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2UU7

Crystal structure of apo glutamine synthetase from dog (Canis familiaris)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0001525biological_processangiogenesis
A0003824molecular_functioncatalytic activity
A0004356molecular_functionglutamine synthetase activity
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006542biological_processglutamine biosynthetic process
A0010594biological_processregulation of endothelial cell migration
A0016740molecular_functiontransferase activity
A0016874molecular_functionligase activity
A0018345biological_processprotein palmitoylation
A0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
A0045648biological_processpositive regulation of erythrocyte differentiation
A0046872molecular_functionmetal ion binding
A0097275biological_processintracellular ammonium homeostasis
A1903670biological_processregulation of sprouting angiogenesis
B0000166molecular_functionnucleotide binding
B0001525biological_processangiogenesis
B0003824molecular_functioncatalytic activity
B0004356molecular_functionglutamine synthetase activity
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006542biological_processglutamine biosynthetic process
B0010594biological_processregulation of endothelial cell migration
B0016740molecular_functiontransferase activity
B0016874molecular_functionligase activity
B0018345biological_processprotein palmitoylation
B0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
B0045648biological_processpositive regulation of erythrocyte differentiation
B0046872molecular_functionmetal ion binding
B0097275biological_processintracellular ammonium homeostasis
B1903670biological_processregulation of sprouting angiogenesis
C0000166molecular_functionnucleotide binding
C0001525biological_processangiogenesis
C0003824molecular_functioncatalytic activity
C0004356molecular_functionglutamine synthetase activity
C0005524molecular_functionATP binding
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006542biological_processglutamine biosynthetic process
C0010594biological_processregulation of endothelial cell migration
C0016740molecular_functiontransferase activity
C0016874molecular_functionligase activity
C0018345biological_processprotein palmitoylation
C0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
C0045648biological_processpositive regulation of erythrocyte differentiation
C0046872molecular_functionmetal ion binding
C0097275biological_processintracellular ammonium homeostasis
C1903670biological_processregulation of sprouting angiogenesis
D0000166molecular_functionnucleotide binding
D0001525biological_processangiogenesis
D0003824molecular_functioncatalytic activity
D0004356molecular_functionglutamine synthetase activity
D0005524molecular_functionATP binding
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006542biological_processglutamine biosynthetic process
D0010594biological_processregulation of endothelial cell migration
D0016740molecular_functiontransferase activity
D0016874molecular_functionligase activity
D0018345biological_processprotein palmitoylation
D0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
D0045648biological_processpositive regulation of erythrocyte differentiation
D0046872molecular_functionmetal ion binding
D0097275biological_processintracellular ammonium homeostasis
D1903670biological_processregulation of sprouting angiogenesis
E0000166molecular_functionnucleotide binding
E0001525biological_processangiogenesis
E0003824molecular_functioncatalytic activity
E0004356molecular_functionglutamine synthetase activity
E0005524molecular_functionATP binding
E0005737cellular_componentcytoplasm
E0005739cellular_componentmitochondrion
E0005829cellular_componentcytosol
E0005886cellular_componentplasma membrane
E0006542biological_processglutamine biosynthetic process
E0010594biological_processregulation of endothelial cell migration
E0016740molecular_functiontransferase activity
E0016874molecular_functionligase activity
E0018345biological_processprotein palmitoylation
E0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
E0045648biological_processpositive regulation of erythrocyte differentiation
E0046872molecular_functionmetal ion binding
E0097275biological_processintracellular ammonium homeostasis
E1903670biological_processregulation of sprouting angiogenesis
F0000166molecular_functionnucleotide binding
F0001525biological_processangiogenesis
F0003824molecular_functioncatalytic activity
F0004356molecular_functionglutamine synthetase activity
F0005524molecular_functionATP binding
F0005737cellular_componentcytoplasm
F0005739cellular_componentmitochondrion
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0006542biological_processglutamine biosynthetic process
F0010594biological_processregulation of endothelial cell migration
F0016740molecular_functiontransferase activity
F0016874molecular_functionligase activity
F0018345biological_processprotein palmitoylation
F0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
F0045648biological_processpositive regulation of erythrocyte differentiation
F0046872molecular_functionmetal ion binding
F0097275biological_processintracellular ammonium homeostasis
F1903670biological_processregulation of sprouting angiogenesis
G0000166molecular_functionnucleotide binding
G0001525biological_processangiogenesis
G0003824molecular_functioncatalytic activity
G0004356molecular_functionglutamine synthetase activity
G0005524molecular_functionATP binding
G0005737cellular_componentcytoplasm
G0005739cellular_componentmitochondrion
G0005829cellular_componentcytosol
G0005886cellular_componentplasma membrane
G0006542biological_processglutamine biosynthetic process
G0010594biological_processregulation of endothelial cell migration
G0016740molecular_functiontransferase activity
G0016874molecular_functionligase activity
G0018345biological_processprotein palmitoylation
G0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
G0045648biological_processpositive regulation of erythrocyte differentiation
G0046872molecular_functionmetal ion binding
G0097275biological_processintracellular ammonium homeostasis
G1903670biological_processregulation of sprouting angiogenesis
H0000166molecular_functionnucleotide binding
H0001525biological_processangiogenesis
H0003824molecular_functioncatalytic activity
H0004356molecular_functionglutamine synthetase activity
H0005524molecular_functionATP binding
H0005737cellular_componentcytoplasm
H0005739cellular_componentmitochondrion
H0005829cellular_componentcytosol
H0005886cellular_componentplasma membrane
H0006542biological_processglutamine biosynthetic process
H0010594biological_processregulation of endothelial cell migration
H0016740molecular_functiontransferase activity
H0016874molecular_functionligase activity
H0018345biological_processprotein palmitoylation
H0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
