Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2UZP

Crystal structure of the C2 domain of human protein kinase C gamma.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DSN A -1

Chain	Residue
A	MET0
A	HIS154
A	PLP1294
A	CO1295
A	HOH2134
B	ARG249

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DSN B -1

Chain	Residue
B	PLP1294
B	CO1295
B	HOH2099
C	ARG249
A	GLU237
B	MET0
B	HIS154

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE DSN C -1

Chain	Residue
A	LYS232
A	ARG249
C	MET0
C	HIS154
C	PLP1294
C	CO1295
C	HOH2114
C	HOH2120

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CO A 1295

Chain	Residue
A	DSN-1
A	MET0
A	HIS154
A	PLP1294
A	HOH2134

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 1296

Chain	Residue
A	ASP187
A	ASP193
A	ASP246
A	TRP247
A	ASP248
A	HOH2036

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 1297

Chain	Residue
A	MET186
A	ASP187
A	ASP246
A	ASP248
A	ASP254
A	SO41299

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 1298

Chain	Residue
A	ASP248
A	SER251
A	ARG252
A	ASP254
B	HOH2075
B	HOH2076

site_id	AC8
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SO4 A 1299

Chain	Residue
A	MET186
A	ASP187
A	PRO188
A	ASP248
A	SER251
A	ASP254
A	CA1297
A	HOH2098
A	HOH2135
A	HOH2136
B	ARG158
B	HOH2075

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 1300

Chain	Residue
A	ARG239
A	PHE261
A	GLY262
A	GLU265
A	ASN287
A	HOH2138
A	HOH2140

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 1301

Chain	Residue
A	ARG157
A	ARG158
A	ASN279
A	HOH2122
A	HOH2141
A	HOH2142
A	HOH2143

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 1302

Chain	Residue
A	TYR195
A	LYS197
A	LYS209
A	LYS211
A	ASN253
A	EDO1305

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1303

Chain	Residue
A	TRP245
A	ARG252
A	GLN280
A	HOH2118
A	HOH2145

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 1304

Chain	Residue
A	MET0
A	HIS154
A	THR155
A	ARG157
A	LYS276
A	HOH2134

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CO B 1295

Chain	Residue
B	DSN-1
B	MET0
B	HIS154
B	PLP1294
B	HOH2099

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 1296

Chain	Residue
A	HOH2101
A	HOH2102
B	ASP248
B	SER251
B	ARG252
B	ASP254

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 1297

Chain	Residue
B	ASP193
B	ASP246
B	TRP247
B	ASP248
B	HOH2028
B	ASP187

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 1298

Chain	Residue
B	MET186
B	ASP187
B	ASP246
B	ASP248
B	ASP254
B	SO41299

site_id	BC9
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SO4 B 1299

Chain	Residue
A	ARG158
A	PHE255
A	HOH2102
B	MET186
B	ASP187
B	PRO188
B	ASP248
B	SER251
B	CA1298
B	HOH2073
B	HOH2100
B	HOH2101

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 1300

Chain	Residue
B	ARG239
B	GLY262
B	GLU265
B	ASN287
B	HOH2103

site_id	CC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 B 1301

Chain	Residue
B	ARG181
B	ASN182
B	HOH2105
B	HOH2106
B	HOH2107
B	HOH2108
C	THR218
C	HOH2053

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 1302

Chain	Residue
B	MET0
B	HIS154
B	THR155
B	ARG157
B	LYS276

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 1303

Chain	Residue
A	ARG252
B	TRP245
B	ARG252
B	GLN280
B	HOH2087
B	HOH2110

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 1304

Chain	Residue
B	TYR195
B	LYS209
B	LYS211
B	EDO1307

site_id	CC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 1305

Chain	Residue
B	ARG157
B	ARG158
B	ASN279
C	ARG157

site_id	CC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CO C 1295

Chain	Residue
C	DSN-1
C	MET0
C	HIS154
C	PLP1294
C	HOH2114

site_id	CC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 1296

Chain	Residue
C	ASP187
C	ASP193
C	ASP246
C	TRP247
C	ASP248
C	HOH2029

site_id	CC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 1297

Chain	Residue
C	ASP248
C	SER251
C	ARG252
C	ASP254
C	HOH2084
C	HOH2085

site_id	DC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 1298

Chain	Residue
C	MET186
C	ASP187
C	ASP246
C	ASP248
C	ASP254
C	SO41299

site_id	DC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SO4 C 1299

Chain	Residue
C	ARG158
C	MET186
C	ASP187
C	PRO188
C	ASP248
C	SER251
C	PHE255
C	CA1298
C	HOH2080
C	HOH2084
C	HOH2115
C	HOH2117

