2V9K
Crystal structure of human PUS10, a novel pseudouridine synthase.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001522 | biological_process | pseudouridine synthesis |
| A | 0003723 | molecular_function | RNA binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0009451 | biological_process | RNA modification |
| A | 0009982 | molecular_function | pseudouridine synthase activity |
| A | 0031053 | biological_process | primary miRNA processing |
| A | 0031119 | biological_process | tRNA pseudouridine synthesis |
| A | 0070878 | molecular_function | primary miRNA binding |
| A | 0106029 | molecular_function | tRNA pseudouridine synthase activity |
| A | 0160148 | molecular_function | tRNA pseudouridine(55) synthase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A1529 |
| Chain | Residue |
| A | ARG447 |
| A | ILE486 |
| A | LYS487 |
| A | EPE1534 |
| A | HOH2206 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A1530 |
| Chain | Residue |
| A | GLY341 |
| A | ARG354 |
| A | HOH2265 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A1531 |
| Chain | Residue |
| A | HOH2091 |
| A | ASN385 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A1532 |
| Chain | Residue |
| A | VAL146 |
| A | LYS183 |
| A | LYS187 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A1533 |
| Chain | Residue |
| A | CYS21 |
| A | CYS24 |
| A | CYS109 |
| A | CYS112 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE EPE A1534 |
| Chain | Residue |
| A | ARG342 |
| A | GLU343 |
| A | ASP344 |
| A | ARG452 |
| A | ARG457 |
| A | GLY483 |
| A | THR484 |
| A | TYR485 |
| A | CL1529 |
| A | HOH2206 |
| A | HOH2316 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EPE A1535 |
| Chain | Residue |
| A | ASN254 |
| A | TRP419 |
| A | HIS473 |
| A | LEU512 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A1536 |
| Chain | Residue |
| A | THR18 |
| A | ASN110 |
| A | PRO268 |
| A | PRO269 |
| A | ASN270 |
| A | HOH2140 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 13 |
| Details | Region: {"description":"RNA binding forefinger loop","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 15 |
| Details | Region: {"description":"RNA binding thumb loop","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"30530625","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31819270","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17900615","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2V9K","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
