2UZF
Crystal structure of Staphylococcus aureus 1,4-dihydroxy-2-naphthoyl CoA synthase (MenB) in complex with acetoacetyl CoA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005829 | cellular_component | cytosol |
| A | 0008935 | molecular_function | 1,4-dihydroxy-2-naphthoyl-CoA synthase activity |
| A | 0009234 | biological_process | menaquinone biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0008935 | molecular_function | 1,4-dihydroxy-2-naphthoyl-CoA synthase activity |
| B | 0009234 | biological_process | menaquinone biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE CAA A 1274 |
| Chain | Residue |
| A | VAL33 |
| A | SER149 |
| A | HOH2015 |
| A | HOH2027 |
| B | PHE258 |
| A | ARG34 |
| A | SER73 |
| A | GLY75 |
| A | ASP76 |
| A | TYR117 |
| A | GLY121 |
| A | THR143 |
| A | VAL147 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: in other chain => ECO:0000255|HAMAP-Rule:MF_01934, ECO:0000269|PubMed:18007038 |
| Chain | Residue | Details |
| A | ARG34 | |
| A | SER73 | |
| A | SER149 | |
| B | ARG34 | |
| B | SER73 | |
| B | SER149 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: in other chain => ECO:0000250|UniProtKB:P0ABU0, ECO:0000255|HAMAP-Rule:MF_01934 |
| Chain | Residue | Details |
| A | TYR85 | |
| A | TYR117 | |
| A | THR143 | |
| B | TYR85 | |
| B | TYR117 | |
| B | THR143 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P0ABU0, ECO:0000255|HAMAP-Rule:MF_01934 |
| Chain | Residue | Details |
| A | GLN142 | |
| A | TYR246 | |
| A | LYS261 | |
| B | GLN142 | |
| B | TYR246 | |
| B | LYS261 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | SITE: Important for catalysis => ECO:0000250|UniProtKB:P0ABU0, ECO:0000255|HAMAP-Rule:MF_01934 |
| Chain | Residue | Details |
| A | TYR85 | |
| A | TYR246 | |
| B | TYR85 | |
| B | TYR246 |
