Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2RI4

Crystal Structure determination of Goat Methemoglobin at 2.7 Angstrom

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004601	molecular_function	peroxidase activity
A	0005344	molecular_function	oxygen carrier activity
A	0005506	molecular_function	iron ion binding
A	0005833	cellular_component	hemoglobin complex
A	0015671	biological_process	oxygen transport
A	0019825	molecular_function	oxygen binding
A	0020037	molecular_function	heme binding
A	0031720	molecular_function	haptoglobin binding
A	0031838	cellular_component	haptoglobin-hemoglobin complex
A	0042744	biological_process	hydrogen peroxide catabolic process
A	0043177	molecular_function	organic acid binding
A	0046872	molecular_function	metal ion binding
A	0072562	cellular_component	blood microparticle
A	0098869	biological_process	cellular oxidant detoxification
B	0004601	molecular_function	peroxidase activity
B	0005344	molecular_function	oxygen carrier activity
B	0005833	cellular_component	hemoglobin complex
B	0015671	biological_process	oxygen transport
B	0019825	molecular_function	oxygen binding
B	0020037	molecular_function	heme binding
B	0031720	molecular_function	haptoglobin binding
B	0031721	molecular_function	hemoglobin alpha binding
B	0031838	cellular_component	haptoglobin-hemoglobin complex
B	0042744	biological_process	hydrogen peroxide catabolic process
B	0043177	molecular_function	organic acid binding
B	0046872	molecular_function	metal ion binding
B	0072562	cellular_component	blood microparticle
B	0098869	biological_process	cellular oxidant detoxification
C	0004601	molecular_function	peroxidase activity
C	0005344	molecular_function	oxygen carrier activity
C	0005506	molecular_function	iron ion binding
C	0005833	cellular_component	hemoglobin complex
C	0015671	biological_process	oxygen transport
C	0019825	molecular_function	oxygen binding
C	0020037	molecular_function	heme binding
C	0031720	molecular_function	haptoglobin binding
C	0031838	cellular_component	haptoglobin-hemoglobin complex
C	0042744	biological_process	hydrogen peroxide catabolic process
C	0043177	molecular_function	organic acid binding
C	0046872	molecular_function	metal ion binding
C	0072562	cellular_component	blood microparticle
C	0098869	biological_process	cellular oxidant detoxification
D	0004601	molecular_function	peroxidase activity
D	0005344	molecular_function	oxygen carrier activity
D	0005833	cellular_component	hemoglobin complex
D	0015671	biological_process	oxygen transport
D	0019825	molecular_function	oxygen binding
D	0020037	molecular_function	heme binding
D	0031720	molecular_function	haptoglobin binding
D	0031721	molecular_function	hemoglobin alpha binding
D	0031838	cellular_component	haptoglobin-hemoglobin complex
D	0042744	biological_process	hydrogen peroxide catabolic process
D	0043177	molecular_function	organic acid binding
D	0046872	molecular_function	metal ion binding
D	0072562	cellular_component	blood microparticle
D	0098869	biological_process	cellular oxidant detoxification
I	0004601	molecular_function	peroxidase activity
I	0005344	molecular_function	oxygen carrier activity
I	0005506	molecular_function	iron ion binding
I	0005833	cellular_component	hemoglobin complex
I	0015671	biological_process	oxygen transport
I	0019825	molecular_function	oxygen binding
I	0020037	molecular_function	heme binding
I	0031720	molecular_function	haptoglobin binding
I	0031838	cellular_component	haptoglobin-hemoglobin complex
I	0042744	biological_process	hydrogen peroxide catabolic process
I	0043177	molecular_function	organic acid binding
I	0046872	molecular_function	metal ion binding
I	0072562	cellular_component	blood microparticle
I	0098869	biological_process	cellular oxidant detoxification
J	0004601	molecular_function	peroxidase activity
J	0005344	molecular_function	oxygen carrier activity
J	0005833	cellular_component	hemoglobin complex
J	0015671	biological_process	oxygen transport
J	0019825	molecular_function	oxygen binding
J	0020037	molecular_function	heme binding
J	0031720	molecular_function	haptoglobin binding
J	0031721	molecular_function	hemoglobin alpha binding
J	0031838	cellular_component	haptoglobin-hemoglobin complex
J	0042744	biological_process	hydrogen peroxide catabolic process
J	0043177	molecular_function	organic acid binding
J	0046872	molecular_function	metal ion binding
J	0072562	cellular_component	blood microparticle
J	0098869	biological_process	cellular oxidant detoxification
K	0004601	molecular_function	peroxidase activity
K	0005344	molecular_function	oxygen carrier activity
K	0005506	molecular_function	iron ion binding
K	0005833	cellular_component	hemoglobin complex
K	0015671	biological_process	oxygen transport
K	0019825	molecular_function	oxygen binding
K	0020037	molecular_function	heme binding
K	0031720	molecular_function	haptoglobin binding
K	0031838	cellular_component	haptoglobin-hemoglobin complex
K	0042744	biological_process	hydrogen peroxide catabolic process
K	0043177	molecular_function	organic acid binding
K	0046872	molecular_function	metal ion binding
K	0072562	cellular_component	blood microparticle
K	0098869	biological_process	cellular oxidant detoxification
L	0004601	molecular_function	peroxidase activity
L	0005344	molecular_function	oxygen carrier activity
L	0005833	cellular_component	hemoglobin complex
L	0015671	biological_process	oxygen transport
L	0019825	molecular_function	oxygen binding
L	0020037	molecular_function	heme binding
L	0031720	molecular_function	haptoglobin binding
L	0031721	molecular_function	hemoglobin alpha binding
L	0031838	cellular_component	haptoglobin-hemoglobin complex
L	0042744	biological_process	hydrogen peroxide catabolic process
L	0043177	molecular_function	organic acid binding
L	0046872	molecular_function	metal ion binding
L	0072562	cellular_component	blood microparticle
L	0098869	biological_process	cellular oxidant detoxification

