2TMK
YEAST THYMIDYLATE KINASE COMPLEXED WITH 3'-AZIDO-3'-DEOXYTHYMIDINE MONOPHOSPHATE (AZT-MP)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
| A | 0004798 | molecular_function | thymidylate kinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006227 | biological_process | dUDP biosynthetic process |
| A | 0006233 | biological_process | dTDP biosynthetic process |
| A | 0006235 | biological_process | dTTP biosynthetic process |
| A | 0009041 | molecular_function | UMP/dUMP kinase activity |
| A | 0009165 | biological_process | nucleotide biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
| B | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
| B | 0004798 | molecular_function | thymidylate kinase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006227 | biological_process | dUDP biosynthetic process |
| B | 0006233 | biological_process | dTDP biosynthetic process |
| B | 0006235 | biological_process | dTTP biosynthetic process |
| B | 0009041 | molecular_function | UMP/dUMP kinase activity |
| B | 0009165 | biological_process | nucleotide biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 218 |
| Chain | Residue |
| A | LEU13 |
| A | ASP14 |
| A | ARG15 |
| A | THR16 |
| A | GLY17 |
| A | LYS18 |
| A | THR19 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SO4 B 218 |
| Chain | Residue |
| B | ARG15 |
| B | THR16 |
| B | GLY17 |
| B | LYS18 |
| B | THR19 |
| B | HOH1023 |
| B | HOH1105 |
| B | HOH1197 |
| B | HOH1204 |
| B | LEU13 |
| B | ASP14 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE ATM A 217 |
| Chain | Residue |
| A | ASP14 |
| A | LYS37 |
| A | PHE38 |
| A | ARG41 |
| A | PHE69 |
| A | ARG73 |
| A | ARG94 |
| A | GLY99 |
| A | TYR102 |
| A | ARG150 |
| A | TYR151 |
| A | GLU152 |
| A | HOH1122 |
| A | HOH1123 |
| A | HOH1140 |
| A | HOH1143 |
| site_id | AC4 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE ATM B 217 |
| Chain | Residue |
| B | ASP14 |
| B | LYS37 |
| B | PHE38 |
| B | PRO39 |
| B | ARG41 |
| B | LEU53 |
| B | PHE69 |
| B | ARG73 |
| B | ARG94 |
| B | GLY99 |
| B | TYR102 |
| B | GLU149 |
| B | TYR151 |
| B | GLU152 |
| B | GLN157 |
| B | HOH1016 |
| B | HOH1017 |
| B | HOH1024 |
| B | HOH1204 |
Functional Information from PROSITE/UniProt
| site_id | PS01331 |
| Number of Residues | 13 |
| Details | THYMIDYLATE_KINASE Thymidylate kinase signature. VMDRYvySGvAYS |
| Chain | Residue | Details |
| A | VAL91-SER103 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000305 |
| Chain | Residue | Details |
| A | GLY12 | |
| B | GLY12 |