H0045648biological_processpositive regulation of erythrocyte differentiation
H0046872molecular_functionmetal ion binding
H0097275biological_processintracellular ammonium homeostasis
H1903670biological_processregulation of sprouting angiogenesis
I0000166molecular_functionnucleotide binding
I0001525biological_processangiogenesis
I0003824molecular_functioncatalytic activity
I0004356molecular_functionglutamine synthetase activity
I0005524molecular_functionATP binding
I0005737cellular_componentcytoplasm
I0005739cellular_componentmitochondrion
I0005829cellular_componentcytosol
I0005886cellular_componentplasma membrane
I0006542biological_processglutamine biosynthetic process
I0010594biological_processregulation of endothelial cell migration
I0016740molecular_functiontransferase activity
I0016874molecular_functionligase activity
I0018345biological_processprotein palmitoylation
I0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
I0045648biological_processpositive regulation of erythrocyte differentiation
I0046872molecular_functionmetal ion binding
I0097275biological_processintracellular ammonium homeostasis
I1903670biological_processregulation of sprouting angiogenesis
J0000166molecular_functionnucleotide binding
J0001525biological_processangiogenesis
J0003824molecular_functioncatalytic activity
J0004356molecular_functionglutamine synthetase activity
J0005524molecular_functionATP binding
J0005737cellular_componentcytoplasm
J0005739cellular_componentmitochondrion
J0005829cellular_componentcytosol
J0005886cellular_componentplasma membrane
J0006542biological_processglutamine biosynthetic process
J0010594biological_processregulation of endothelial cell migration
J0016740molecular_functiontransferase activity
J0016874molecular_functionligase activity
J0018345biological_processprotein palmitoylation
J0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
J0045648biological_processpositive regulation of erythrocyte differentiation
J0046872molecular_functionmetal ion binding
J0097275biological_processintracellular ammonium homeostasis
J1903670biological_processregulation of sprouting angiogenesis
K0000166molecular_functionnucleotide binding
K0001525biological_processangiogenesis
K0003824molecular_functioncatalytic activity
K0004356molecular_functionglutamine synthetase activity
K0005524molecular_functionATP binding
K0005737cellular_componentcytoplasm
K0005739cellular_componentmitochondrion
K0005829cellular_componentcytosol
K0005886cellular_componentplasma membrane
K0006542biological_processglutamine biosynthetic process
K0010594biological_processregulation of endothelial cell migration
K0016740molecular_functiontransferase activity
K0016874molecular_functionligase activity
K0018345biological_processprotein palmitoylation
K0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
K0045648biological_processpositive regulation of erythrocyte differentiation
K0046872molecular_functionmetal ion binding
K0097275biological_processintracellular ammonium homeostasis
K1903670biological_processregulation of sprouting angiogenesis
L0000166molecular_functionnucleotide binding
L0001525biological_processangiogenesis
L0003824molecular_functioncatalytic activity
L0004356molecular_functionglutamine synthetase activity
L0005524molecular_functionATP binding
L0005737cellular_componentcytoplasm
L0005739cellular_componentmitochondrion
L0005829cellular_componentcytosol
L0005886cellular_componentplasma membrane
L0006542biological_processglutamine biosynthetic process
L0010594biological_processregulation of endothelial cell migration
L0016740molecular_functiontransferase activity
L0016874molecular_functionligase activity
L0018345biological_processprotein palmitoylation
L0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
L0045648biological_processpositive regulation of erythrocyte differentiation
L0046872molecular_functionmetal ion binding
L0097275biological_processintracellular ammonium homeostasis
L1903670biological_processregulation of sprouting angiogenesis
M0000166molecular_functionnucleotide binding
M0001525biological_processangiogenesis
M0003824molecular_functioncatalytic activity
M0004356molecular_functionglutamine synthetase activity
M0005524molecular_functionATP binding
M0005737cellular_componentcytoplasm
M0005739cellular_componentmitochondrion
M0005829cellular_componentcytosol
M0005886cellular_componentplasma membrane
M0006542biological_processglutamine biosynthetic process
M0010594biological_processregulation of endothelial cell migration
M0016740molecular_functiontransferase activity
M0016874molecular_functionligase activity
M0018345biological_processprotein palmitoylation
M0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
M0045648biological_processpositive regulation of erythrocyte differentiation
M0046872molecular_functionmetal ion binding
M0097275biological_processintracellular ammonium homeostasis
M1903670biological_processregulation of sprouting angiogenesis
N0000166molecular_functionnucleotide binding
N0001525biological_processangiogenesis
N0003824molecular_functioncatalytic activity
N0004356molecular_functionglutamine synthetase activity
N0005524molecular_functionATP binding
N0005737cellular_componentcytoplasm
N0005739cellular_componentmitochondrion
N0005829cellular_componentcytosol
N0005886cellular_componentplasma membrane
N0006542biological_processglutamine biosynthetic process
N0010594biological_processregulation of endothelial cell migration
N0016740molecular_functiontransferase activity
N0016874molecular_functionligase activity
N0018345biological_processprotein palmitoylation
N0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
N0045648biological_processpositive regulation of erythrocyte differentiation
N0046872molecular_functionmetal ion binding
N0097275biological_processintracellular ammonium homeostasis
N1903670biological_processregulation of sprouting angiogenesis
O0000166molecular_functionnucleotide binding
O0001525biological_processangiogenesis
O0003824molecular_functioncatalytic activity
O0004356molecular_functionglutamine synthetase activity
O0005524molecular_functionATP binding
O0005737cellular_componentcytoplasm
O0005739cellular_componentmitochondrion
O0005829cellular_componentcytosol
O0005886cellular_componentplasma membrane
O0006542biological_processglutamine biosynthetic process
O0010594biological_processregulation of endothelial cell migration
O0016740molecular_functiontransferase activity
O0016874molecular_functionligase activity
O0018345biological_processprotein palmitoylation
O0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
O0045648biological_processpositive regulation of erythrocyte differentiation
O0046872molecular_functionmetal ion binding
O0097275biological_processintracellular ammonium homeostasis
O1903670biological_processregulation of sprouting angiogenesis
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL A1373
ChainResidue
AMET29
ALYS43
ATHR44
BTHR193

