2V57
Crystal structure of the TetR-like transcriptional regulator LfrR from Mycobacterium smegmatis in complex with proflavine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000976 | molecular_function | transcription cis-regulatory region binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0000976 | molecular_function | transcription cis-regulatory region binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0006351 | biological_process | DNA-templated transcription |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0000976 | molecular_function | transcription cis-regulatory region binding |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003700 | molecular_function | DNA-binding transcription factor activity |
| C | 0006351 | biological_process | DNA-templated transcription |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0000976 | molecular_function | transcription cis-regulatory region binding |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003700 | molecular_function | DNA-binding transcription factor activity |
| D | 0006351 | biological_process | DNA-templated transcription |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PRL C 1187 |
| Chain | Residue |
| C | HIS67 |
| C | IPA1189 |
| C | SER70 |
| C | ASN71 |
| C | ILE74 |
| C | TYR106 |
| C | PHE121 |
| C | ASP125 |
| C | ARG148 |
| C | TRP152 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PRL A 1188 |
| Chain | Residue |
| A | HIS67 |
| A | SER70 |
| A | ASN71 |
| A | ILE74 |
| A | TYR106 |
| A | PHE121 |
| A | ASP125 |
| A | ARG148 |
| A | TRP152 |
| A | IPA1189 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1187 |
| Chain | Residue |
| A | PRO167 |
| A | ARG168 |
| D | ARG15 |
| D | TYR52 |
| D | ALA61 |
| D | ARG64 |
| D | HOH2024 |
| D | HOH2087 |
| D | HOH2088 |
| D | HOH2089 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1187 |
| Chain | Residue |
| B | ARG15 |
| B | TYR52 |
| B | ALA61 |
| B | ARG64 |
| B | HOH2031 |
| B | HOH2086 |
| C | PRO167 |
| C | ARG168 |
| C | HOH2089 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1188 |
| Chain | Residue |
| B | ARG60 |
| B | ARG64 |
| B | ASP114 |
| B | GLU116 |
| B | HOH2029 |
| C | ARG168 |
| C | HOH2099 |
| C | HOH2100 |
| C | HOH2101 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1188 |
| Chain | Residue |
| A | ARG168 |
| D | ARG60 |
| D | ARG64 |
| D | ASP114 |
| D | GLU116 |
| D | HOH2022 |
| D | HOH2090 |
| D | HOH2091 |
| D | HOH2092 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1188 |
| Chain | Residue |
| B | ARG168 |
| B | HIS169 |
| C | ARG64 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1189 |
| Chain | Residue |
| D | ARG168 |
| D | HIS169 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IPA A 1189 |
| Chain | Residue |
| A | TRP152 |
| A | PRL1188 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IPA C 1189 |
| Chain | Residue |
| C | TRP152 |
| C | PRL1187 |
