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2R8G

Selectivity of Nucleoside Triphosphate Incorporation Opposite 1,N2-Propanodeoxyguanosine (PdG) by the Sulfolobus solfataricus DNA Polymerase Dpo4 Polymerase

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0003677molecular_functionDNA binding
A0003684molecular_functiondamaged DNA binding
A0003887molecular_functionDNA-directed DNA polymerase activity
A0005737cellular_componentcytoplasm
A0006260biological_processDNA replication
A0006261biological_processDNA-templated DNA replication
A0006281biological_processDNA repair
A0006974biological_processDNA damage response
A0016740molecular_functiontransferase activity
A0016779molecular_functionnucleotidyltransferase activity
A0034061molecular_functionDNA polymerase activity
A0042276biological_processerror-prone translesion synthesis
A0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 8001
ChainResidue
AALA181
AILE186
AHOH9083
AHOH9208
PDT513
PHOH9610

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CA A 8002
ChainResidue
AASP7
APHE8
AASP105

site_idAC3
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CA A 8003
ChainResidue
AASP7
AGLU106

site_idAC4
Number of Residues17
DetailsBINDING SITE FOR RESIDUE DGT A 7000
ChainResidue
AASP7
APHE8
AASP9
ATYR10
APHE11
ATYR12
AALA44
ATHR45
ATYR48
AARG51
AASP105
ALYS159
AHOH8601
AHOH8602
AHOH8622
AHOH8802
TDC604

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues184
DetailsDomain: {"description":"UmuC"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues1
DetailsActive site: {}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsBinding site: {}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues1
DetailsSite: {"description":"Substrate discrimination"}
ChainResidueDetails

240971

PDB entries from 2025-08-27

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