2RCJ

Solution structure of human Immunoglobulin M

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0001788	biological_process	antibody-dependent cellular cytotoxicity
C	0002250	biological_process	adaptive immune response
C	0002376	biological_process	immune system process
C	0003823	molecular_function	antigen binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005886	cellular_component	plasma membrane
C	0016020	cellular_component	membrane
C	0019814	cellular_component	immunoglobulin complex
C	0034988	molecular_function	Fc-gamma receptor I complex binding
C	0050853	biological_process	B cell receptor signaling pathway
C	0070062	cellular_component	extracellular exosome
C	0071735	cellular_component	IgG immunoglobulin complex
C	0072562	cellular_component	blood microparticle
C	0097278	biological_process	complement-dependent cytotoxicity
D	0001788	biological_process	antibody-dependent cellular cytotoxicity
D	0002250	biological_process	adaptive immune response
D	0002376	biological_process	immune system process
D	0003823	molecular_function	antigen binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005886	cellular_component	plasma membrane
D	0016020	cellular_component	membrane
D	0019814	cellular_component	immunoglobulin complex
D	0034988	molecular_function	Fc-gamma receptor I complex binding
D	0050853	biological_process	B cell receptor signaling pathway
D	0070062	cellular_component	extracellular exosome
D	0071735	cellular_component	IgG immunoglobulin complex
D	0072562	cellular_component	blood microparticle
D	0097278	biological_process	complement-dependent cytotoxicity
G	0001788	biological_process	antibody-dependent cellular cytotoxicity
G	0002250	biological_process	adaptive immune response
G	0002376	biological_process	immune system process
G	0003823	molecular_function	antigen binding
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005886	cellular_component	plasma membrane
G	0016020	cellular_component	membrane
G	0019814	cellular_component	immunoglobulin complex
G	0034988	molecular_function	Fc-gamma receptor I complex binding
G	0050853	biological_process	B cell receptor signaling pathway
G	0070062	cellular_component	extracellular exosome
G	0071735	cellular_component	IgG immunoglobulin complex
G	0072562	cellular_component	blood microparticle
G	0097278	biological_process	complement-dependent cytotoxicity
H	0001788	biological_process	antibody-dependent cellular cytotoxicity
H	0002250	biological_process	adaptive immune response
H	0002376	biological_process	immune system process
H	0003823	molecular_function	antigen binding
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005886	cellular_component	plasma membrane
H	0016020	cellular_component	membrane
H	0019814	cellular_component	immunoglobulin complex
H	0034988	molecular_function	Fc-gamma receptor I complex binding
H	0050853	biological_process	B cell receptor signaling pathway
H	0070062	cellular_component	extracellular exosome
H	0071735	cellular_component	IgG immunoglobulin complex
H	0072562	cellular_component	blood microparticle
H	0097278	biological_process	complement-dependent cytotoxicity
K	0001788	biological_process	antibody-dependent cellular cytotoxicity
K	0002250	biological_process	adaptive immune response
K	0002376	biological_process	immune system process
K	0003823	molecular_function	antigen binding
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005615	cellular_component	extracellular space
K	0005886	cellular_component	plasma membrane
K	0016020	cellular_component	membrane
K	0019814	cellular_component	immunoglobulin complex
K	0034988	molecular_function	Fc-gamma receptor I complex binding
K	0050853	biological_process	B cell receptor signaling pathway
K	0070062	cellular_component	extracellular exosome
K	0071735	cellular_component	IgG immunoglobulin complex
K	0072562	cellular_component	blood microparticle
K	0097278	biological_process	complement-dependent cytotoxicity
L	0001788	biological_process	antibody-dependent cellular cytotoxicity
L	0002250	biological_process	adaptive immune response
L	0002376	biological_process	immune system process
L	0003823	molecular_function	antigen binding
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0005886	cellular_component	plasma membrane
L	0016020	cellular_component	membrane
