2V54
Crystal structure of vaccinia virus thymidylate kinase bound to TDP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
| A | 0004798 | molecular_function | thymidylate kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006227 | biological_process | dUDP biosynthetic process |
| A | 0006233 | biological_process | dTDP biosynthetic process |
| A | 0006235 | biological_process | dTTP biosynthetic process |
| A | 0009165 | biological_process | nucleotide biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
| B | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
| B | 0004798 | molecular_function | thymidylate kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006227 | biological_process | dUDP biosynthetic process |
| B | 0006233 | biological_process | dTDP biosynthetic process |
| B | 0006235 | biological_process | dTTP biosynthetic process |
| B | 0009165 | biological_process | nucleotide biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 1205 |
| Chain | Residue |
| B | ASP13 |
| B | GLU145 |
| B | POP1206 |
| B | TYD1207 |
| B | HOH2046 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE TYD A 1205 |
| Chain | Residue |
| A | PHE38 |
| A | PRO39 |
| A | ARG41 |
| A | LEU53 |
| A | PHE68 |
| A | ARG72 |
| A | ASP92 |
| A | ARG93 |
| A | GLY98 |
| A | TYR101 |
| A | TYR144 |
| A | HOH2009 |
| A | HOH2024 |
| A | HOH2046 |
| A | ASP13 |
| A | LYS17 |
| A | THR18 |
| A | ASN37 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE POP B 1206 |
| Chain | Residue |
| B | LYS14 |
| B | SER15 |
| B | GLY16 |
| B | LYS17 |
| B | THR18 |
| B | GLU145 |
| B | MG1205 |
| B | TYD1207 |
| B | HOH2005 |
| site_id | AC4 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE TYD B 1207 |
| Chain | Residue |
| B | ASP13 |
| B | LYS17 |
| B | PHE38 |
| B | PRO39 |
| B | ARG41 |
| B | LEU53 |
| B | PHE68 |
| B | ARG72 |
| B | ARG93 |
| B | SER97 |
| B | GLY98 |
| B | TYR101 |
| B | TYR144 |
| B | MG1205 |
| B | POP1206 |
| B | HOH2009 |
| B | HOH2028 |
| B | HOH2046 |
Functional Information from PROSITE/UniProt
| site_id | PS01331 |
| Number of Residues | 13 |
| Details | THYMIDYLATE_KINASE Thymidylate kinase signature. IVDRYafSGvAYA |
| Chain | Residue | Details |
| A | ILE90-ALA102 |
