2V86

Crystal structure of RAG2-PHD finger in complex with H3R2me2aK4me3 peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0005634	cellular_component	nucleus
A	0006310	biological_process	DNA recombination
B	0003677	molecular_function	DNA binding
B	0005634	cellular_component	nucleus
B	0006310	biological_process	DNA recombination

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1488

Chain	Residue
A	CYS419
A	CYS423
A	HIS455
A	CYS458

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1489

Chain	Residue
A	CYS446
A	HIS452
A	CYS478
A	HIS481

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1488

Chain	Residue
B	CYS423
B	HIS455
B	CYS458
B	CYS419

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1489

Chain	Residue
B	CYS446
B	HIS452
B	CYS478
B	HIS481

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Citrulline; alternate => ECO:0000269|PubMed:15339660

Chain	Residue	Details
D	DA22
E	DA22

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by HASPIN and VRK1 => ECO:0000250|UniProtKB:Q71DI3, ECO:0000269|PubMed:15681610

Chain	Residue	Details
D	THR3
E	THR3
B	CYS419
B	CYS423
B	CYS446
B	HIS452
B	HIS455
B	CYS458
B	CYS478
B	HIS481
A	CYS446
A	HIS452
A	HIS455
A	CYS458
A	CYS478
A	HIS481

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:17194708

Chain	Residue	Details
D	M3L4
E	M3L4

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: 5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594

Chain	Residue	Details
D	GLN5
E	GLN5

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by PKC => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
D	THR6
E	THR6

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000269|PubMed:15485929

Chain	Residue	Details
D	ARG8
E	ARG8

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:13678296, ECO:0000269|PubMed:17194708

Chain	Residue	Details
D	ALA9
E	ALA9

---