2RAY

beta-chlorophenetole in complex with T4 lysozyme L99A

Functional Information from GO Data

Chain	GOid	namespace	contents
X	0003796	molecular_function	lysozyme activity
X	0003824	molecular_function	catalytic activity
X	0008152	biological_process	metabolic process
X	0009253	biological_process	peptidoglycan catabolic process
X	0016787	molecular_function	hydrolase activity
X	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
X	0016998	biological_process	cell wall macromolecule catabolic process
X	0030430	cellular_component	host cell cytoplasm
X	0031640	biological_process	killing of cells of another organism
X	0042742	biological_process	defense response to bacterium
X	0044659	biological_process	viral release from host cell by cytolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 X 1001

Chain	Residue
X	ARG14
X	LYS19
X	ARG125
X	TRP126
X	ASP127
X	GLU128
X	HOH2046
X	HOH2149
X	HOH2163

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site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 258 X 2001

Chain	Residue
X	TYR88
X	ALA99
X	MET102
X	SER117
X	LEU118
X	LEU121
X	LEU133
X	PHE153

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098

Chain	Residue	Details
X	GLU11

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:1892846, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098

Chain	Residue	Details
X	ASP20

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:8266098

Chain	Residue	Details
X	LEU32
X	PHE104

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site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000303|PubMed:7831309

Chain	Residue	Details
X	SER117
X	ASN132

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	2
Details	M-CSA 921

Chain	Residue	Details
X	GLU11	proton shuttle (general acid/base)
X	ASP20	covalent catalysis

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