2RD5
Structural basis for the regulation of N-acetylglutamate kinase by PII in Arabidopsis thaliana
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003991 | molecular_function | acetylglutamate kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006526 | biological_process | L-arginine biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| B | 0003991 | molecular_function | acetylglutamate kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006526 | biological_process | L-arginine biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| C | 0006808 | biological_process | regulation of nitrogen utilization |
| C | 0030234 | molecular_function | enzyme regulator activity |
| D | 0006808 | biological_process | regulation of nitrogen utilization |
| D | 0030234 | molecular_function | enzyme regulator activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 2002 |
| Chain | Residue |
| B | ASP196 |
| B | GLY251 |
| B | LYS255 |
| B | ADP2000 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG C 1001 |
| Chain | Residue |
| C | GLY48 |
| C | ATP1000 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG D 1001 |
| Chain | Residue |
| D | GLY48 |
| D | ATP1000 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE ARG A 1000 |
| Chain | Residue |
| A | LYS210 |
| A | LYS232 |
| A | GLU284 |
| A | ILE285 |
| A | SER287 |
| A | GLU289 |
| A | GLY290 |
| A | GLY292 |
| A | MET294 |
| A | PHE33 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ADP A 2000 |
| Chain | Residue |
| A | GLY219 |
| A | LEU221 |
| A | LYS247 |
| A | VAL248 |
| A | ALA249 |
| A | GLY251 |
| A | MET252 |
| A | LYS255 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NLG A 2001 |
| Chain | Residue |
| A | GLY75 |
| A | GLY76 |
| A | ARG98 |
| A | ASN192 |
| A | ALA195 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE ARG B 1000 |
| Chain | Residue |
| B | PHE33 |
| B | LYS210 |
| B | LYS232 |
| B | GLU284 |
| B | ILE285 |
| B | SER287 |
| B | GLU289 |
| B | GLY290 |
| B | GLY292 |
| B | MET294 |
| site_id | AC8 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE ADP B 2000 |
| Chain | Residue |
| A | GLN152 |
| B | LYS41 |
| B | GLY43 |
| B | GLY44 |
| B | ALA45 |
| B | THR215 |
| B | ASP216 |
| B | GLY219 |
| B | LEU221 |
| B | LYS224 |
| B | LYS247 |
| B | ALA249 |
| B | GLY251 |
| B | MET252 |
| B | LYS255 |
| B | MG2002 |
| B | HOH2005 |
| B | HOH2023 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE NLG B 2001 |
| Chain | Residue |
| B | GLY75 |
| B | GLY76 |
| B | GLY77 |
| B | LEU97 |
| B | ARG98 |
| B | ASN192 |
| B | ASN194 |
| B | ALA195 |
| B | HOH2005 |
| site_id | BC1 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE ATP C 1000 |
| Chain | Residue |
| C | ILE18 |
| C | GLY38 |
| C | VAL39 |
| C | THR40 |
| C | GLY46 |
| C | PHE47 |
| C | GLY48 |
| C | GLN50 |
| C | LYS70 |
| C | GLU74 |
| C | VAL76 |
| C | ILE98 |
| C | GLY99 |
| C | GLY101 |
| C | LYS102 |
| C | PHE104 |
| C | ARG113 |
| C | ARG115 |
| C | MET126 |
| C | MG1001 |
| C | HOH1005 |
| site_id | BC2 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE ATP D 1000 |
| Chain | Residue |
| D | VAL76 |
| D | ILE98 |
| D | GLY99 |
| D | GLY101 |
| D | LYS102 |
| D | ARG113 |
| D | ARG115 |
| D | MET126 |
| D | MG1001 |
| D | HOH1009 |
| D | HOH1012 |
| D | ILE18 |
| D | GLY38 |
| D | VAL39 |
| D | THR40 |
| D | GLY46 |
| D | PHE47 |
| D | GLY48 |
| D | GLN50 |
| D | LYS70 |
| D | GLU74 |
Functional Information from PROSITE/UniProt
| site_id | PS00638 |
| Number of Residues | 14 |
| Details | PII_GLNB_CTER P-II protein C-terminal region signature. TgeiGDGKIFVlpV |
| Chain | Residue | Details |
| C | THR95-VAL108 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25416954","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4USJ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 22 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17913711","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25416954","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2RD5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4USJ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17913711","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2RD5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 14 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17913711","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1oh9 |
| Chain | Residue | Details |
| A | GLY44 | |
| A | LYS255 | |
| A | GLY77 | |
| A | LYS41 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1oh9 |
| Chain | Residue | Details |
| B | GLY44 | |
| B | LYS255 | |
| B | GLY77 | |
| B | LYS41 |
