2V2Z
IspE in complex with ADP and CDPME
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0016114 | biological_process | terpenoid biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
| A | 0050515 | molecular_function | 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0016114 | biological_process | terpenoid biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
| B | 0050515 | molecular_function | 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A1271 |
| Chain | Residue |
| A | ASN86 |
| A | LYS254 |
| A | LYS262 |
| A | HOH2034 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A1272 |
| Chain | Residue |
| A | SER168 |
| A | SER170 |
| A | ARG173 |
| A | TYR216 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A1273 |
| Chain | Residue |
| A | ASN206 |
| A | PHE234 |
| A | VAL235 |
| A | GLU205 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B1271 |
| Chain | Residue |
| B | ARG213 |
| B | ARG224 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B1272 |
| Chain | Residue |
| B | PRO217 |
| B | GLU218 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B1273 |
| Chain | Residue |
| B | GLU205 |
| B | ASN206 |
| B | PHE234 |
| B | VAL235 |
| site_id | AC7 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE CDM A1269 |
| Chain | Residue |
| A | LYS9 |
| A | ASN11 |
| A | LEU14 |
| A | TYR24 |
| A | HIS25 |
| A | TYR31 |
| A | SER97 |
| A | SER128 |
| A | ALA129 |
| A | ASP130 |
| A | LYS145 |
| A | THR171 |
| A | TYR175 |
| A | ADP1270 |
| A | HOH2083 |
| A | HOH2085 |
| A | HOH2171 |
| A | HOH2172 |
| site_id | AC8 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE ADP A1270 |
| Chain | Residue |
| A | GLU59 |
| A | ASN60 |
| A | LEU61 |
| A | LYS85 |
| A | PRO89 |
| A | GLY90 |
| A | ALA91 |
| A | GLY92 |
| A | LEU93 |
| A | GLY94 |
| A | GLY95 |
| A | GLY96 |
| A | ASN99 |
| A | THR171 |
| A | CDM1269 |
| A | HOH2171 |
| A | HOH2173 |
| A | HOH2174 |
| A | HOH2175 |
| A | HOH2176 |
| site_id | AC9 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE CDM B1269 |
| Chain | Residue |
| B | LYS9 |
| B | ASN11 |
| B | LEU14 |
| B | TYR24 |
| B | HIS25 |
| B | SER128 |
| B | ALA129 |
| B | ASP130 |
| B | GLY172 |
| B | TYR175 |
| B | HOH2125 |
| B | HOH2126 |
| site_id | BC1 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE ADP B1270 |
| Chain | Residue |
| B | SER-1 |
| B | GLU59 |
| B | ASN60 |
| B | LEU61 |
| B | LYS85 |
| B | PRO88 |
| B | PRO89 |
| B | GLY90 |
| B | ALA91 |
| B | GLY92 |
| B | LEU93 |
| B | GLY94 |
| B | GLY95 |
| B | GLY96 |
| B | ASN99 |
| B | THR171 |
| B | HOH2029 |
| B | HOH2042 |
| B | HOH2069 |
| B | HOH2127 |
| B | HOH2128 |
| B | HOH2129 |
| B | HOH2130 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00061","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00061","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1oj4 |
| Chain | Residue | Details |
| A | ASP130 | |
| A | LYS9 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1oj4 |
| Chain | Residue | Details |
| B | ASP130 | |
| B | LYS9 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1oj4 |
| Chain | Residue | Details |
| A | THR171 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1oj4 |
| Chain | Residue | Details |
| B | THR171 |
