2V4Y
THE STRUCTURE OF E. COLI UMP KINASE IN COMPLEX WITH ITS ALLOSTERIC REGULATOR GTP
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005524 | molecular_function | ATP binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
A | 0006225 | biological_process | UDP biosynthetic process |
A | 0009041 | molecular_function | UMP/dUMP kinase activity |
A | 0016301 | molecular_function | kinase activity |
A | 0016310 | biological_process | phosphorylation |
A | 0033862 | molecular_function | UMP kinase activity |
A | 0042802 | molecular_function | identical protein binding |
A | 0044210 | biological_process | 'de novo' CTP biosynthetic process |
A | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
B | 0005524 | molecular_function | ATP binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
B | 0006225 | biological_process | UDP biosynthetic process |
B | 0009041 | molecular_function | UMP/dUMP kinase activity |
B | 0016301 | molecular_function | kinase activity |
B | 0016310 | biological_process | phosphorylation |
B | 0033862 | molecular_function | UMP kinase activity |
B | 0042802 | molecular_function | identical protein binding |
B | 0044210 | biological_process | 'de novo' CTP biosynthetic process |
B | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
C | 0005524 | molecular_function | ATP binding |
C | 0005737 | cellular_component | cytoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
C | 0006225 | biological_process | UDP biosynthetic process |
C | 0009041 | molecular_function | UMP/dUMP kinase activity |
C | 0016301 | molecular_function | kinase activity |
C | 0016310 | biological_process | phosphorylation |
C | 0033862 | molecular_function | UMP kinase activity |
C | 0042802 | molecular_function | identical protein binding |
C | 0044210 | biological_process | 'de novo' CTP biosynthetic process |
C | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
D | 0005524 | molecular_function | ATP binding |
D | 0005737 | cellular_component | cytoplasm |
D | 0005829 | cellular_component | cytosol |
D | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
D | 0006225 | biological_process | UDP biosynthetic process |
D | 0009041 | molecular_function | UMP/dUMP kinase activity |
D | 0016301 | molecular_function | kinase activity |
D | 0016310 | biological_process | phosphorylation |
D | 0033862 | molecular_function | UMP kinase activity |
D | 0042802 | molecular_function | identical protein binding |
D | 0044210 | biological_process | 'de novo' CTP biosynthetic process |
D | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
E | 0005524 | molecular_function | ATP binding |
E | 0005737 | cellular_component | cytoplasm |
E | 0005829 | cellular_component | cytosol |
E | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
E | 0006225 | biological_process | UDP biosynthetic process |
E | 0009041 | molecular_function | UMP/dUMP kinase activity |
E | 0016301 | molecular_function | kinase activity |
E | 0016310 | biological_process | phosphorylation |
E | 0033862 | molecular_function | UMP kinase activity |
E | 0042802 | molecular_function | identical protein binding |
E | 0044210 | biological_process | 'de novo' CTP biosynthetic process |
E | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
F | 0005524 | molecular_function | ATP binding |
F | 0005737 | cellular_component | cytoplasm |
F | 0005829 | cellular_component | cytosol |
F | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
F | 0006225 | biological_process | UDP biosynthetic process |
F | 0009041 | molecular_function | UMP/dUMP kinase activity |
F | 0016301 | molecular_function | kinase activity |
F | 0016310 | biological_process | phosphorylation |
F | 0033862 | molecular_function | UMP kinase activity |
F | 0042802 | molecular_function | identical protein binding |
F | 0044210 | biological_process | 'de novo' CTP biosynthetic process |
F | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE GTP A 1242 |
Chain | Residue |
A | ARG92 |
E | SER124 |
E | ARG127 |
F | ASN72 |
F | VAL75 |
A | ASP93 |
A | HIS96 |
A | ASN101 |
A | ALA102 |
A | ARG103 |
A | ARG130 |
E | TRP119 |
E | ALA120 |
site_id | AC2 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE GTP B 1242 |
Chain | Residue |
A | TRP119 |
A | ALA120 |
A | SER124 |
A | ARG127 |
B | ARG92 |
B | ASP93 |
B | HIS96 |
B | ASN101 |
B | ALA102 |
