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2RHX

Crystal structure of the 3-MBT repeats from human L3MBTL1 bound to dimethyl-lysine

Functional Information from GO Data
ChainGOidnamespacecontents
A0005634cellular_componentnucleus
A0006355biological_processregulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 A 1
ChainResidue
ASER207
ATRP208
AARG321
ASER508
AHOH558
AHOH820

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 2
ChainResidue
AARG460
AHIS498
AHOH832

site_idAC3
Number of Residues9
DetailsBINDING SITE FOR RESIDUE MLY A 537
ChainResidue
AASP355
ATRP382
ATYR386
AGLU472
ALYS480
AHOH646
AHOH674
AHOH692
AHOH817

site_idAC4
Number of Residues9
DetailsBINDING SITE FOR RESIDUE PG4 A 538
ChainResidue
ACYS278
AASP459
AARG461
AARG461
APHE483
ATRP486
ATYR490
AHOH592
AHOH638

site_idAC5
Number of Residues1
DetailsBINDING SITE FOR RESIDUE PGE A 539
ChainResidue
ALYS509

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Mediates recognition of monomethylated and dimethylated peptides
ChainResidueDetails
ATYR427

site_idSWS_FT_FI2
Number of Residues1
DetailsSITE: Positioned at the entrance of MBT 2 and is required for recognition of monomethylated and dimethylated peptides
ChainResidueDetails
AGLU430

226707

PDB entries from 2024-10-30

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