2UZ8

The crystal structure of p18, human translation elongation factor 1 epsilon 1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006412	biological_process	translation
A	0008285	biological_process	negative regulation of cell population proliferation
A	0017101	cellular_component	aminoacyl-tRNA synthetase multienzyme complex
A	0043065	biological_process	positive regulation of apoptotic process
A	0043517	biological_process	positive regulation of DNA damage response, signal transduction by p53 class mediator
A	1990830	biological_process	cellular response to leukemia inhibitory factor
A	2000774	biological_process	positive regulation of cellular senescence
A	2001235	biological_process	positive regulation of apoptotic signaling pathway
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006412	biological_process	translation
B	0008285	biological_process	negative regulation of cell population proliferation
B	0017101	cellular_component	aminoacyl-tRNA synthetase multienzyme complex
B	0043065	biological_process	positive regulation of apoptotic process
B	0043517	biological_process	positive regulation of DNA damage response, signal transduction by p53 class mediator
B	1990830	biological_process	cellular response to leukemia inhibitory factor
B	2000774	biological_process	positive regulation of cellular senescence
B	2001235	biological_process	positive regulation of apoptotic signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A1171

Chain	Residue
A	LYS136
A	LEU140
A	PHE164
A	ILE165
A	HOH2060
A	HOH2075
A	HOH2078

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL B1171

Chain	Residue
B	ILE165
B	HOH2051
B	HOH2073
B	HOH2074
B	HOH2075
B	LYS136
B	LEU140

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Region: {"description":"Linker"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Lilla S.","von Kriegsheim A.","Lempens A.","Kolch W."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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