2V4M
The isomerase domain of human glutamine-fructose-6-phosphate transaminase 1 (GFPT1) in complex with fructose 6-phosphate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0097367 | molecular_function | carbohydrate derivative binding |
| A | 1901135 | biological_process | carbohydrate derivative metabolic process |
| B | 0097367 | molecular_function | carbohydrate derivative binding |
| B | 1901135 | biological_process | carbohydrate derivative metabolic process |
| C | 0097367 | molecular_function | carbohydrate derivative binding |
| C | 1901135 | biological_process | carbohydrate derivative metabolic process |
| D | 0097367 | molecular_function | carbohydrate derivative binding |
| D | 1901135 | biological_process | carbohydrate derivative metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE F6R A 800 |
| Chain | Residue |
| A | CYS392 |
| A | SER492 |
| A | LYS576 |
| A | GLU579 |
| A | HOH2035 |
| B | HIS595 |
| A | GLY393 |
| A | THR394 |
| A | SER395 |
| A | SER439 |
| A | GLN440 |
| A | SER441 |
| A | THR444 |
| A | ALA491 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE F6R B 800 |
| Chain | Residue |
| A | HIS595 |
| B | CYS392 |
| B | GLY393 |
| B | THR394 |
| B | SER395 |
| B | SER439 |
| B | GLN440 |
| B | SER441 |
| B | THR444 |
| B | ALA491 |
| B | SER492 |
| B | LYS576 |
| B | GLU579 |
| B | HOH2011 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE F6R C 800 |
| Chain | Residue |
| C | GLY393 |
| C | THR394 |
| C | SER395 |
| C | SER439 |
| C | GLN440 |
| C | SER441 |
| C | THR444 |
| C | ALA491 |
| C | SER492 |
| C | LYS576 |
| C | GLU579 |
| C | HOH2023 |
| C | HOH2050 |
| D | HIS595 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE F6R D 800 |
| Chain | Residue |
| C | HIS595 |
| D | GLY393 |
| D | THR394 |
| D | SER395 |
| D | SER439 |
| D | GLN440 |
| D | SER441 |
| D | THR444 |
| D | ALA491 |
| D | SER492 |
| D | LYS576 |
| D | GLU579 |
| D | HOH2025 |
| D | HOH2065 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL C1691 |
| Chain | Residue |
| C | ARG361 |
| C | LEU371 |
| C | GLY372 |
| C | GLY373 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 556 |
| Details | Domain: {"description":"SIS 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00797","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19059404","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2V4M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZJ4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 141 |
| Details | Domain: {"description":"SIS 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00797","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1jxa |
| Chain | Residue | Details |
| A | GLU579 | |
| A | LYS576 | |
| A | GLU572 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1jxa |
| Chain | Residue | Details |
| B | GLU579 | |
| B | LYS576 | |
| B | GLU572 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1jxa |
| Chain | Residue | Details |
| C | GLU579 | |
| C | LYS576 | |
| C | GLU572 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1jxa |
| Chain | Residue | Details |
| D | GLU579 | |
| D | LYS576 | |
| D | GLU572 |
| site_id | CSA5 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1jxa |
| Chain | Residue | Details |
| A | HIS595 |
| site_id | CSA6 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1jxa |
| Chain | Residue | Details |
| B | HIS595 |
| site_id | CSA7 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1jxa |
| Chain | Residue | Details |
| C | HIS595 |
| site_id | CSA8 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1jxa |
| Chain | Residue | Details |
| D | HIS595 |
