2RIQ
Crystal Structure of the Third Zinc-binding domain of human PARP-1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008270 | molecular_function | zinc ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1 |
| Chain | Residue |
| A | CYS295 |
| A | CYS298 |
| A | CYS311 |
| A | CYS321 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EOH A 2 |
| Chain | Residue |
| A | PHE339 |
| A | ILE342 |
| A | LEU348 |
| A | HOH379 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 3 |
| Chain | Residue |
| A | ASN247 |
| A | ILE248 |
| A | LYS346 |
| A | LYS347 |
| A | VAL350 |
| A | HOH466 |
| A | HOH514 |
| A | HOH517 |
| A | LEU244 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 4 |
| Chain | Residue |
| A | ASN259 |
| A | GLU296 |
| A | VAL323 |
| A | PRO328 |
| A | ASN329 |
| A | HOH393 |
| A | HOH444 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 5 |
| Chain | Residue |
| A | TRP246 |
| A | LYS249 |
| A | ASP250 |
| A | LYS253 |
| A | HOH537 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 134 |
| Details | Domain: {"description":"PADR1 zinc-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU01351","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 42 |
| Details | Region: {"description":"Zinc ribbon","evidences":[{"source":"PROSITE-ProRule","id":"PRU01351","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01351","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18055453","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22582261","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2RIQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4DQY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OPX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OQA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OQB","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
