2R9E
The structure of the binary complex of citryl dethia COA and citrate synthase from the thermophilic archaeonthermoplasma acidophilum
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006099 | biological_process | tricarboxylic acid cycle |
| A | 0016740 | molecular_function | transferase activity |
| A | 0036440 | molecular_function | citrate synthase activity |
| A | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006099 | biological_process | tricarboxylic acid cycle |
| B | 0016740 | molecular_function | transferase activity |
| B | 0036440 | molecular_function | citrate synthase activity |
| B | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0006099 | biological_process | tricarboxylic acid cycle |
| C | 0016740 | molecular_function | transferase activity |
| C | 0036440 | molecular_function | citrate synthase activity |
| C | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005975 | biological_process | carbohydrate metabolic process |
| D | 0006099 | biological_process | tricarboxylic acid cycle |
| D | 0016740 | molecular_function | transferase activity |
| D | 0036440 | molecular_function | citrate synthase activity |
| D | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE SDX A 700 |
| Chain | Residue |
| A | HIS187 |
| A | PHE260 |
| A | GLY261 |
| A | HIS262 |
| A | ARG263 |
| A | ARG271 |
| A | ILE312 |
| A | ASN315 |
| A | ASP317 |
| A | ARG344 |
| A | HOH1056 |
| A | PRO190 |
| A | HOH1595 |
| A | HOH1606 |
| A | HOH1750 |
| A | HOH2269 |
| A | HOH2323 |
| A | HOH2324 |
| A | HOH2325 |
| A | HOH2326 |
| B | ARG361 |
| B | ARG364 |
| A | LEU221 |
| A | HIS222 |
| A | ALA225 |
| A | ARG256 |
| A | LEU257 |
| A | MET258 |
| A | GLY259 |
| site_id | AC2 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE SDX B 701 |
| Chain | Residue |
| A | ARG361 |
| A | ARG364 |
| A | HOH2322 |
| B | HIS187 |
| B | PRO190 |
| B | LEU221 |
| B | HIS222 |
| B | ALA225 |
| B | ARG256 |
| B | LEU257 |
| B | GLY259 |
| B | PHE260 |
| B | GLY261 |
| B | HIS262 |
| B | ARG263 |
| B | ARG271 |
| B | ILE312 |
| B | ASN315 |
| B | ARG344 |
| B | HOH1052 |
| B | HOH1150 |
| B | HOH1459 |
| B | HOH1483 |
| B | HOH1611 |
| B | HOH2036 |
| B | HOH2059 |
| B | HOH2265 |
| B | HOH2319 |
| B | HOH2320 |
| B | HOH2321 |
| site_id | AC3 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE SDX C 702 |
| Chain | Residue |
| C | HIS187 |
| C | PRO190 |
| C | LEU221 |
| C | HIS222 |
| C | ALA225 |
| C | ARG256 |
| C | LEU257 |
| C | GLY259 |
| C | PHE260 |
| C | GLY261 |
| C | HIS262 |
| C | ARG263 |
| C | ARG271 |
| C | ILE312 |
| C | ASN315 |
| C | ASP317 |
| C | ARG344 |
| C | HOH1040 |
| C | HOH1074 |
| C | HOH1098 |
| C | HOH1214 |
| C | HOH2294 |
| C | HOH2317 |
| C | HOH2318 |
| D | ARG361 |
| D | ARG364 |
| site_id | AC4 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE SDX D 703 |
| Chain | Residue |
| D | HIS262 |
| D | ARG263 |
| D | ARG271 |
| D | LYS310 |
| D | ILE312 |
| D | ASN315 |
| D | ASP317 |
| D | ARG344 |
| D | HOH1054 |
| D | HOH1133 |
| D | HOH1598 |
| D | HOH2327 |
| D | HOH2328 |
| D | HOH2329 |
| D | HOH2330 |
| B | GLU148 |
| B | LYS151 |
| C | ARG361 |
| C | ARG364 |
| D | HIS187 |
| D | PRO190 |
| D | LEU221 |
| D | HIS222 |
| D | ALA225 |
| D | ARG256 |
| D | LEU257 |
| D | GLY259 |
| D | PHE260 |
| D | GLY261 |
Functional Information from PROSITE/UniProt
| site_id | PS00480 |
| Number of Residues | 13 |
| Details | CITRATE_SYNTHASE Citrate synthase signature. GFGHrVy.KtyDPR |
| Chain | Residue | Details |
| A | GLY259-ARG271 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"7704526","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1aj8 |
| Chain | Residue | Details |
| A | ASP317 | |
| A | HIS262 | |
| A | HIS222 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1aj8 |
| Chain | Residue | Details |
| B | ASP317 | |
| B | HIS262 | |
| B | HIS222 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1aj8 |
| Chain | Residue | Details |
| C | ASP317 | |
| C | HIS262 | |
| C | HIS222 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1aj8 |
| Chain | Residue | Details |
| D | ASP317 | |
| D | HIS262 | |
| D | HIS222 |
| site_id | CSA5 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1aj8 |
| Chain | Residue | Details |
| A | SER192 | |
| A | HIS262 | |
| A | ASP317 | |
| A | HIS222 |
| site_id | CSA6 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1aj8 |
| Chain | Residue | Details |
| B | SER192 | |
| B | HIS262 | |
| B | ASP317 | |
| B | HIS222 |
| site_id | CSA7 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1aj8 |
| Chain | Residue | Details |
| C | SER192 | |
| C | HIS262 | |
| C | ASP317 | |
| C | HIS222 |
| site_id | CSA8 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1aj8 |
| Chain | Residue | Details |
| D | SER192 | |
| D | HIS262 | |
| D | ASP317 | |
| D | HIS222 |
