2UXQ
Isocitrate dehydrogenase from the psychrophilic bacterium Desulfotalea psychrophila: biochemical properties and crystal structure analysis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004450 | molecular_function | isocitrate dehydrogenase (NADP+) activity |
| A | 0006099 | biological_process | tricarboxylic acid cycle |
| A | 0006102 | biological_process | isocitrate metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051287 | molecular_function | NAD binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004450 | molecular_function | isocitrate dehydrogenase (NADP+) activity |
| B | 0006099 | biological_process | tricarboxylic acid cycle |
| B | 0006102 | biological_process | isocitrate metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051287 | molecular_function | NAD binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0004450 | molecular_function | isocitrate dehydrogenase (NADP+) activity |
| C | 0006099 | biological_process | tricarboxylic acid cycle |
| C | 0006102 | biological_process | isocitrate metabolic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0051287 | molecular_function | NAD binding |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0004450 | molecular_function | isocitrate dehydrogenase (NADP+) activity |
| D | 0006099 | biological_process | tricarboxylic acid cycle |
| D | 0006102 | biological_process | isocitrate metabolic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL C1403 |
| Chain | Residue |
| C | LEU285 |
| C | HIS305 |
| C | THR323 |
| C | ASN324 |
| C | HOH2437 |
| C | HOH2438 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B1402 |
| Chain | Residue |
| B | ASN324 |
| B | HOH2497 |
| B | HOH2498 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A1403 |
| Chain | Residue |
| A | SER284 |
| A | LEU285 |
| A | ALA286 |
| A | ASN324 |
| A | HOH2427 |
| A | HOH2464 |
| A | HOH2465 |
| A | HOH2466 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL D1403 |
| Chain | Residue |
| D | GLY306 |
| D | THR307 |
| D | VAL308 |
| D | GLN309 |
| D | GOL1404 |
| D | HOH2446 |
| D | HOH2448 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL D1404 |
| Chain | Residue |
| D | THR323 |
| D | ASN324 |
| D | GOL1403 |
| D | HOH2447 |
| D | HOH2448 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A1404 |
| Chain | Residue |
| A | ASP15 |
| A | GLU16 |
| A | GLY44 |
| A | ILE45 |
| A | GLU46 |
| A | TYR85 |
| A | HOH2467 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL D1405 |
| Chain | Residue |
| D | ASN95 |
| D | ARG99 |
| D | ARG131 |
| D | ASP272 |
| D | GLU302 |
| D | SO41407 |
| D | HOH2321 |
| D | HOH2324 |
| D | HOH2449 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A1405 |
| Chain | Residue |
| A | ARG99 |
| A | ARG131 |
| A | ASP272 |
| A | GLU302 |
| A | SO41406 |
| A | MG1407 |
| A | HOH2468 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL C1404 |
| Chain | Residue |
| C | ASP15 |
| C | GLU16 |
| C | GLY44 |
| C | ILE45 |
| C | GLU46 |
| C | TYR85 |
| C | HOH2440 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL C1405 |
| Chain | Residue |
| C | ARG99 |
| C | ARG131 |
| C | ASP272 |
| C | GLU302 |
| C | SO41407 |
| C | HOH2442 |
| site_id | BC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B1403 |
| Chain | Residue |
| A | GLN218 |
| A | LYS221 |
| B | ASN78 |
| B | GLN79 |
| B | GLN90 |
| B | HOH2500 |
| B | HOH2501 |
| B | HOH2502 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B1404 |
| Chain | Residue |
| B | HIS311 |
| B | GLN314 |
| B | SER322 |
| B | HOH2404 |
| B | HOH2503 |
| site_id | BC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 C1406 |
| Chain | Residue |
| C | ASN78 |
| C | GLN79 |
| C | GLN90 |
| C | HOH2122 |
| C | HOH2443 |
| D | GLN218 |
| D | LYS221 |
| D | HOH2264 |
| site_id | BC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 D1406 |
| Chain | Residue |
| C | ASP210 |
| C | GLN218 |
| C | HOH2264 |
| D | ASN78 |
| D | GLN79 |
| D | GLN90 |
