2UXO

TtgR in complex with Tetracycline

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0001217	molecular_function	DNA-binding transcription repressor activity
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0032993	cellular_component	protein-DNA complex
A	0045892	biological_process	negative regulation of DNA-templated transcription
B	0000976	molecular_function	transcription cis-regulatory region binding
B	0001217	molecular_function	DNA-binding transcription repressor activity
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0006355	biological_process	regulation of DNA-templated transcription
B	0032993	cellular_component	protein-DNA complex
B	0045892	biological_process	negative regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE TAC B1211

Chain	Residue
B	LEU66
B	HOH2010
B	HOH2029
B	HOH2041
B	HOH2073
B	HOH2074
B	HOH2075
B	LEU92
B	VAL96
B	ASN110
B	LEU113
B	CYS137
B	ILE141
B	PHE168
B	VAL171

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Functional Information from PROSITE/UniProt

site_id	PS01081
Number of Residues	32
Details	HTH_TETR_1 TetR-type HTH domain signature. GVartTLadIaelagVTrGaIYwHFnNKaelV

Chain	Residue	Details
A	GLY28-VAL59

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	38
Details	DNA_BIND: H-T-H motif => ECO:0000255|PROSITE-ProRule:PRU00335

Chain	Residue	Details
A	THR33-PHE52
B	THR33-PHE52

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