2V16

Crystal Structure of Renin with Inhibitor 3

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0004190	molecular_function	aspartic-type endopeptidase activity
C	0006508	biological_process	proteolysis
O	0004190	molecular_function	aspartic-type endopeptidase activity
O	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE C47 C1327

Chain	Residue
C	THR12
C	THR77
C	PRO111
C	PHE117
C	ASP215
C	THR216
C	GLY217
C	ALA218
C	SER219
C	HOH2015
C	GLN13
C	VAL30
C	ASP32
C	GLY34
C	SER35
C	ARG74
C	TYR75
C	SER76

---

site_id	AC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE C47 O1327

Chain	Residue
O	THR12
O	GLN13
O	ASP32
O	GLY34
O	SER35
O	ARG74
O	TYR75
O	SER76
O	THR77
O	PRO111
O	LEU114
O	ALA115
O	ILE130
O	ASP215
O	THR216
O	GLY217
O	ALA218
O	SER219

---

Functional Information from PROSITE/UniProt

site_id	PS00141
Number of Residues	12
Details	ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. VVFDTGSSNVWV

Chain	Residue	Details
C	VAL29-VAL40
C	ALA212-GLY223

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: ACT_SITE => ECO:0000269|PubMed:20927107

Chain	Residue	Details
C	ASP32
C	ASP215
O	ASP32
O	ASP215

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2493678

Chain	Residue	Details
C	ASN-1
C	ASN67
O	ASN-1
O	ASN67

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
C	ASP215
C	SER35
C	ALA218
C	ASP32

---

site_id	CSA10
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
O	ASP215
O	ALA218
O	ASP32
O	THR33

---

site_id	CSA11
Number of Residues	1
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
C	ASP32

---

site_id	CSA12
Number of Residues	1
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
O	ASP32

---

site_id	CSA13
Number of Residues	1
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
C	ASP215

---

site_id	CSA14
Number of Residues	1
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
O	ASP215

---

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
O	ASP215
O	SER35
O	ALA218
O	ASP32

---

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
C	ASP215
C	THR216
C	ASP32
C	THR33

---

site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
O	ASP215
O	THR216
O	ASP32
O	THR33

---

site_id	CSA5
Number of Residues	3
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
C	ASP215
C	SER35
C	ASP32

---

site_id	CSA6
Number of Residues	3
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
O	ASP215
O	SER35
O	ASP32

---

site_id	CSA7
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
C	ASP215
C	TYR75
C	SER35
C	ASP32

---

site_id	CSA8
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
O	ASP215
O	TYR75
O	SER35
O	ASP32

---

site_id	CSA9
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
C	ASP215
C	ALA218
C	ASP32
C	THR33

---