2RUR

Solution structure of Human Pin1 PPIase C113S mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity

Functional Information from PROSITE/UniProt

site_id	PS01096
Number of Residues	21
Details	PPIC_PPIASE_1 PpiC-type peptidyl-prolyl cis-trans isomerase signature. FEsLAsqfSdss.Saka..RGdLG

Chain	Residue	Details
A	PHE57-GLY77

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine; by DAPK1 => ECO:0000269|PubMed:21497122, ECO:0000269|PubMed:29686383

Chain	Residue	Details
A	SER25

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17525332

Chain	Residue	Details
A	SER62

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	5
Details	M-CSA 511

Chain	Residue	Details
A	HIS13	proton shuttle (general acid/base)
A	SER67	covalently attached, electrostatic stabiliser
A	GLN85	electrostatic stabiliser
A	SER108	electrostatic stabiliser
A	HIS111	electrostatic stabiliser

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