2RAN
RAT ANNEXIN V CRYSTAL STRUCTURE: CA2+-INDUCED CONFORMATIONAL CHANGES
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001786 | molecular_function | phosphatidylserine binding |
| A | 0005388 | molecular_function | P-type calcium transporter activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005543 | molecular_function | phospholipid binding |
| A | 0005544 | molecular_function | calcium-dependent phospholipid binding |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0007596 | biological_process | blood coagulation |
| A | 0008021 | cellular_component | synaptic vesicle |
| A | 0009897 | cellular_component | external side of plasma membrane |
| A | 0012506 | cellular_component | vesicle membrane |
| A | 0014704 | cellular_component | intercalated disc |
| A | 0017046 | molecular_function | peptide hormone binding |
| A | 0030018 | cellular_component | Z disc |
| A | 0030195 | biological_process | negative regulation of blood coagulation |
| A | 0030425 | cellular_component | dendrite |
| A | 0030672 | cellular_component | synaptic vesicle membrane |
| A | 0030971 | molecular_function | receptor tyrosine kinase binding |
| A | 0042383 | cellular_component | sarcolemma |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042995 | cellular_component | cell projection |
| A | 0043025 | cellular_component | neuronal cell body |
| A | 0043065 | biological_process | positive regulation of apoptotic process |
| A | 0043204 | cellular_component | perikaryon |
| A | 0043679 | cellular_component | axon terminus |
| A | 0050819 | biological_process | negative regulation of coagulation |
| A | 0051592 | biological_process | response to calcium ion |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| A | 0071284 | biological_process | cellular response to lead ion |
| A | 0072563 | cellular_component | endothelial microparticle |
| A | 0097066 | biological_process | response to thyroid hormone |
| A | 0097211 | biological_process | cellular response to gonadotropin-releasing hormone |
| A | 1901317 | biological_process | regulation of flagellated sperm motility |
| A | 1902721 | biological_process | negative regulation of prolactin secretion |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 320 |
| Chain | Residue |
| A | MET26 |
| A | GLY28 |
| A | GLY30 |
| A | GLU70 |
| A | HOH404 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 321 |
| Chain | Residue |
| A | LYS68 |
| A | LEU71 |
| A | GLU76 |
| A | HOH499 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA A 322 |
| Chain | Residue |
| A | LEU98 |
| A | GLY100 |
| A | ALA101 |
| A | GLY102 |
| A | THR103 |
| A | ASP142 |
| A | HOH408 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 323 |
| Chain | Residue |
| A | VAL140 |
| A | THR143 |
| A | GLN148 |
| A | HOH409 |
| A | HOH410 |
| A | HOH411 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 324 |
| Chain | Residue |
| A | GLY181 |
| A | LYS184 |
| A | GLY186 |
| A | GLU226 |
| A | HOH412 |
| A | HOH414 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 325 |
| Chain | Residue |
| A | ASP224 |
| A | THR227 |
| A | GLU232 |
| A | HOH418 |
| A | HOH503 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 326 |
| Chain | Residue |
| A | MET257 |
| A | LYS258 |
| A | ALA260 |
| A | GLY261 |
| A | ASP301 |
| A | HOH419 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 327 |
| Chain | Residue |
| A | ARG23 |
| A | LYS27 |
| A | GLY28 |
| A | ARG61 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 328 |
| Chain | Residue |
| A | ARG283 |
| A | SER293 |
| A | GLY316 |
| A | GLU317 |
Functional Information from PROSITE/UniProt
| site_id | PS00223 |
| Number of Residues | 53 |
| Details | ANNEXIN_1 Annexin repeat signature. GTdedsilnlLtaRsnaQrqQiaeeFktlfgrdLvndMkseltGkfeklIvaL |
| Chain | Residue | Details |
| A | GLY30-LEU82 | |
| A | GLY102-LEU154 | |
| A | GLY186-VAL238 | |
| A | GLY261-LEU313 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0000269|PubMed:7583670 |
| Chain | Residue | Details |
| A | LEU3 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903 |
| Chain | Residue | Details |
| A | ILE36 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 5 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P08758 |
| Chain | Residue | Details |
| A | SER69 | |
| A | PHE75 | |
| A | LEU78 | |
| A | HIS96 | |
| A | GLY100 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P48036 |
| Chain | Residue | Details |
| A | ASN289 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0000250|UniProtKB:P08758 |
| Chain | Residue | Details |
| A | GLY28 |
