2V8C

Mouse Profilin IIa in complex with the proline-rich domain of VASP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003779	molecular_function	actin binding
A	0003785	molecular_function	actin monomer binding
A	0005515	molecular_function	protein binding
A	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0010633	biological_process	negative regulation of epithelial cell migration
A	0016887	molecular_function	ATP hydrolysis activity
A	0030036	biological_process	actin cytoskeleton organization
A	0030833	biological_process	regulation of actin filament polymerization
A	0030837	biological_process	negative regulation of actin filament polymerization
A	0030838	biological_process	positive regulation of actin filament polymerization
A	0032233	biological_process	positive regulation of actin filament bundle assembly
A	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
A	0044087	biological_process	regulation of cellular component biogenesis
A	0050804	biological_process	modulation of chemical synaptic transmission
A	0050821	biological_process	protein stabilization
A	0051496	biological_process	positive regulation of stress fiber assembly
A	0098685	cellular_component	Schaffer collateral - CA1 synapse
A	0098793	cellular_component	presynapse
A	0098794	cellular_component	postsynapse
A	0098885	biological_process	modification of postsynaptic actin cytoskeleton
A	0098978	cellular_component	glutamatergic synapse
A	0099140	biological_process	presynaptic actin cytoskeleton organization
A	0099171	biological_process	presynaptic modulation of chemical synaptic transmission
A	0110053	biological_process	regulation of actin filament organization
A	1900028	biological_process	negative regulation of ruffle assembly
A	2000300	biological_process	regulation of synaptic vesicle exocytosis

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1001

Chain	Residue
A	ARG104
A	GLY106
A	ARG135

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 1002

Chain	Residue
A	ARG88
A	LYS132
A	ARG135
A	ASP136
A	HOH610
A	IPA2001

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1003

Chain	Residue
A	ARG74
A	GLN92
A	GLY93
A	HOH611

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site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE IPA A 2001

Chain	Residue
A	ASP82
A	CYS83
A	ARG104
A	TYR128
A	LYS132
A	ARG135
A	SO41002

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site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IPA A 2002

Chain	Residue
A	LYS28
A	GLU95

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site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE NA A 3001

Chain	Residue
A	ALA35

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site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 4001

Chain	Residue
A	THR97
A	ASN99
A	GLU116
A	GLY117

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Functional Information from PROSITE/UniProt

site_id	PS00414
Number of Residues	9
Details	PROFILIN Profilin signature. mAgWQsYvD

Chain	Residue	Details
A	MET0-ASP8

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:P35080

Chain	Residue	Details
A	ALA1

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