2V8C
Mouse Profilin IIa in complex with the proline-rich domain of VASP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003779 | molecular_function | actin binding |
| A | 0003785 | molecular_function | actin monomer binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005546 | molecular_function | phosphatidylinositol-4,5-bisphosphate binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0010633 | biological_process | negative regulation of epithelial cell migration |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0030036 | biological_process | actin cytoskeleton organization |
| A | 0030833 | biological_process | regulation of actin filament polymerization |
| A | 0030838 | biological_process | positive regulation of actin filament polymerization |
| A | 0032233 | biological_process | positive regulation of actin filament bundle assembly |
| A | 0050804 | biological_process | modulation of chemical synaptic transmission |
| A | 0050821 | biological_process | protein stabilization |
| A | 0051496 | biological_process | positive regulation of stress fiber assembly |
| A | 0098685 | cellular_component | Schaffer collateral - CA1 synapse |
| A | 0098793 | cellular_component | presynapse |
| A | 0098794 | cellular_component | postsynapse |
| A | 0098885 | biological_process | modification of postsynaptic actin cytoskeleton |
| A | 0098978 | cellular_component | glutamatergic synapse |
| A | 0099140 | biological_process | presynaptic actin cytoskeleton organization |
| A | 0099171 | biological_process | presynaptic modulation of chemical synaptic transmission |
| A | 1900028 | biological_process | negative regulation of ruffle assembly |
| A | 2000300 | biological_process | regulation of synaptic vesicle exocytosis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1001 |
| Chain | Residue |
| A | ARG104 |
| A | GLY106 |
| A | ARG135 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1002 |
| Chain | Residue |
| A | ARG88 |
| A | LYS132 |
| A | ARG135 |
| A | ASP136 |
| A | HOH610 |
| A | IPA2001 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1003 |
| Chain | Residue |
| A | ARG74 |
| A | GLN92 |
| A | GLY93 |
| A | HOH611 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE IPA A 2001 |
| Chain | Residue |
| A | ASP82 |
| A | CYS83 |
| A | ARG104 |
| A | TYR128 |
| A | LYS132 |
| A | ARG135 |
| A | SO41002 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IPA A 2002 |
| Chain | Residue |
| A | LYS28 |
| A | GLU95 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE NA A 3001 |
| Chain | Residue |
| A | ALA35 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 4001 |
| Chain | Residue |
| A | THR97 |
| A | ASN99 |
| A | GLU116 |
| A | GLY117 |
Functional Information from PROSITE/UniProt
| site_id | PS00414 |
| Number of Residues | 9 |
| Details | PROFILIN Profilin signature. mAgWQsYvD |
| Chain | Residue | Details |
| A | MET0-ASP8 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"UniProtKB","id":"P35080","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