site_id	DC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 C 1300

Chain	Residue
A	HOH2018
A	HOH2019
C	ARG239
C	PHE261
C	GLY262
C	GLU265
C	ASN287
C	HOH2118

site_id	DC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 C 1301

Chain	Residue
C	MET0
C	HIS154
C	THR155
C	ARG157
C	LYS276
C	HOH2120

site_id	DC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 1302

Chain	Residue
B	ARG157
C	ARG157
C	ARG158
C	ASN279
C	HOH2122

site_id	DC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 1303

Chain	Residue
C	TYR195
C	LYS197
C	LYS209
C	LYS211
C	EDO1308

site_id	DC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 C 1304

Chain	Residue
C	TRP245
C	ARG252
C	GLN280
C	HOH2074
C	HOH2081
C	HOH2124

site_id	DC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 C 1305

Chain	Residue
A	THR218
A	HOH2061
A	HOH2062
C	ARG181
C	ASN182
C	HOH2054
C	HOH2126
C	HOH2127
C	HOH2128

site_id	DC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PLP A 1294

Chain	Residue
A	DSN-1
A	MET0
A	HIS154
A	ALA291
A	CO1295
A	HOH2134
B	LYS216
B	ARG249

site_id	EC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1305

Chain	Residue
A	TYR195
A	LYS197
A	ARG252
A	SO41302
A	EDO1306

site_id	EC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 1306

Chain	Residue
A	ARG252
A	ASN253
A	EDO1305

site_id	EC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PLP B 1294

Chain	Residue
B	DSN-1
B	MET0
B	HIS154
B	ALA291
B	CO1295
B	HOH2099
C	LYS216
C	TRP247
C	ARG249
C	EDO1307

site_id	EC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO B 1306

Chain	Residue
A	HIS154
A	GLU156
B	ASN189
B	ASP193
B	HOH2113
B	HOH2114

site_id	EC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO B 1307

Chain	Residue
B	LYS197
B	TRP245
B	ARG252
B	SO41304
B	HOH2115

site_id	EC6
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PLP C 1294

Chain	Residue
A	LYS216
A	TRP247
A	ARG249
C	DSN-1
C	MET0
C	HIS154
C	THR155
C	ALA291
C	CO1295
C	EDO1306
C	HOH2112
C	HOH2114

site_id	EC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO C 1306

Chain	Residue
A	ASN189
A	ASP193
A	LYS216
C	HIS154
C	GLU156
C	PLP1294
C	HOH2129
C	HOH2130

site_id	EC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO C 1307

Chain	Residue
B	THR155
B	GLU156
B	PLP1294
C	ASN189
C	ASP193
C	ALA217
C	HOH2131
C	HOH2132

site_id	EC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO C 1308

Chain	Residue
C	LYS197
C	ARG252
C	SO41303
C	EDO1309

site_id	FC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO C 1309

Chain	Residue
C	ARG252
C	ASN253
C	EDO1308

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	27
Details	BINDING: BINDING => ECO:0000269\|Ref.14

Chain	Residue	Details
A	MET186
B	MET186
B	ASP187
B	ASP193
B	ASP246
B	TRP247
B	ASP248
B	SER251
B	ARG252
B	ASP254
C	MET186
A	ASP187
C	ASP187
C	ASP193
C	ASP246
C	TRP247
C	ASP248
C	SER251
C	ARG252
C	ASP254
A	ASP193
A	ASP246
A	TRP247
A	ASP248
A	SER251
A	ARG252
A	ASP254

site_id	SWS_FT_FI2
Number of Residues	3
Details	MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000250

Chain	Residue	Details
A	THR250
B	THR250
C	THR250

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)