2UYX

metallo-beta-lactamase (1BC2) single point mutant D120S

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008270	molecular_function	zinc ion binding
A	0008800	molecular_function	beta-lactamase activity
A	0017001	biological_process	antibiotic catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL A1292

Chain	Residue
A	HIS118
A	HOH2280
A	HOH2281
A	SER120
A	HIS196
A	GOL1293
A	ZN1296
A	ZN1297
A	HOH2277
A	HOH2278
A	HOH2279

---

site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL A1293

Chain	Residue
A	HIS118
A	ALA119
A	SER120
A	CYS221
A	GOL1292
A	ZN1296
A	ZN1297
A	HOH2277
A	HOH2279
A	HOH2280
A	HOH2281

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A1294

Chain	Residue
A	ALA117
A	HIS118
A	ASN149
A	THR197
A	ASP199
A	ASP236

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A1295

Chain	Residue
A	GLU97
A	GLU130
A	ARG131
A	HOH2077

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN A1296

Chain	Residue
A	HIS116
A	HIS118
A	HIS196
A	GOL1292
A	GOL1293
A	HOH2281

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN A1297

Chain	Residue
A	CYS221
A	HIS263
A	GOL1292
A	GOL1293
A	HOH2280
A	HOH2283

---

Functional Information from PROSITE/UniProt

site_id	PS00744
Number of Residues	13
Details	BETA_LACTAMASE_B_2 Beta-lactamases class B signature 2. PqynILvGgCLVK

Chain	Residue	Details
A	PRO209-LYS224

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20677753","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24059435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26482303","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7588620","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9761898","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20677753","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24059435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26482303","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26482303","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26482303","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9761898","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1qh5

Chain	Residue	Details
A	SER120

---

site_id	MCSA1
Number of Residues	5
Details	M-CSA 16

Chain	Residue	Details
A	HIS116	metal ligand
A	HIS118	metal ligand
A	SER120	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
A	HIS196	metal ligand
A	ASN233	electrostatic stabiliser, hydrogen bond donor

---