L	0019814	cellular_component	immunoglobulin complex
L	0034988	molecular_function	Fc-gamma receptor I complex binding
L	0050853	biological_process	B cell receptor signaling pathway
L	0070062	cellular_component	extracellular exosome
L	0071735	cellular_component	IgG immunoglobulin complex
L	0072562	cellular_component	blood microparticle
L	0097278	biological_process	complement-dependent cytotoxicity
O	0001788	biological_process	antibody-dependent cellular cytotoxicity
O	0002250	biological_process	adaptive immune response
O	0002376	biological_process	immune system process
O	0003823	molecular_function	antigen binding
O	0005515	molecular_function	protein binding
O	0005576	cellular_component	extracellular region
O	0005615	cellular_component	extracellular space
O	0005886	cellular_component	plasma membrane
O	0016020	cellular_component	membrane
O	0019814	cellular_component	immunoglobulin complex
O	0034988	molecular_function	Fc-gamma receptor I complex binding
O	0050853	biological_process	B cell receptor signaling pathway
O	0070062	cellular_component	extracellular exosome
O	0071735	cellular_component	IgG immunoglobulin complex
O	0072562	cellular_component	blood microparticle
O	0097278	biological_process	complement-dependent cytotoxicity
P	0001788	biological_process	antibody-dependent cellular cytotoxicity
P	0002250	biological_process	adaptive immune response
P	0002376	biological_process	immune system process
P	0003823	molecular_function	antigen binding
P	0005515	molecular_function	protein binding
P	0005576	cellular_component	extracellular region
P	0005615	cellular_component	extracellular space
P	0005886	cellular_component	plasma membrane
P	0016020	cellular_component	membrane
P	0019814	cellular_component	immunoglobulin complex
P	0034988	molecular_function	Fc-gamma receptor I complex binding
P	0050853	biological_process	B cell receptor signaling pathway
P	0070062	cellular_component	extracellular exosome
P	0071735	cellular_component	IgG immunoglobulin complex
P	0072562	cellular_component	blood microparticle
P	0097278	biological_process	complement-dependent cytotoxicity
S	0001788	biological_process	antibody-dependent cellular cytotoxicity
S	0002250	biological_process	adaptive immune response
S	0002376	biological_process	immune system process
S	0003823	molecular_function	antigen binding
S	0005515	molecular_function	protein binding
S	0005576	cellular_component	extracellular region
S	0005615	cellular_component	extracellular space
S	0005886	cellular_component	plasma membrane
S	0016020	cellular_component	membrane
S	0019814	cellular_component	immunoglobulin complex
S	0034988	molecular_function	Fc-gamma receptor I complex binding
S	0050853	biological_process	B cell receptor signaling pathway
S	0070062	cellular_component	extracellular exosome
S	0071735	cellular_component	IgG immunoglobulin complex
S	0072562	cellular_component	blood microparticle
S	0097278	biological_process	complement-dependent cytotoxicity
T	0001788	biological_process	antibody-dependent cellular cytotoxicity
T	0002250	biological_process	adaptive immune response
T	0002376	biological_process	immune system process
T	0003823	molecular_function	antigen binding
T	0005515	molecular_function	protein binding
T	0005576	cellular_component	extracellular region
T	0005615	cellular_component	extracellular space
T	0005886	cellular_component	plasma membrane
T	0016020	cellular_component	membrane
T	0019814	cellular_component	immunoglobulin complex
T	0034988	molecular_function	Fc-gamma receptor I complex binding
T	0050853	biological_process	B cell receptor signaling pathway
T	0070062	cellular_component	extracellular exosome
T	0071735	cellular_component	IgG immunoglobulin complex
T	0072562	cellular_component	blood microparticle
T	0097278	biological_process	complement-dependent cytotoxicity

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH

Chain	Residue	Details
C	TYR193-HIS199
C	TYR295-HIS301
C	PHE503-HIS509
A	TYR199-HIS205
U	TYR82-HIS88

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:11406581, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19358553, ECO:0000269|PubMed:20357243

Chain	Residue	Details
C	LEU394
T	LEU394
D	LEU394
G	LEU394
H	LEU394
K	LEU394
L	LEU394
O	LEU394
P	LEU394
S	LEU394

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