site_idAC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CL B1373
ChainResidue
BTHR44
CTHR193

site_idAC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL C1373
ChainResidue
CLYS43
CTHR44
DTHR193

site_idAC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL D1373
ChainResidue
DMET29
DTHR44
ETHR193

site_idAC5
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CL E1373
ChainResidue
ATHR193
ETHR44

site_idAC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL F1373
ChainResidue
FLYS43
FTHR44
GTHR193

site_idAC7
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL G1373
ChainResidue
GMET29
GTHR44
HTHR193

site_idAC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL H1373
ChainResidue
HMET29
HLYS43
HTHR44
ITHR193

site_idAC9
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL I1373
ChainResidue
IMET29
ITHR44
JTHR193

site_idBC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL J1373
ChainResidue
FTHR193
JMET29
JLYS43
JTHR44

site_idBC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL K1373
ChainResidue
KMET29
KLYS43
KTHR44
LTHR193

site_idBC3
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CL L1373
ChainResidue
LMET29
LTHR44

site_idBC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL M1373
ChainResidue
MMET29
MTHR44
NTHR193

site_idBC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL N1373
ChainResidue
NMET29
NTHR44
OTHR193

site_idBC6
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CL O1373
ChainResidue
KTHR193
OTHR44

site_idBC7
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG A 401
ChainResidue
AGLU136
AGLU196
AGLU203

site_idBC8
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG B 401
ChainResidue
BGLU136
BGLU196
BGLU203