| D | HOH2450 |
| D | HOH2451 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B1405 |
| Chain | Residue |
| B | ASN95 |
| B | ARG99 |
| B | GLU302 |
| B | SO41406 |
| B | HOH2164 |
| site_id | BC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B1406 |
| Chain | Residue |
| A | LYS209 |
| A | HOH2282 |
| B | THR76 |
| B | SER93 |
| B | ASN95 |
| B | SO41405 |
| B | HOH2223 |
| B | HOH2504 |
| site_id | BC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A1406 |
| Chain | Residue |
| A | THR76 |
| A | SER93 |
| A | ASN95 |
| A | GOL1405 |
| A | HOH2468 |
| A | HOH2469 |
| A | HOH2470 |
| B | HOH2306 |
| site_id | BC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 C1407 |
| Chain | Residue |
| C | THR76 |
| C | SER93 |
| C | ASN95 |
| C | GOL1405 |
| C | HOH2442 |
| C | HOH2444 |
| C | HOH2445 |
| D | HOH2265 |
| site_id | CC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 D1407 |
| Chain | Residue |
| C | HOH2267 |
| D | THR76 |
| D | SER93 |
| D | ASN95 |
| D | GOL1405 |
| D | HOH2449 |
| D | HOH2452 |
| site_id | CC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B1407 |
| Chain | Residue |
| B | GLY306 |
| B | THR307 |
| B | VAL308 |
| B | GLN309 |
| B | HOH2505 |
| B | HOH2506 |
| B | HOH2507 |
| B | HOH2508 |
| site_id | CC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A1407 |
| Chain | Residue |
| A | ASP272 |
| A | ASP276 |
| A | GOL1405 |
| A | HOH2345 |
| B | ASP249 |
| site_id | CC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PEG A1408 |
| Chain | Residue |
| A | GLU46 |
| A | GLU84 |
| A | TYR85 |
| A | TYR313 |
| A | LEU316 |
| A | HOH2471 |
| A | HOH2472 |
| A | HOH2473 |
| site_id | CC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG B1408 |
| Chain | Residue |
| B | TYR85 |
| B | TYR313 |
| B | LEU316 |
| B | HOH2509 |
| site_id | CC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG C1408 |
| Chain | Residue |
| C | GLU84 |
| C | TYR85 |
| C | TYR313 |
| C | LEU316 |
| site_id | CC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PEG C1409 |
| Chain | Residue |
| C | ALA100 |
| C | MET101 |
| C | ASP103 |
| C | TYR134 |
| C | THR182 |
| C | TYR296 |
| C | TYR298 |
| D | GLU172 |
| site_id | CC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG B1409 |
| Chain | Residue |
| B | GLU39 |
| B | TYR40 |
| B | TYR41 |
| B | HOH2512 |
Functional Information from PROSITE/UniProt
| site_id | PS00470 |
| Number of Residues | 20 |
| Details | IDH_IMDH Isocitrate and isopropylmalate dehydrogenases signature. NYDGDVmSDmvAsaf.GSLAM |
| Chain | Residue | Details |
| A | ASN268-MET287 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1a05 |
| Chain | Residue | Details |
| A | VAL154 |
| site_id | CSA10 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1a05 |
| Chain | Residue | Details |
| B | PHE144 |
| site_id | CSA11 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1a05 |
| Chain | Residue | Details |
| C | PHE144 |
| site_id | CSA12 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1a05 |
| Chain | Residue | Details |
| D | PHE144 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1a05 |
| Chain | Residue | Details |
| B | VAL154 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1a05 |
| Chain | Residue | Details |
| C | VAL154 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1a05 |
| Chain | Residue | Details |
| D | VAL154 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a05 |
| Chain | Residue | Details |
| A | LYS209 | |
| A | ASP249 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a05 |
| Chain | Residue | Details |
| B | LYS209 | |
| B | ASP249 |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a05 |
| Chain | Residue | Details |
| C | LYS209 | |
| C | ASP249 |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a05 |
| Chain | Residue | Details |
| D | LYS209 | |
| D | ASP249 |
| site_id | CSA9 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1a05 |
| Chain | Residue | Details |
| A | PHE144 |
