2RF6

Crystal Structure of the Vaccinia Virus Dual-Specificity Phosphatase VH1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004721	molecular_function	phosphoprotein phosphatase activity
A	0004722	molecular_function	protein serine/threonine phosphatase activity
A	0004725	molecular_function	protein tyrosine phosphatase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0006470	biological_process	protein dephosphorylation
A	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
A	0016311	biological_process	dephosphorylation
A	0016787	molecular_function	hydrolase activity
A	0016791	molecular_function	phosphatase activity
A	0030430	cellular_component	host cell cytoplasm
A	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
A	0039563	biological_process	symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity
A	0044423	cellular_component	virion component
A	0052170	biological_process	symbiont-mediated suppression of host innate immune response

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 177

Chain	Residue
A	ASP84
A	SER115
A	ALA116
A	ALA117
A	GLY118
A	VAL119
A	ASN120
A	ARG121

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	26
Details	Region: {"description":"Dimerization"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Phosphocysteine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1848923","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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