2TPR
X-RAY STRUCTURE OF TRYPANOTHIONE REDUCTASE FROM CRITHIDIA FASCICULATA AT 2.4 ANGSTROMS RESOLUTION
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004362 | molecular_function | glutathione-disulfide reductase (NADPH) activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0006749 | biological_process | glutathione metabolic process |
| A | 0015036 | molecular_function | disulfide oxidoreductase activity |
| A | 0015042 | molecular_function | trypanothione-disulfide reductase (NADPH) activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| A | 0034599 | biological_process | cellular response to oxidative stress |
| A | 0045454 | biological_process | cell redox homeostasis |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| B | 0004362 | molecular_function | glutathione-disulfide reductase (NADPH) activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005829 | cellular_component | cytosol |
| B | 0006749 | biological_process | glutathione metabolic process |
| B | 0015036 | molecular_function | disulfide oxidoreductase activity |
| B | 0015042 | molecular_function | trypanothione-disulfide reductase (NADPH) activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| B | 0034599 | biological_process | cellular response to oxidative stress |
| B | 0045454 | biological_process | cell redox homeostasis |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0098869 | biological_process | cellular oxidant detoxification |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 38 |
| Details | BINDING SITE FOR RESIDUE FAD A 500 |
| Chain | Residue |
| A | ILE9 |
| A | ALA46 |
| A | GLY49 |
| A | THR50 |
| A | CYS51 |
| A | GLY55 |
| A | CYS56 |
| A | LYS59 |
| A | GLY124 |
| A | GLY126 |
| A | ALA158 |
| A | GLY10 |
| A | THR159 |
| A | GLY160 |
| A | TYR197 |
| A | ARG286 |
| A | ARG289 |
| A | LEU293 |
| A | GLY325 |
| A | ASP326 |
| A | MET332 |
| A | LEU333 |
| A | GLY12 |
| A | THR334 |
| A | PRO335 |
| A | ALA337 |
| A | HOH501 |
| A | HOH502 |
| A | HOH508 |
| A | HOH542 |
| A | HOH640 |
| B | HIS460 |
| A | SER13 |
| A | GLY14 |
| A | ILE33 |
| A | ASP34 |
| A | LEU35 |
| A | ALA45 |
| site_id | AC2 |
| Number of Residues | 37 |
| Details | BINDING SITE FOR RESIDUE FAD B 500 |
| Chain | Residue |
| A | HIS460 |
| B | ILE9 |
| B | GLY10 |
| B | GLY12 |
| B | SER13 |
| B | GLY14 |
| B | ILE33 |
| B | ASP34 |
| B | LEU35 |
| B | ALA46 |
| B | GLY49 |
| B | THR50 |
| B | CYS51 |
| B | VAL54 |
| B | CYS56 |
| B | LYS59 |
| B | GLY124 |
| B | GLY126 |
| B | ALA158 |
| B | THR159 |
| B | GLY160 |
| B | TYR197 |
| B | ARG286 |
| B | ARG289 |
| B | GLY325 |
| B | ASP326 |
| B | MET332 |
| B | LEU333 |
| B | THR334 |
| B | PRO335 |
| B | ALA337 |
| B | HOH501 |
| B | HOH506 |
| B | HOH518 |
| B | HOH570 |
| B | HOH670 |
| B | HOH691 |
Functional Information from PROSITE/UniProt
| site_id | PS00076 |
| Number of Residues | 11 |
| Details | PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCVnvGCVP |
| Chain | Residue | Details |
| A | GLY48-PRO58 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor |
| Chain | Residue | Details |
| A | HIS460 | |
| B | HIS460 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ASP34 | |
| B | ASP34 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 7 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| A | GLU465 | |
| A | HIS460 | |
| B | CYS51 | |
| B | GLU201 | |
| B | CYS56 | |
| B | TYR197 | |
| B | LYS59 |
| site_id | CSA2 |
| Number of Residues | 7 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| A | CYS51 | |
| A | GLU201 | |
| A | CYS56 | |
| A | LYS59 | |
| A | TYR197 | |
| B | GLU465 | |
| B | HIS460 |
