E	GLY268
E	ALA273
E	SER276
E	TYR277
E	TYR280
E	GLN281
E	LYS284
E	HIS362
E	ASP363
E	MET367
E	HOH2161
E	HOH2162
E	HOH2163
E	HOH2164

site_id	AC6
Number of Residues	17
Details	BINDING SITE FOR RESIDUE COA F1383

Chain	Residue
F	HOH2102
F	THR58
F	THR60
F	ARG218
F	TYR225
F	LYS226
F	ARG234
F	GLY268
F	ALA273
F	SER276
F	TYR277
F	TYR280
F	GLN281
F	LYS284
F	ASP363
F	MET367
F	HOH2054

site_id	AC7
Number of Residues	14
Details	BINDING SITE FOR RESIDUE COA G1383

Chain	Residue
G	TYR225
G	ALA273
G	SER276
G	TYR277
G	TYR280
G	GLN281
G	LYS284
G	ASP363
G	PHE365
G	VAL366
G	MET367
G	HOH2140
J	ASP135
J	ARG136

site_id	AC8
Number of Residues	14
Details	BINDING SITE FOR RESIDUE COA H1383

Chain	Residue
H	SER149
H	TYR225
H	ALA273
H	SER276
H	TYR277
H	TYR280
H	GLN281
H	LYS284
H	HIS362
H	ASP363
H	PHE365
H	VAL366
H	MET367
H	HOH2144

site_id	AC9
Number of Residues	17
Details	BINDING SITE FOR RESIDUE COA I1383

Chain	Residue
I	THR58
I	ARG218
I	TYR225
I	LYS226
I	ARG234
I	GLY268
I	ALA273
I	SER276
I	TYR277
I	TYR280
I	GLN281
I	LYS284
I	HIS362
I	ASP363
I	MET367
I	HOH2162
I	HOH2163

site_id	BC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE COA J1385

Chain	Residue
J	THR58
J	LEU59
J	THR60
J	ARG218
J	LYS226
J	ARG234
J	GLY268
J	SER276
J	TYR277
J	TYR280
J	GLN281
J	LYS284
J	HIS362
J	ASP363
J	PHE365
J	VAL366
J	MET367

site_id	BC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE COA K1385

Chain	Residue
K	THR58
K	SER149
K	ARG218
K	TYR225
K	LYS226
K	ARG234
K	GLY268
K	ALA273
K	SER276
K	TYR277
K	TYR280
K	GLN281
K	LYS284
K	HIS362
K	ASP363
K	PHE365
K	MET367

site_id	BC3
Number of Residues	16
Details	BINDING SITE FOR RESIDUE COA L1383

Chain	Residue
L	THR58
L	THR60
L	ARG218
L	TYR225
L	LYS226
L	ARG234
L	GLY268
L	ALA273
L	SER276
L	TYR277
L	TYR280
L	GLN281
L	LYS284
L	ASP363
L	MET367
L	HOH2104

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL B1384

Chain	Residue
B	TRP185
B	THR224
B	GLY334

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL I1384

Chain	Residue
A	HOH2101
I	TRP185
I	THR224
I	GLY334

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT A1384

Chain	Residue
A	ARG124
A	GLU157
A	PHE161
A	ARG310
B	THR25
B	ILE31

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT B1385

Chain	Residue
A	THR25
A	ILE31
B	GLU157
B	PHE161
B	ARG310

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT E1384

Chain	Residue
E	ARG124
E	ARG128
E	GLU157
E	PHE161
I	THR25
I	ILE31

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT I1385

Chain	Residue
E	THR25
E	ILE31
I	ARG124
I	GLU157
I	PHE160
I	PHE161

site_id	CC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACT H1384

Chain	Residue
H	ARG128
H	GLU157

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT G1384

Chain	Residue
G	ARG124
G	ARG128
G	GLU157

site_id	CC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT D1384

Chain	Residue
D	ARG128
D	GLU157
D	PHE161

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT C1384

Chain	Residue
A	VAL47
C	ARG128
C	GLU157
C	PHE161

site_id	CC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACT F1384

Chain	Residue
F	ARG128
F	GLU157

site_id	CC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT J1386

Chain	Residue
J	VAL127
J	GLU157
J	PHE161

site_id	CC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT K1386

Chain	Residue
K	VAL127
K	ARG128
K	GLU157

site_id	CC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACT L1384

Chain	Residue
L	ARG128
L	GLU157

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1azw

Chain	Residue	Details
A	HIS362
A	SER149
A	ASP333

site_id	CSA10
Number of Residues	3
Details	Annotated By Reference To The Literature 1azw

Chain	Residue	Details
J	HIS362
J	SER149
J	ASP333

site_id	CSA11
Number of Residues	3
Details	Annotated By Reference To The Literature 1azw

Chain	Residue	Details
K	HIS362
K	SER149
K	ASP333

site_id	CSA12
Number of Residues	3
Details	Annotated By Reference To The Literature 1azw

Chain	Residue	Details
L	HIS362
L	SER149
L	ASP333

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1azw

Chain	Residue	Details
B	HIS362
B	SER149
B	ASP333

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1azw

Chain	Residue	Details
C	HIS362
C	SER149
C	ASP333

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1azw

Chain	Residue	Details
D	HIS362
D	SER149
D	ASP333

site_id	CSA5
Number of Residues	3
Details	Annotated By Reference To The Literature 1azw

Chain	Residue	Details
E	HIS362
E	SER149
E	ASP333

site_id	CSA6
Number of Residues	3
Details	Annotated By Reference To The Literature 1azw

Chain	Residue	Details
F	HIS362
F	SER149
F	ASP333

site_id	CSA7
Number of Residues	3
Details	Annotated By Reference To The Literature 1azw

Chain	Residue	Details
G	HIS362
G	SER149
G	ASP333

site_id	CSA8
Number of Residues	3
Details	Annotated By Reference To The Literature 1azw

Chain	Residue	Details
H	HIS362
H	SER149
H	ASP333

site_id	CSA9
Number of Residues	3
Details	Annotated By Reference To The Literature 1azw

Chain	Residue	Details
I	HIS362
I	SER149
I	ASP333

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)