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE HEM A 142

Chain	Residue
A	TYR42
A	ASN97
A	PHE98
A	LEU101
A	VAL132
A	PHE43
A	HIS58
A	LYS61
A	ALA65
A	LEU66
A	LEU86
A	HIS87
A	VAL93

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE HEM B 147

Chain	Residue
B	PHE41
B	PHE42
B	HIS63
B	VAL67
B	SER70
B	LEU88
B	HIS92
B	LEU96
B	VAL98
B	ASN102
B	LEU141
B	HOH149

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE HEM C 142

Chain	Residue
C	TYR42
C	PHE43
C	HIS58
C	LYS61
C	VAL62
C	LEU86
C	HIS87
C	LEU91
C	ASN97
C	PHE98
C	LEU101
C	LEU136
C	HOH145

site_id	AC4
Number of Residues	16
Details	BINDING SITE FOR RESIDUE HEM D 147

Chain	Residue
C	SER81
D	PHE41
D	PHE42
D	HIS63
D	LYS66
D	VAL67
D	SER70
D	PHE71
D	HIS92
D	LEU96
D	VAL98
D	ASN102
D	LEU106
D	LEU141
D	HOH149
D	HOH150

site_id	AC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE HEM I 142

Chain	Residue
I	TYR42
I	PHE43
I	HIS45
I	HIS58
I	LYS61
I	VAL62
I	LEU83
I	HIS87
I	ASN97
I	PHE98
I	LEU101
I	LEU136
I	HOH145
I	HOH146

site_id	AC6
Number of Residues	13
Details	BINDING SITE FOR RESIDUE HEM J 147

Chain	Residue
J	THR38
J	PHE42
J	HIS63
J	LYS66
J	SER70
J	LEU88
J	LEU91
J	HIS92
J	LEU96
J	VAL98
J	ASN102
J	LEU106
J	HOH148

site_id	AC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE HEM K 142

Chain	Residue
K	TYR42
K	PHE43
K	HIS45
K	HIS58
K	LYS61
K	LEU66
K	HIS87
K	LEU91
K	ASN97
K	PHE98
K	LEU101

site_id	AC8
Number of Residues	12
Details	BINDING SITE FOR RESIDUE HEM L 147

Chain	Residue
L	HIS92
L	LEU96
L	ASN102
L	LEU106
L	HOH152
L	THR38
L	PHE41
L	PHE42
L	HIS63
L	LYS66
L	VAL67
L	SER70

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	Peptide: {"description":"Hemopressin","featureId":"PRO_0000455849","evidences":[{"source":"UniProtKB","id":"P01946","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00238","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"description":"proximal binding residue","evidences":[{"source":"PROSITE-ProRule","id":"PRU00238","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"description":"distal binding residue"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"description":"proximal binding residue"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	144
Details	Domain: {"description":"Globin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00238","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)