Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004198 | molecular_function | calcium-dependent cysteine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 365 |
| Chain | Residue |
| A | GLY101 |
| A | ASP106 |
| A | GLU185 |
| A | HOH377 |
| A | HOH434 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 366 |
| Chain | Residue |
| A | GLU333 |
| A | HOH415 |
| A | GLU302 |
| A | ASP309 |
| A | MET329 |
| A | ASP331 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 3 |
| Chain | Residue |
| A | GLN40 |
| A | LYS84 |
| A | HOH408 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 4 |
| Chain | Residue |
| A | ILE35 |
| A | LYS36 |
| A | SER65 |
| A | HOH468 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 5 |
| Chain | Residue |
| A | GLN96 |
| A | PHE97 |
| A | SER140 |
| A | PHE141 |
| A | GLN142 |
| site_id | AC6 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE GRD A 1 |
| Chain | Residue |
| A | GLN109 |
| A | GLY110 |
| A | LEU112 |
| A | GLY113 |
| A | ASP114 |
| A | CYS115 |
| A | TRP116 |
| A | GLY207 |
| A | GLY208 |
| A | THR210 |
| A | GLY271 |
| A | HIS272 |
| A | GLN287 |
| A | TRP298 |
| A | GLU300 |
| A | HOH432 |
| A | HOH459 |
| A | HOH487 |
| A | HOH517 |
| A | HOH665 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 367 |
| Chain | Residue |
| A | LEU91 |
| A | GLY173 |
| A | LYS174 |
| A | GLU215 |
| A | GLY220 |
| A | THR222 |
| A | HOH407 |
| A | HOH422 |
| A | HOH550 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 2 |
| Chain | Residue |
| A | TYR37 |
| A | LEU38 |
| A | ALA60 |
| A | ARG87 |
| A | GLU90 |
| A | HOH463 |
| A | HOH604 |
Functional Information from PROSITE/UniProt
| site_id | PS00139 |
| Number of Residues | 12 |
| Details | THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGaLGDCWLlAA |
| Chain | Residue | Details |
| A | GLN109-ALA120 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 299 |
| Details | Domain: {"description":"Calpain catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00239","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P07384","evidenceCode":"ECO:0000250"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1kfu |
| Chain | Residue | Details |
| A | HIS272 | |
| A | GLN109 | |
| A | ASN296 | |
| A | CYS115 | |
| site_id | CSA2 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1kfu |
| Chain | Residue | Details |
| A | HIS272 | |
| A | GLN109 | |
| A | TRP298 | |
| A | ASN296 | |
| A | CYS115 | |
