2REX

Crystal structure of the effector domain of PLXNB1 bound with Rnd1 GTPase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0017154	molecular_function	semaphorin receptor activity
A	0071526	biological_process	semaphorin-plexin signaling pathway
B	0003924	molecular_function	GTPase activity
B	0005525	molecular_function	GTP binding
B	0007264	biological_process	small GTPase-mediated signal transduction
C	0017154	molecular_function	semaphorin receptor activity
C	0071526	biological_process	semaphorin-plexin signaling pathway
D	0003924	molecular_function	GTPase activity
D	0005525	molecular_function	GTP binding
D	0007264	biological_process	small GTPase-mediated signal transduction

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG B 550

Chain	Residue
B	THR27
B	THR45
B	GNP500
B	HOH567
B	HOH581

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 551

Chain	Residue
B	HOH566
C	GLU1763
B	TYR38
B	GLU40
B	HOH564
B	HOH565

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG D 550

Chain	Residue
D	THR27
D	THR45
D	GNP500
D	HOH568
D	HOH590

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA D 551

Chain	Residue
A	GLU1763
D	TYR38
D	GLU40
D	HOH582
D	HOH583
D	HOH584

---

site_id	AC5
Number of Residues	27
Details	BINDING SITE FOR RESIDUE GNP B 500

Chain	Residue
B	VAL22
B	GLN23
B	CYS24
B	GLY25
B	LYS26
B	THR27
B	ALA28
B	TYR38
B	PRO39
B	GLU40
B	THR41
B	TYR42
B	THR45
B	THR68
B	SER69
B	GLY70
B	LYS126
B	ASP128
B	LEU129
B	SER168
B	ALA169
B	PHE170
B	MG550
B	UNX557
B	HOH571
B	HOH577
B	HOH581

---

site_id	AC6
Number of Residues	28
Details	BINDING SITE FOR RESIDUE GNP D 500

Chain	Residue
D	VAL22
D	GLN23
D	CYS24
D	GLY25
D	LYS26
D	THR27
D	ALA28
D	TYR38
D	PRO39
D	GLU40
D	THR41
D	TYR42
D	THR45
D	THR68
D	GLY70
D	LYS126
D	ASP128
D	LEU129
D	ALA169
D	PHE170
D	MG550
D	UNX553
D	HOH565
D	HOH568
D	HOH570
D	HOH572
D	HOH580
D	HOH590

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE UNX A 1

Chain	Residue
A	GLY1762
A	GLU1763
A	VAL1811

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE UNX C 2

Chain	Residue
B	ASP36
C	GLY1762
C	GLU1763

---

site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE UNX C 3

Chain	Residue
C	ILE1816

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE UNX B 552

Chain	Residue
B	THR45
B	VAL46

---

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE UNX A 5

Chain	Residue
A	LEU1815
A	ILE1816

---

site_id	BC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE UNX B 553

Chain	Residue
B	ASN49

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE UNX B 554

Chain	Residue
B	MET29
B	GLY124
B	GLY167
B	ILE176
B	ILE179

---

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE UNX C 9

Chain	Residue
C	ILE1777
C	LYS1781
C	HOH1871

---

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE UNX D 553

Chain	Residue
D	GLN23
D	GNP500

---

site_id	BC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE UNX A 11

Chain	Residue
A	LYS1781
A	HOH1867

---

site_id	BC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE UNX B 555

Chain	Residue
B	GLN23

---

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE UNX B 556

Chain	Residue
B	VAL32
B	LEU33
B	ASP36
B	GLU173
B	HIS177

---

site_id	CC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE UNX B 557

Chain	Residue
B	TYR38
B	GNP500
C	GLY1844

---

site_id	CC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE UNX B 558

Chain	Residue
B	TYR74

---

site_id	CC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE UNX B 559

Chain	Residue
B	CYS153

---

site_id	CC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE UNX B 560

Chain	Residue
B	SER134
B	MET137

---

site_id	CC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE UNX B 561

Chain	Residue
B	GLU173
B	LYS174

---

site_id	CC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE UNX D 554

Chain	Residue
D	VAL46

---

site_id	CC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE UNX C 20

Chain	Residue
C	LEU1836
C	VAL1841

---

site_id	CC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE UNX D 556

Chain	Residue
A	GLY1844
D	TYR38

---

site_id	CC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE UNX D 559

Chain	Residue
D	ASN49
D	THR51

---

site_id	DC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE UNX D 560

Chain	Residue
D	ASN49

---

site_id	DC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE UNX C 28

Chain	Residue
C	LYS1770
C	GLN1787

---

site_id	DC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE UNX D 561

Chain	Residue
D	SER148
D	TYR149

---

site_id	DC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE UNX A 30

Chain	Residue
A	ASP1821
A	SER1824

---

Functional Information from PROSITE/UniProt

site_id	PS00213
Number of Residues	13
Details	LIPOCALIN Lipocalin signature. DVTs.EVQGLWRRL

Chain	Residue	Details
A	ASP1821-LEU1833

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Site: {"description":"Important for interaction with RAC1 and RND1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	Motif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	40
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19843518","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2CLS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
B	SER71

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
D	SER71

---