2RTU
Solution structure of oxidized human HMGB1 A box
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS00353 |
| Number of Residues | 12 |
| Details | HMG_BOX_1 HMG box A DNA-binding domain signature. FSKKCsERWKTM |
| Chain | Residue | Details |
| A | PHE44-MET55 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 70 |
| Details | DNA_BIND: HMG box 1 => ECO:0000255|PROSITE-ProRule:PRU00267 |
| Chain | Residue | Details |
| A | PRO12-ILE82 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P10103 |
| Chain | Residue | Details |
| A | MET4 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by thrombin:thrombomodulin => ECO:0000250|UniProtKB:P10103 |
| Chain | Residue | Details |
| A | ARG13 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by CASP1 => ECO:0000269|PubMed:24474694 |
| Chain | Residue | Details |
| A | ASP70 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P10103 |
| Chain | Residue | Details |
| A | LYS6 | |
| A | LYS10 | |
| A | LYS11 | |
| A | LYS15 | |
| A | LYS31 | |
| A | LYS32 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Cysteine sulfonic acid (-SO3H); alternate => ECO:0000250|UniProtKB:P63159 |
| Chain | Residue | Details |
| A | CYS26 | |
| A | CYS48 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS33 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER38 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P63158 |
| Chain | Residue | Details |
| A | LYS46 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 5 |
| Details | CROSSLNK: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?) => ECO:0000269|PubMed:29618516 |
| Chain | Residue | Details |
| A | LYS31 | |
| A | LYS46 | |
| A | LYS47 | |
| A | LYS71 |