site_idBC9
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG C 401
ChainResidue
CGLU136
CGLU196
CGLU203

site_idCC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG D 401
ChainResidue
DGLU136
DGLU196
DGLU203

site_idCC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG E 401
ChainResidue
EGLU136
EGLU196
EGLU203

site_idCC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG F 401
ChainResidue
FGLU136
FGLU196
FGLU203

site_idCC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG G 401
ChainResidue
GGLU134
GGLU136
GGLU196
GGLU203

site_idCC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG H 401
ChainResidue
HGLU136
HGLU196
HGLU203

site_idCC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG I 401
ChainResidue
IGLU136
IGLU196
IGLU203

site_idCC7
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG J 401
ChainResidue
JGLU136
JGLU196
JGLU203

site_idCC8
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG K 401
ChainResidue
KGLU136
KGLU196
KGLU203

site_idCC9
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG L 401
ChainResidue
LGLU136
LGLU196
LGLU203

site_idDC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG M 401
ChainResidue
MGLU136
MGLU196
MGLU203

site_idDC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG N 401
ChainResidue
NGLU134
NGLU136
NGLU196
NGLU203

site_idDC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG O 401
ChainResidue
OGLU136
OGLU196
OGLU203

Functional Information from PROSITE/UniProt
site_idPS00180
Number of Residues18
DetailsGLNA_1 Glutamine synthetase signature 1. FDGSStfqsegs.NSDmyL
ChainResidueDetails
APHE62-LEU79

site_idPS00181
Number of Residues17
DetailsGLNA_ATP Glutamine synthetase putative ATP-binding region signature. KPIpgnw.NGAGcHtnfS
ChainResidueDetails
ALYS241-SER257

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1230
DetailsDomain: {"description":"GS beta-grasp","evidences":[{"source":"PROSITE-ProRule","id":"PRU01330","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues195
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P15104","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues45
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"18005987","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2UU7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues45
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P9WN39","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues30
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P15104","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues15
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P15105","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues15
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P15104","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

Catalytic Information from CSA
site_idCSA1
Number of Residues3
DetailsAnnotated By Reference To The Literature 1hto
ChainResidueDetails
AARG319
AGLU305
AASP63

site_idCSA10
Number of Residues3
DetailsAnnotated By Reference To The Literature 1hto
ChainResidueDetails
JARG319
JGLU305
JASP63

site_idCSA11
Number of Residues3
DetailsAnnotated By Reference To The Literature 1hto
ChainResidueDetails
KARG319
KGLU305
KASP63

site_idCSA12
Number of Residues3
DetailsAnnotated By Reference To The Literature 1hto
ChainResidueDetails
LARG319
LGLU305
LASP63

site_idCSA13
Number of Residues3
DetailsAnnotated By Reference To The Literature 1hto
ChainResidueDetails
MARG319
MGLU305
MASP63

site_idCSA14
Number of Residues3
DetailsAnnotated By Reference To The Literature 1hto
ChainResidueDetails
NARG319
NGLU305
NASP63

site_idCSA15
Number of Residues3
DetailsAnnotated By Reference To The Literature 1hto
ChainResidueDetails
OARG319
OGLU305
OASP63

site_idCSA2
Number of Residues3
DetailsAnnotated By Reference To The Literature 1hto
ChainResidueDetails
BARG319
BGLU305
BASP63

site_idCSA3
Number of Residues3
DetailsAnnotated By Reference To The Literature 1hto
ChainResidueDetails
CARG319
CGLU305
CASP63

site_idCSA4
Number of Residues3
DetailsAnnotated By Reference To The Literature 1hto
ChainResidueDetails
DARG319
DGLU305
DASP63

site_idCSA5
Number of Residues3
DetailsAnnotated By Reference To The Literature 1hto
ChainResidueDetails
EARG319
EGLU305
EASP63

site_idCSA6
Number of Residues3
DetailsAnnotated By Reference To The Literature 1hto
ChainResidueDetails
FARG319
FGLU305
FASP63

site_idCSA7
Number of Residues3
DetailsAnnotated By Reference To The Literature 1hto
ChainResidueDetails
GARG319
GGLU305
GASP63

site_idCSA8
Number of Residues3
DetailsAnnotated By Reference To The Literature 1hto
ChainResidueDetails
HARG319
HGLU305
HASP63

site_idCSA9
Number of Residues3
DetailsAnnotated By Reference To The Literature 1hto
ChainResidueDetails
IARG319
IGLU305
IASP63

243083

PDB entries from 2025-10-15

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