Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004707 | molecular_function | MAP kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004707 | molecular_function | MAP kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE 255 B 501 |
| Chain | Residue |
| A | ASN66 |
| B | LEU148 |
| B | MET149 |
| B | ASP150 |
| B | ALA151 |
| B | ASN152 |
| B | GLN155 |
| B | VAL196 |
| B | LEU206 |
| B | TFA602 |
| A | LYS68 |
| A | 255502 |
| B | LYS68 |
| B | ILE70 |
| B | GLY71 |
| B | ASN89 |
| B | ALA91 |
| B | GLU147 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE 255 A 502 |
| Chain | Residue |
| A | LYS68 |
| A | ILE70 |
| A | GLY71 |
| A | VAL78 |
| A | ALA80 |
| A | ASN89 |
| A | ALA91 |
| A | MET146 |
| A | GLU147 |
| A | LEU148 |
| A | MET149 |
| A | ASP150 |
| A | ASN152 |
| A | GLN155 |
| A | VAL196 |
| A | LEU206 |
| A | TFA601 |
| B | ASN66 |
| B | LYS68 |
| B | 255501 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNX A 801 |
| Chain | Residue |
| A | UNX802 |
| A | UNX826 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE UNX A 802 |
| Chain | Residue |
| A | HIS179 |
| A | SER182 |
| A | UNX801 |
| A | UNX807 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNX A 803 |
| Chain | Residue |
| A | UNX805 |
| A | UNX806 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE UNX A 804 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNX A 805 |
| Chain | Residue |
| A | UNX803 |
| A | UNX804 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNX A 806 |
| Chain | Residue |
| A | UNX803 |
| A | UNX807 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNX A 807 |
| Chain | Residue |
| A | UNX802 |
| A | UNX806 |
| site_id | BC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE UNX A 808 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE UNX A 809 |
| Chain | Residue |
| A | LYS106 |
| A | ALA211 |
| A | UNX810 |
| site_id | BC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE UNX A 810 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE UNX B 811 |
| Chain | Residue |
| B | UNX812 |
| B | UNX817 |
| B | UNX825 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE UNX B 812 |
| Chain | Residue |
| B | HIS179 |
| B | UNX811 |
| B | UNX817 |
| B | UNX825 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE UNX B 813 |
| Chain | Residue |
| A | UNX814 |
| B | UNX815 |
| B | UNX816 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE UNX A 814 |
| Chain | Residue |
| B | UNX813 |
| B | UNX815 |
| B | UNX816 |
| site_id | BC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE UNX B 815 |
| Chain | Residue |
| A | UNX814 |
| B | UNX813 |
| B | UNX816 |
| site_id | BC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE UNX B 816 |
| Chain | Residue |
| A | UNX814 |
| B | UNX813 |
| B | UNX815 |
| B | UNX817 |
| site_id | CC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE UNX B 817 |
| Chain | Residue |
| B | UNX811 |
| B | UNX812 |
| B | UNX816 |
| B | UNX825 |
| site_id | CC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE UNX B 819 |
| Chain | Residue |
| B | ARG188 |
| B | LEU210 |
| B | ALA211 |
| site_id | CC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE UNX A 821 |
| site_id | CC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE UNX A 822 |
| Chain | Residue |
| A | ILE235 |
| A | TYR268 |
| A | UNX821 |
| A | UNX823 |
| site_id | CC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE UNX A 823 |
| Chain | Residue |
| A | TYR268 |
| A | UNX822 |
| A | UNX824 |
| site_id | CC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE UNX A 824 |
| site_id | CC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE UNX B 825 |
| Chain | Residue |
| B | UNX811 |
| B | UNX812 |
| B | UNX817 |
| site_id | CC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE UNX A 826 |
| site_id | CC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE UNX B 828 |
| site_id | DC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE TFA A 601 |
| Chain | Residue |
| A | ILE70 |
| A | GLY71 |
| A | SER72 |
| A | ASN152 |
| A | SER193 |
| A | LEU206 |
| A | 255502 |
| site_id | DC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE TFA B 602 |
| Chain | Residue |
| B | ILE70 |
| B | GLY71 |
| B | SER72 |
| B | ASN152 |
| B | SER193 |
| B | LEU206 |
| B | 255501 |
| site_id | DC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A 701 |
| Chain | Residue |
| A | GLY239 |
| A | TYR240 |
| site_id | DC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 702 |
| Chain | Residue |
| A | GLN102 |
| A | VAL361 |
| A | ILE387 |
| A | HOH896 |
| site_id | DC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 703 |
| Chain | Residue |
| B | GLN102 |
| B | VAL361 |
| B | ILE387 |
| B | HOH863 |
| site_id | DC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO B 704 |
| Chain | Residue |
| B | ALA345 |
| B | ARG347 |
| site_id | DC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 705 |
| Chain | Residue |
| A | SER330 |
| A | ARG333 |
| A | ASP334 |
| B | ASP334 |
| site_id | DC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 707 |
| Chain | Residue |
| A | ARG258 |
| A | GLN278 |
| A | LYS311 |
Functional Information from PROSITE/UniProt
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKpsNIVV |
| Chain | Residue | Details |
| A | ILE185-VAL197 | |
| site_id | PS01351 |
| Number of Residues | 103 |
| Details | MAPK MAP kinase signature. FqnqthakrayRElvlmkcvnhkniisllnvftpqktleefqdvylvmelmdanlcqviqmeldhermsyllyqmlcgikhlhsagiih..........RDlKpsnivvksdC |
| Chain | Residue | Details |
| A | PHE99-OCY201 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Motif: {"description":"TXY"} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor"} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 18 |
| Details | Binding site: {} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine; by MAP2K7","evidences":[{"source":"PubMed","id":"10715136","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine; by MAP2K4","evidences":[{"source":"PubMed","id":"10715136","evidenceCode":"ECO:0000269"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | ASP189 | |
| A | SER193 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| B | ASP189 | |
| B | SER193 | |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | ASP189 | |
| A | LYS191 | |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| B | ASP189 | |
| B | LYS191 | |
| site_id | CSA5 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | ASP189 | |
| A | LYS191 | |
| A | ASN194 | |
| site_id | CSA6 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| B | ASP189 | |
| B | LYS191 | |
| B | ASN194 | |
