2RCJ
Solution structure of human Immunoglobulin M
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002250 | biological_process | adaptive immune response |
| A | 0002376 | biological_process | immune system process |
| A | 0003823 | molecular_function | antigen binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006955 | biological_process | immune response |
| A | 0016064 | biological_process | immunoglobulin mediated immune response |
| A | 0019814 | cellular_component | immunoglobulin complex |
| B | 0002250 | biological_process | adaptive immune response |
| B | 0002376 | biological_process | immune system process |
| B | 0003823 | molecular_function | antigen binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006955 | biological_process | immune response |
| B | 0016064 | biological_process | immunoglobulin mediated immune response |
| B | 0019814 | cellular_component | immunoglobulin complex |
| E | 0002250 | biological_process | adaptive immune response |
| E | 0002376 | biological_process | immune system process |
| E | 0003823 | molecular_function | antigen binding |
| E | 0005576 | cellular_component | extracellular region |
| E | 0005886 | cellular_component | plasma membrane |
| E | 0006955 | biological_process | immune response |
| E | 0016064 | biological_process | immunoglobulin mediated immune response |
| E | 0019814 | cellular_component | immunoglobulin complex |
| F | 0002250 | biological_process | adaptive immune response |
| F | 0002376 | biological_process | immune system process |
| F | 0003823 | molecular_function | antigen binding |
| F | 0005576 | cellular_component | extracellular region |
| F | 0005886 | cellular_component | plasma membrane |
| F | 0006955 | biological_process | immune response |
| F | 0016064 | biological_process | immunoglobulin mediated immune response |
| F | 0019814 | cellular_component | immunoglobulin complex |
| I | 0002250 | biological_process | adaptive immune response |
| I | 0002376 | biological_process | immune system process |
| I | 0003823 | molecular_function | antigen binding |
| I | 0005576 | cellular_component | extracellular region |
| I | 0005886 | cellular_component | plasma membrane |
| I | 0006955 | biological_process | immune response |
| I | 0016064 | biological_process | immunoglobulin mediated immune response |
| I | 0019814 | cellular_component | immunoglobulin complex |
| J | 0002250 | biological_process | adaptive immune response |
| J | 0002376 | biological_process | immune system process |
| J | 0003823 | molecular_function | antigen binding |
| J | 0005576 | cellular_component | extracellular region |
| J | 0005886 | cellular_component | plasma membrane |
| J | 0006955 | biological_process | immune response |
| J | 0016064 | biological_process | immunoglobulin mediated immune response |
| J | 0019814 | cellular_component | immunoglobulin complex |
| M | 0002250 | biological_process | adaptive immune response |
| M | 0002376 | biological_process | immune system process |
| M | 0003823 | molecular_function | antigen binding |
| M | 0005576 | cellular_component | extracellular region |
| M | 0005886 | cellular_component | plasma membrane |
| M | 0006955 | biological_process | immune response |
| M | 0016064 | biological_process | immunoglobulin mediated immune response |
| M | 0019814 | cellular_component | immunoglobulin complex |
| N | 0002250 | biological_process | adaptive immune response |
| N | 0002376 | biological_process | immune system process |
| N | 0003823 | molecular_function | antigen binding |
| N | 0005576 | cellular_component | extracellular region |
| N | 0005886 | cellular_component | plasma membrane |
| N | 0006955 | biological_process | immune response |
| N | 0016064 | biological_process | immunoglobulin mediated immune response |
| N | 0019814 | cellular_component | immunoglobulin complex |
| Q | 0002250 | biological_process | adaptive immune response |
| Q | 0002376 | biological_process | immune system process |
| Q | 0003823 | molecular_function | antigen binding |
| Q | 0005576 | cellular_component | extracellular region |
| Q | 0005886 | cellular_component | plasma membrane |
| Q | 0006955 | biological_process | immune response |
| Q | 0016064 | biological_process | immunoglobulin mediated immune response |
| Q | 0019814 | cellular_component | immunoglobulin complex |
| R | 0002250 | biological_process | adaptive immune response |
| R | 0002376 | biological_process | immune system process |
| R | 0003823 | molecular_function | antigen binding |
| R | 0005576 | cellular_component | extracellular region |
| R | 0005886 | cellular_component | plasma membrane |
| R | 0006955 | biological_process | immune response |
| R | 0016064 | biological_process | immunoglobulin mediated immune response |
| R | 0019814 | cellular_component | immunoglobulin complex |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH |
| Chain | Residue | Details |
| A | TYR199-HIS205 | |
| U | TYR82-HIS88 | |
| C | TYR193-HIS199 | |
| C | TYR295-HIS301 | |
| C | PHE503-HIS509 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 970 |
| Details | Domain: {"description":"Ig-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 240 |
| Details | Region: {"description":"Framework-1","evidences":[{"source":"UniProtKB","id":"P23083","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 70 |
| Details | Region: {"description":"Complementarity-determining-1","evidences":[{"source":"UniProtKB","id":"P23083","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 160 |
| Details | Region: {"description":"Framework-2","evidences":[{"source":"UniProtKB","id":"P23083","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 70 |
| Details | Region: {"description":"Complementarity-determining-2","evidences":[{"source":"UniProtKB","id":"P23083","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 370 |
| Details | Region: {"description":"Framework-3","evidences":[{"source":"UniProtKB","id":"P23083","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 10 |
| Details | Region: {"description":"Complementarity-determining-3","evidences":[{"source":"UniProtKB","id":"P23083","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 10 |
| Details | Modified residue: {"description":"Pyrrolidone carboxylic acid","evidences":[{"source":"PubMed","id":"420800","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6884994","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 930 |
| Details | Domain: {"description":"Ig-like 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 990 |
| Details | Domain: {"description":"Ig-like 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 960 |
| Details | Domain: {"description":"Ig-like 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 970 |
| Details | Region: {"description":"CH1","evidences":[{"source":"PubMed","id":"15572068","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 200 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 10 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"11406581","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19358553","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20357243","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
