2UYY

Structure of the cytokine-like nuclear factor n-pac

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016491	molecular_function	oxidoreductase activity
A	0050661	molecular_function	NADP binding
A	0051287	molecular_function	NAD binding
B	0016491	molecular_function	oxidoreductase activity
B	0050661	molecular_function	NADP binding
B	0051287	molecular_function	NAD binding
C	0016491	molecular_function	oxidoreductase activity
C	0050661	molecular_function	NADP binding
C	0051287	molecular_function	NAD binding
D	0016491	molecular_function	oxidoreductase activity
D	0050661	molecular_function	NADP binding
D	0051287	molecular_function	NAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K A1554

Chain	Residue
A	GLY397
A	GLN418
A	ALA419
A	GLY421
A	HOH2039

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K B1554

Chain	Residue
B	HOH2033
B	GLY397
B	GLN418
B	ALA419
B	GLY421

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K C1554

Chain	Residue
C	GLY397
C	GLN418
C	ALA419
C	GLY421
C	HOH2035
C	HOH2045

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K D1554

Chain	Residue
D	GLY397
D	GLN418
D	ALA419
D	GLY421
D	HOH2044

---

site_id	AC5
Number of Residues	19
Details	BINDING SITE FOR RESIDUE NA7 A1555

Chain	Residue
A	GLY276
A	LEU277
A	MET278
A	ASN297
A	ARG298
A	THR299
A	LYS302
A	CYS330
A	VAL331
A	SER332
A	ALA336
A	ASP339
A	THR362
A	TYR499
A	TYR502
A	LYS505
A	HOH2089
A	HOH2090
A	HOH2091

---

site_id	AC6
Number of Residues	20
Details	BINDING SITE FOR RESIDUE NA7 D1555

Chain	Residue
D	LEU275
D	GLY276
D	LEU277
D	MET278
D	ASN297
D	ARG298
D	THR299
D	CYS330
D	VAL331
D	SER332
D	ALA336
D	ASP339
D	THR362
D	PHE498
D	TYR499
D	TYR502
D	LYS505
D	HOH2100
D	HOH2101
D	HOH2102

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	64
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"APR-2007","submissionDatabase":"PDB data bank","title":"The structure of the cytokine-like nuclear factor N-PAC.","authors":["Tickle J.","Pilka E.S.","Bunkoczi G.","Berridge G.","Smee C.","Kavanagh K.L.","Hozjan V.","Niesen F.H.","Papagrigoriou E.","Pike A.C.W.","Turnbull A.","Arrowsmith C.H.","Edwards A.","Sundstrom M.","Weigelt J.","Von Delft F.","Oppermann U."]}},{"source":"PDB","id":"2UYY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25772364","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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