2SIL
THE STRUCTURES OF SALMONELLA TYPHIMURIUM LT2 NEURAMINIDASE AND ITS COMPLEX WITH A TRANSITION STATE ANALOGUE AT 1.6 ANGSTROMS RESOLUTION
Replaces: 1SILFunctional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004308 | molecular_function | exo-alpha-sialidase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0006689 | biological_process | ganglioside catabolic process |
A | 0009313 | biological_process | oligosaccharide catabolic process |
A | 0016020 | cellular_component | membrane |
A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
A | 0052794 | molecular_function | exo-alpha-(2->3)-sialidase activity |
A | 0052795 | molecular_function | exo-alpha-(2->6)-sialidase activity |
A | 0052796 | molecular_function | exo-alpha-(2->8)-sialidase activity |
Functional Information from PDB Data
site_id | ACT |
Number of Residues | 13 |
Details |
Chain | Residue |
A | ARG37 |
A | ARG246 |
A | ARG309 |
A | TYR342 |
A | GLU361 |
A | ARG56 |
A | ASP62 |
A | MET99 |
A | ASP100 |
A | TRP121 |
A | TRP128 |
A | LEU175 |
A | GLU231 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Proton acceptor => ECO:0000250 |
Chain | Residue | Details |
A | GLN63 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | ACT_SITE: Nucleophile => ECO:0000250 |
Chain | Residue | Details |
A | SER343 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | ACT_SITE: |
Chain | Residue | Details |
A | ALA362 |
site_id | SWS_FT_FI4 |
Number of Residues | 3 |
Details | BINDING: |
Chain | Residue | Details |
A | ILE38 | |
A | ASN247 | |
A | SER310 |