2UZP
Crystal structure of the C2 domain of human protein kinase C gamma.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0004674 | molecular_function | protein serine/threonine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
| C | 0004674 | molecular_function | protein serine/threonine kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DSN A -1 |
| Chain | Residue |
| A | MET0 |
| A | HIS154 |
| A | PLP1294 |
| A | CO1295 |
| A | HOH2134 |
| B | ARG249 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DSN B -1 |
| Chain | Residue |
| B | PLP1294 |
| B | CO1295 |
| B | HOH2099 |
| C | ARG249 |
| A | GLU237 |
| B | MET0 |
| B | HIS154 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE DSN C -1 |
| Chain | Residue |
| A | LYS232 |
| A | ARG249 |
| C | MET0 |
| C | HIS154 |
| C | PLP1294 |
| C | CO1295 |
| C | HOH2114 |
| C | HOH2120 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CO A 1295 |
| Chain | Residue |
| A | DSN-1 |
| A | MET0 |
| A | HIS154 |
| A | PLP1294 |
| A | HOH2134 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1296 |
| Chain | Residue |
| A | ASP187 |
| A | ASP193 |
| A | ASP246 |
| A | TRP247 |
| A | ASP248 |
| A | HOH2036 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1297 |
| Chain | Residue |
| A | MET186 |
| A | ASP187 |
| A | ASP246 |
| A | ASP248 |
| A | ASP254 |
| A | SO41299 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1298 |
| Chain | Residue |
| A | ASP248 |
| A | SER251 |
| A | ARG252 |
| A | ASP254 |
| B | HOH2075 |
| B | HOH2076 |
| site_id | AC8 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1299 |
| Chain | Residue |
| A | MET186 |
| A | ASP187 |
| A | PRO188 |
| A | ASP248 |
| A | SER251 |
| A | ASP254 |
| A | CA1297 |
| A | HOH2098 |
| A | HOH2135 |
| A | HOH2136 |
| B | ARG158 |
| B | HOH2075 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1300 |
| Chain | Residue |
| A | ARG239 |
| A | PHE261 |
| A | GLY262 |
| A | GLU265 |
| A | ASN287 |
| A | HOH2138 |
| A | HOH2140 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1301 |
| Chain | Residue |
| A | ARG157 |
| A | ARG158 |
| A | ASN279 |
| A | HOH2122 |
| A | HOH2141 |
| A | HOH2142 |
| A | HOH2143 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1302 |
| Chain | Residue |
| A | TYR195 |
| A | LYS197 |
| A | LYS209 |
| A | LYS211 |
| A | ASN253 |
| A | EDO1305 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1303 |
| Chain | Residue |
| A | TRP245 |
| A | ARG252 |
| A | GLN280 |
| A | HOH2118 |
| A | HOH2145 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1304 |
| Chain | Residue |
| A | MET0 |
| A | HIS154 |
| A | THR155 |
| A | ARG157 |
| A | LYS276 |
| A | HOH2134 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CO B 1295 |
| Chain | Residue |
| B | DSN-1 |
| B | MET0 |
| B | HIS154 |
| B | PLP1294 |
| B | HOH2099 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 1296 |
| Chain | Residue |
| A | HOH2101 |
| A | HOH2102 |
| B | ASP248 |
| B | SER251 |
| B | ARG252 |
| B | ASP254 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 1297 |
| Chain | Residue |
| B | ASP193 |
| B | ASP246 |
| B | TRP247 |
| B | ASP248 |
| B | HOH2028 |
| B | ASP187 |
| site_id | BC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 1298 |
| Chain | Residue |
| B | MET186 |
| B | ASP187 |
| B | ASP246 |
| B | ASP248 |
| B | ASP254 |
| B | SO41299 |
| site_id | BC9 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1299 |
| Chain | Residue |
| A | ARG158 |
| A | PHE255 |
| A | HOH2102 |
| B | MET186 |
| B | ASP187 |
| B | PRO188 |
| B | ASP248 |
| B | SER251 |
| B | CA1298 |
| B | HOH2073 |
| B | HOH2100 |
| B | HOH2101 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1300 |
| Chain | Residue |
| B | ARG239 |
| B | GLY262 |
| B | GLU265 |
| B | ASN287 |
| B | HOH2103 |
| site_id | CC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1301 |
| Chain | Residue |
| B | ARG181 |
| B | ASN182 |
| B | HOH2105 |
| B | HOH2106 |
| B | HOH2107 |
| B | HOH2108 |
| C | THR218 |
| C | HOH2053 |
| site_id | CC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1302 |
| Chain | Residue |
| B | MET0 |
| B | HIS154 |
| B | THR155 |
| B | ARG157 |
| B | LYS276 |
| site_id | CC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1303 |
| Chain | Residue |
| A | ARG252 |
| B | TRP245 |
| B | ARG252 |
| B | GLN280 |
| B | HOH2087 |
| B | HOH2110 |
| site_id | CC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1304 |
| Chain | Residue |
| B | TYR195 |
| B | LYS209 |
| B | LYS211 |
| B | EDO1307 |
| site_id | CC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1305 |
| Chain | Residue |
| B | ARG157 |
| B | ARG158 |
| B | ASN279 |
| C | ARG157 |
| site_id | CC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CO C 1295 |
| Chain | Residue |
| C | DSN-1 |
| C | MET0 |
| C | HIS154 |
| C | PLP1294 |
| C | HOH2114 |
| site_id | CC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA C 1296 |
