2RCB

Crystal structure of the NR3B ligand binding core complex with D-serine at 1.62 Angstrom resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE DSN A 901

Chain	Residue
A	TYR95
A	TYR250
A	SER121
A	SER123
A	ARG128
A	SER177
A	SER178
A	ALA179
A	MET221
A	ASP222

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE DSN B 902

Chain	Residue
B	TYR95
B	SER121
B	SER123
B	ARG128
B	SER177
B	SER178
B	ALA179
B	MET221
B	ASP222
B	TYR250

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 902

Chain	Residue
A	GLY113
A	HIS116
A	HOH1089

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	76
Details	TRANSMEM: Helical => ECO:0000250|UniProtKB:Q13224

Chain	Residue	Details
A	PRO165-LYS184
A	ILE232-GLY251
B	PRO165-LYS184
B	ILE232-GLY251

---

site_id	SWS_FT_FI2
Number of Residues	66
Details	TOPO_DOM: Cytoplasmic => ECO:0000305

Chain	Residue	Details
A	ALA185-GLY205
A	ALA218-SER231
B	ALA185-GLY205
B	ALA218-SER231

---

site_id	SWS_FT_FI3
Number of Residues	22
Details	INTRAMEM: Discontinuously helical => ECO:0000250|UniProtKB:Q13224

Chain	Residue	Details
A	VAL206-ASN217
B	VAL206-ASN217

---

site_id	SWS_FT_FI4
Number of Residues	10
Details	BINDING: BINDING => ECO:0000269|PubMed:18636091, ECO:0007744|PDB:2RCA

Chain	Residue	Details
A	SER121
B	ASP222
A	SER123
A	ARG128
A	SER178
A	ASP222
B	SER121
B	SER123
B	ARG128
B	SER178

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:18636091, ECO:0007744|PDB:2RCB

Chain	Residue	Details
A	ALA179
B	ALA179

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN41
A	ASN55
A	ASN263
B	ASN41
B	ASN55
B	ASN263

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