B | ARG103 |
B | ARG130 |
D | ASN72 |
D | VAL75 |
site_id | AC3 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE GTP C 1242 |
Chain | Residue |
B | LYS6 |
C | ARG92 |
C | ASP93 |
C | HIS96 |
C | ASN101 |
C | ALA102 |
C | ARG103 |
C | ARG130 |
E | ASN72 |
E | VAL75 |
F | TRP119 |
F | ALA120 |
F | SER124 |
F | ARG127 |
site_id | AC4 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE GTP D 1242 |
Chain | Residue |
B | ASN72 |
B | VAL75 |
C | TRP119 |
C | ALA120 |
C | SER124 |
C | ARG127 |
D | ARG92 |
D | ASP93 |
D | HIS96 |
D | ASN101 |
D | ALA102 |
D | ARG103 |
D | ARG130 |
site_id | AC5 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE GTP E 1242 |
Chain | Residue |
B | TRP119 |
B | ALA120 |
B | SER124 |
B | ARG127 |
C | ASN72 |
C | VAL75 |
E | ARG92 |
E | ASP93 |
E | HIS96 |
E | ASN101 |
E | ALA102 |
E | ARG103 |
E | ARG130 |
F | LYS6 |
site_id | AC6 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE GTP F 1242 |
Chain | Residue |
A | ASN72 |
D | TRP119 |
D | ALA120 |
D | SER124 |
D | ARG127 |
F | ARG92 |
F | ASP93 |
F | HIS96 |
F | ASN101 |
F | ALA102 |
F | ARG103 |
F | ARG130 |
site_id | AC7 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GTP F 1243 |
Chain | Residue |
F | SER17 |
F | GLY18 |
F | GLU19 |
F | GLY56 |
F | GLY57 |
F | GLY58 |
F | THR144 |
F | THR145 |
site_id | AC8 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GTP A 1243 |
Chain | Residue |
A | SER17 |
A | GLY18 |
A | GLU19 |
A | GLY56 |
A | GLY57 |
A | GLY58 |
A | THR144 |
A | THR145 |
site_id | AC9 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE GTP B 1243 |
Chain | Residue |
B | GLY57 |
B | GLY58 |
B | THR144 |
B | THR145 |
B | HOH2003 |
B | SER17 |
B | GLY18 |
B | GLU19 |
B | GLY56 |
site_id | BC1 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE GTP D 1243 |
Chain | Residue |
D | SER17 |
D | GLY18 |
D | GLU19 |
D | GLY56 |
D | GLY57 |
D | GLY58 |
D | THR144 |
D | THR145 |
D | HOH2003 |
site_id | BC2 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GTP C 1243 |
Chain | Residue |
C | SER17 |
C | GLY18 |
C | GLU19 |
C | GLY56 |
C | GLY57 |
C | GLY58 |
C | THR144 |
C | THR145 |
site_id | BC3 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE GTP E 1243 |
Chain | Residue |
E | SER17 |
E | GLY18 |
E | GLU19 |
E | GLY56 |
E | GLY57 |
E | GLY58 |
E | THR144 |
E | THR145 |
E | HOH2002 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 18 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15857829, ECO:0000269|PubMed:18945668, ECO:0007744|PDB:2BND, ECO:0007744|PDB:2BNF, ECO:0007744|PDB:2V4Y |
Chain | Residue | Details |
A | LYS15 | |
D | LYS15 | |
D | GLY57 | |
D | GLY58 | |
E | LYS15 | |
E | GLY57 | |
E | GLY58 | |
F | LYS15 | |
F | GLY57 | |
F | GLY58 | |
A | GLY57 | |
A | GLY58 | |
B | LYS15 | |
B | GLY57 | |
B | GLY58 | |
C | LYS15 | |
C | GLY57 | |
C | GLY58 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15857829, ECO:0007744|PDB:2BND, ECO:0007744|PDB:2BNE, ECO:0007744|PDB:2BNF |
Chain | Residue | Details |
A | ARG62 | |
B | ARG62 | |
C | ARG62 | |
D | ARG62 | |
E | ARG62 | |
F | ARG62 |
site_id | SWS_FT_FI3 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15857829, ECO:0000269|PubMed:18945668, ECO:0007744|PDB:2BNE, ECO:0007744|PDB:2BNF, ECO:0007744|PDB:2V4Y |
Chain | Residue | Details |
A | ASP77 | |
B | ASP77 | |
C | ASP77 | |
D | ASP77 | |
E | ASP77 | |
F | ASP77 |
site_id | SWS_FT_FI4 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:18945668, ECO:0007744|PDB:2V4Y |
Chain | Residue | Details |
A | ARG92 | |
E | ASN101 | |
F | ARG92 | |
F | ASN101 | |
A | ASN101 | |
B | ARG92 | |
B | ASN101 | |
C | ARG92 | |
C | ASN101 | |
D | ARG92 | |
D | ASN101 | |
E | ARG92 |
site_id | SWS_FT_FI5 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15857829, ECO:0000269|PubMed:18945668, ECO:0007744|PDB:2BND, ECO:0007744|PDB:2BNE, ECO:0007744|PDB:2BNF, ECO:0007744|PDB:2V4Y |
Chain | Residue | Details |
A | THR138 | |
B | THR138 | |
C | THR138 | |
D | THR138 | |
E | THR138 | |
F | THR138 |
site_id | SWS_FT_FI6 |
Number of Residues | 18 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | THR165 | |
D | THR165 | |
D | PHE171 | |
D | ASP174 | |
E | THR165 | |
E | PHE171 | |
E | ASP174 | |
F | THR165 | |
F | PHE171 | |
F | ASP174 | |
A | PHE171 | |
A | ASP174 | |
B | THR165 | |
B | PHE171 | |
B | ASP174 | |
C | THR165 | |
C | PHE171 | |
C | ASP174 |