| Chain | Residue |
| C | ASP187 |
| C | ASP193 |
| C | ASP246 |
| C | TRP247 |
| C | ASP248 |
| C | HOH2029 |
| site_id | CC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA C 1297 |
| Chain | Residue |
| C | ASP248 |
| C | SER251 |
| C | ARG252 |
| C | ASP254 |
| C | HOH2084 |
| C | HOH2085 |
| site_id | DC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA C 1298 |
| Chain | Residue |
| C | MET186 |
| C | ASP187 |
| C | ASP246 |
| C | ASP248 |
| C | ASP254 |
| C | SO41299 |
| site_id | DC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1299 |
| Chain | Residue |
| C | ARG158 |
| C | MET186 |
| C | ASP187 |
| C | PRO188 |
| C | ASP248 |
| C | SER251 |
| C | PHE255 |
| C | CA1298 |
| C | HOH2080 |
| C | HOH2084 |
| C | HOH2115 |
| C | HOH2117 |
| site_id | DC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1300 |
| Chain | Residue |
| A | HOH2018 |
| A | HOH2019 |
| C | ARG239 |
| C | PHE261 |
| C | GLY262 |
| C | GLU265 |
| C | ASN287 |
| C | HOH2118 |
| site_id | DC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1301 |
| Chain | Residue |
| C | MET0 |
| C | HIS154 |
| C | THR155 |
| C | ARG157 |
| C | LYS276 |
| C | HOH2120 |
| site_id | DC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1302 |
| Chain | Residue |
| B | ARG157 |
| C | ARG157 |
| C | ARG158 |
| C | ASN279 |
| C | HOH2122 |
| site_id | DC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1303 |
| Chain | Residue |
| C | TYR195 |
| C | LYS197 |
| C | LYS209 |
| C | LYS211 |
| C | EDO1308 |
| site_id | DC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1304 |
| Chain | Residue |
| C | TRP245 |
| C | ARG252 |
| C | GLN280 |
| C | HOH2074 |
| C | HOH2081 |
| C | HOH2124 |
| site_id | DC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1305 |
| Chain | Residue |
| A | THR218 |
| A | HOH2061 |
| A | HOH2062 |
| C | ARG181 |
| C | ASN182 |
| C | HOH2054 |
| C | HOH2126 |
| C | HOH2127 |
| C | HOH2128 |
| site_id | DC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PLP A 1294 |
| Chain | Residue |
| A | DSN-1 |
| A | MET0 |
| A | HIS154 |
| A | ALA291 |
| A | CO1295 |
| A | HOH2134 |
| B | LYS216 |
| B | ARG249 |
| site_id | EC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 1305 |
| Chain | Residue |
| A | TYR195 |
| A | LYS197 |
| A | ARG252 |
| A | SO41302 |
| A | EDO1306 |
| site_id | EC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 1306 |
| Chain | Residue |
| A | ARG252 |
| A | ASN253 |
| A | EDO1305 |
| site_id | EC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PLP B 1294 |
| Chain | Residue |
| B | DSN-1 |
| B | MET0 |
| B | HIS154 |
| B | ALA291 |
| B | CO1295 |
| B | HOH2099 |
| C | LYS216 |
| C | TRP247 |
| C | ARG249 |
| C | EDO1307 |
| site_id | EC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 1306 |
| Chain | Residue |
| A | HIS154 |
| A | GLU156 |
| B | ASN189 |
| B | ASP193 |
| B | HOH2113 |
| B | HOH2114 |
| site_id | EC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 1307 |
| Chain | Residue |
| B | LYS197 |
| B | TRP245 |
| B | ARG252 |
| B | SO41304 |
| B | HOH2115 |
| site_id | EC6 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PLP C 1294 |
| Chain | Residue |
| A | LYS216 |
| A | TRP247 |
| A | ARG249 |
| C | DSN-1 |
| C | MET0 |
| C | HIS154 |
| C | THR155 |
| C | ALA291 |
| C | CO1295 |
| C | EDO1306 |
| C | HOH2112 |
| C | HOH2114 |
| site_id | EC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO C 1306 |
| Chain | Residue |
| A | ASN189 |
| A | ASP193 |
| A | LYS216 |
| C | HIS154 |
| C | GLU156 |
| C | PLP1294 |
| C | HOH2129 |
| C | HOH2130 |
| site_id | EC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO C 1307 |
| Chain | Residue |
| B | THR155 |
| B | GLU156 |
| B | PLP1294 |
| C | ASN189 |
| C | ASP193 |
| C | ALA217 |
| C | HOH2131 |
| C | HOH2132 |
| site_id | EC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO C 1308 |
| Chain | Residue |
| C | LYS197 |
| C | ARG252 |
| C | SO41303 |
| C | EDO1309 |
| site_id | FC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO C 1309 |
| Chain | Residue |
| C | ARG252 |
| C | ASN253 |
| C | EDO1308 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 354 |
| Details | Domain: {"description":"C2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00041","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 27 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"APR-2007","submissionDatabase":"PDB data bank","title":"Crystal structure of C2 domain of protein kinase C gamma.","authors":["Pike A.C.W.","Amos A.","Johansson C.","Sobott F.","Savitsky P.","Berridge G.","Fedorov O.","Umeano C.","Gorrec F.","Bunkoczi G.","Debreczeni J.","Von Delft F.","Arrowsmith C.H.","Edwards A.","Weigelt J.","Sundstrom M.","Knapp S."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Phosphothreonine; by autocatalysis","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
