2RRD

Structure of HRDC domain from human Bloom syndrome protein, BLM

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003676	molecular_function	nucleic acid binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	Domain: {"description":"HRDC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00328","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20639533","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20639533","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	17
Details	Region: {"description":"Necessary for ssDNA and DNA Holliday junction binding","evidences":[{"source":"PubMed","id":"20639533","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25901030","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4CDG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4CGZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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