2V7E

Crystal structure of coactivator-associated arginine methyltransferase 1 (CARM1), unliganded

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016274	molecular_function	protein-arginine N-methyltransferase activity
A	0018216	biological_process	peptidyl-arginine methylation
B	0016274	molecular_function	protein-arginine N-methyltransferase activity
B	0018216	biological_process	peptidyl-arginine methylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE HG B1477

Chain	Residue
B	ASP191
B	CYS194

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE HG A1477

Chain	Residue
A	CYS421
A	ILE453
A	LEU468

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE HG A1478

Chain	Residue
A	CYS421
A	LEU422
A	ASN466

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	66
Details	Region: {"description":"Required for nuclear translocation","evidences":[{"source":"PubMed","id":"30366907","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17882261","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19843527","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"Q86X55","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1or8

Chain	Residue	Details
A	GLU258
A	GLU267

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site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1or8

Chain	Residue	Details
B	GLU258
B	GLU267

---