Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006508 | biological_process | proteolysis |
| A | 0007596 | biological_process | blood coagulation |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0006508 | biological_process | proteolysis |
| B | 0007596 | biological_process | blood coagulation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA B 2248 |
| Chain | Residue |
| B | ARG221 |
| B | LYS224 |
| B | HOH1224 |
| B | HOH1227 |
| B | HOH1242 |
| B | HOH1268 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 2249 |
| Chain | Residue |
| B | HOH1201 |
| B | HOH1212 |
| B | HOH1252 |
| B | LYS169 |
| B | THR172 |
| B | PHE204 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE 897 B 2250 |
| Chain | Residue |
| B | HIS57 |
| B | TYR60 |
| B | TRP60 |
| B | GLU97 |
| B | ASP189 |
| B | ALA190 |
| B | CYS191 |
| B | SER195 |
| B | VAL213 |
| B | SER214 |
| B | TRP215 |
| B | GLY216 |
| B | GLY226 |
| B | HOH1278 |
| B | HOH1291 |
| B | HOH1292 |
| B | HOH1293 |
| B | HOH1294 |
| site_id | AC4 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR CHAIN H OF HIRUDIN I |
| Chain | Residue |
| B | PHE34 |
| B | GLN38 |
| B | LEU40 |
| B | LEU65 |
| B | ARG73 |
| B | THR74 |
| B | ARG75 |
| B | ARG75 |
| B | TYR76 |
| B | GLU80 |
| B | LYS81 |
| B | ILE82 |
| B | HOH1050 |
| B | HOH1051 |
| B | HOH1101 |
| B | HOH1116 |
| H | HOH1001 |
| H | HOH1002 |
| H | HOH1003 |
| H | HOH1004 |
| H | HOH1005 |
| H | HOH1006 |
| H | HOH1007 |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC |
| Chain | Residue | Details |
| B | LEU53-CYS58 | |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV |
| Chain | Residue | Details |
| B | ASP189-VAL200 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| H | TYS63 | |
| B | ASP102 | |
| B | SER195 | |
| Chain | Residue | Details |
| B | ASN60 | |
