2V6J

Kokobera Virus Helicase: Mutant Met47Thr

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Functional Information from GO Data

ChainGOidnamespacecontents
A0005576cellular_componentextracellular region
A0044167cellular_componenthost cell endoplasmic reticulum membrane
A0042025cellular_componenthost cell nucleus
A0044220cellular_componenthost cell perinuclear region of cytoplasm
A0016021cellular_componentintegral component of membrane
A0019028cellular_componentviral capsid
A0019031cellular_componentviral envelope
A0055036cellular_componentvirion membrane
A0005524molecular_functionATP binding
A0003725molecular_functiondouble-stranded RNA binding
A0046872molecular_functionmetal ion binding
A0004482molecular_functionmRNA (guanine-N7-)-methyltransferase activity
A0004483molecular_functionmRNA (nucleoside-2'-O-)-methyltransferase activity
A0046983molecular_functionprotein dimerization activity
A0003724molecular_functionRNA helicase activity
A0003968molecular_functionRNA-directed 5'-3' RNA polymerase activity
A0004252molecular_functionserine-type endopeptidase activity
A0005198molecular_functionstructural molecule activity
A0039654biological_processfusion of virus membrane with host endosome membrane
A0039520biological_processinduction by virus of host autophagy
A0039563biological_processsuppression by virus of host STAT1 activity
A0039564biological_processsuppression by virus of host STAT2 activity
A0039502biological_processsuppression by virus of host type I interferon-mediated signaling pathway
A0039694biological_processviral RNA genome replication
A0019062biological_processvirion attachment to host cell
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
SWS_FT_FI13Charge relay system; for serine protease NS3 activity. {ECO:0000255|PROSITE- ProRule:PRU00860}.
ChainResidueDetails
ANA*
ANA*
ANA*

SWS_FT_FI24For 2'-O-MTase activity. {ECO:0000250|UniProtKB:Q6YMS4}.
ChainResidueDetails
ANA*
ANA*
ANA*
ANA*

SWS_FT_FI33Zinc 1. {ECO:0000250|UniProtKB:P14335}
ChainResidueDetails
ANA*
ANA*
ANA*

SWS_FT_FI42Zinc 2. {ECO:0000250|UniProtKB:P14335}
ChainResidueDetails
ANA*
ANA*

SWS_FT_FI51Zinc 1; via tele nitrogen. {ECO:0000250|UniProtKB:P14335}
ChainResidueDetails
ANA*

SWS_FT_FI61Zinc 2; via tele nitrogen. {ECO:0000250|UniProtKB:P14335}
ChainResidueDetails
ANA*

SWS_FT_FI74S-adenosyl-L-methionine. {ECO:0000255|PROSITE-ProRule:PRU00924}.
ChainResidueDetails
ANA*
ANA*
ANA*
ANA*

SWS_FT_FI85mRNA cap. {ECO:0000255|PROSITE- ProRule:PRU00924}.
ChainResidueDetails
ANA*
ANA*
ANA*
ANA*
ANA*

SWS_FT_FI92mRNA cap; via carbonyl oxygen. {ECO:0000255|PROSITE-ProRule:PRU00924}.
ChainResidueDetails
ANA*
ANA*

SWS_FT_FI104S-adenosyl-L-methionine; via carbonyl oxygen. {ECO:0000255|PROSITE- ProRule:PRU00924}.
ChainResidueDetails
ANA*
ANA*
ANA*
ANA*

SWS_FT_FI112Essential for 2'-O-methyltransferase activity. {ECO:0000250|UniProtKB:P06935}.
ChainResidueDetails
ANA*
ANA*

SWS_FT_FI122Cleavage; by host. {ECO:0000250|UniProtKB:P06935}.
ChainResidueDetails
ANA*

SWS_FT_FI132Involved in NS3 ATPase and RTPase activities. {ECO:0000250|UniProtKB:P14335}.
ChainResidueDetails
AARG270
AARG273

SWS_FT_FI141Essential for 2'-O-methyltransferase and N-7 methyltransferase activity. {ECO:0000250|UniProtKB:P06935}.
ChainResidueDetails
ANA*

SWS_FT_FI158Cleavage; by viral protease NS3. {ECO:0000250|UniProtKB:P06935}.
ChainResidueDetails
ANA*
ANA*
ANA*
ANA*

SWS_FT_FI162Cleavage; by host furin. {ECO:0000250|UniProtKB:P06935}.
ChainResidueDetails
ANA*

SWS_FT_FI173Substrate binding. {ECO:0000269|PubMed:18004778}.
ChainResidueDetails
ALYS15
AARG273
AARG276

SWS_FT_FI184Cleavage; by autolysis. {ECO:0000250|UniProtKB:P06935}.
ChainResidueDetails
ANA*
AARG431

SWS_FT_FI196Cleavage; by host signal peptidase. {ECO:0000250|UniProtKB:P06935}.
ChainResidueDetails
ANA*
ANA*
ANA*

SWS_FT_FI201S-adenosyl-L-methionine binding. {ECO:0000255|PROSITE-ProRule:PRU00924}.
ChainResidueDetails
ANA*

SWS_FT_FI212Cleavage; by host signal peptidase. {ECO:0000255}.
ChainResidueDetails
ANA*

SWS_FT_FI221mRNA cap binding. {ECO:0000255|PROSITE- ProRule:PRU00924}.
ChainResidueDetails
ANA*

SWS_FT_FI238ATP. {ECO:0000255|PROSITE- ProRule:PRU00541}.
ChainResidueDetails
ALEU9-THR16

SWS_FT_FI2415Helical; Note=Signal for NS4B. {ECO:0000305}.
ChainResidueDetails
ANA*

SWS_FT_FI25336Helical. {ECO:0000255}.
ChainResidueDetails
ANA*
ANA*
ANA*
ANA*
ANA*
ANA*
ANA*
ANA*
ANA*
ANA*
ANA*
ANA*
ANA*
ANA*
ANA*
ANA*

SWS_FT_FI2615Helical. {ECO:0000305}.
ChainResidueDetails
ANA*

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Catalytic Information from CSA

site_idNumber of ResiduesDetails