2RLF
Proton Channel M2 from Influenza A in complex with inhibitor rimantadine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0015078 | molecular_function | proton transmembrane transporter activity |
| A | 0033644 | cellular_component | host cell membrane |
| A | 0055036 | cellular_component | virion membrane |
| A | 1902600 | biological_process | proton transmembrane transport |
| B | 0015078 | molecular_function | proton transmembrane transporter activity |
| B | 0033644 | cellular_component | host cell membrane |
| B | 0055036 | cellular_component | virion membrane |
| B | 1902600 | biological_process | proton transmembrane transport |
| C | 0015078 | molecular_function | proton transmembrane transporter activity |
| C | 0033644 | cellular_component | host cell membrane |
| C | 0055036 | cellular_component | virion membrane |
| C | 1902600 | biological_process | proton transmembrane transport |
| D | 0015078 | molecular_function | proton transmembrane transporter activity |
| D | 0033644 | cellular_component | host cell membrane |
| D | 0055036 | cellular_component | virion membrane |
| D | 1902600 | biological_process | proton transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE RIM A 199 |
| Chain | Residue |
| A | ASP44 |
| B | ARG45 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE RIM B 299 |
| Chain | Residue |
| B | LEU40 |
| B | ASP44 |
| C | TRP41 |
| C | ARG45 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE RIM C 399 |
| Chain | Residue |
| D | ARG45 |
| C | LEU40 |
| C | LEU43 |
| C | ASP44 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE RIM D 499 |
| Chain | Residue |
| A | ARG45 |
| D | LEU40 |
| D | ASP44 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Signal-anchor for type III membrane protein => ECO:0000255|HAMAP-Rule:MF_04069 |
| Chain | Residue | Details |
| A | SER23-LEU43 | |
| B | SER23-LEU43 | |
| C | SER23-LEU43 | |
| D | SER23-LEU43 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | SITE: Essential for channel activity, possibly by being protonated during channel activation, and by forming the channel gate and the selective filter => ECO:0000255|HAMAP-Rule:MF_04069 |
| Chain | Residue | Details |
| A | HIS37 | |
| B | HIS37 | |
| C | HIS37 | |
| D | HIS37 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | SITE: Seems to be involved in pH gating => ECO:0000255|HAMAP-Rule:MF_04069 |
| Chain | Residue | Details |
| A | TRP41 | |
| B | TRP41 | |
| C | TRP41 | |
| D | TRP41 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | LIPID: S-palmitoyl cysteine; by host => ECO:0000255|HAMAP-Rule:MF_04069 |
| Chain | Residue | Details |
| A | SER50 | |
| B | SER50 | |
| C | SER50 | |
| D | SER50 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04069 |
| Chain | Residue | Details |
| A | ASN20 | |
| B | ASN20 | |
| C | ASN20 | |
| D | ASN20 |
