2R42
The Biochemical and Structural Basis for feedback Inhibition of Mevalonate Kinase and Isoprenoid Metabolism
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003729 | molecular_function | mRNA binding |
| A | 0004496 | molecular_function | mevalonate kinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005777 | cellular_component | peroxisome |
| A | 0005829 | cellular_component | cytosol |
| A | 0006695 | biological_process | cholesterol biosynthetic process |
| A | 0006720 | biological_process | isoprenoid metabolic process |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0016125 | biological_process | sterol metabolic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| A | 0017148 | biological_process | negative regulation of translation |
| A | 0019287 | biological_process | isopentenyl diphosphate biosynthetic process, mevalonate pathway |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0045540 | biological_process | regulation of cholesterol biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050728 | biological_process | negative regulation of inflammatory response |
| A | 1990825 | molecular_function | sequence-specific mRNA binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 500 |
| Chain | Residue |
| A | GLY144 |
| A | SER146 |
| A | ALA147 |
| A | GLU193 |
| A | ASP204 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE FPS A 400 |
| Chain | Residue |
| A | GLY140 |
| A | GLY142 |
| A | LEU143 |
| A | GLY144 |
| A | SER145 |
| A | SER146 |
| A | TYR149 |
| A | HOH502 |
| A | HOH539 |
| A | LEU53 |
| A | ASN55 |
| A | SER108 |
| A | SER135 |
Functional Information from PROSITE/UniProt
| site_id | PS00627 |
| Number of Residues | 12 |
| Details | GHMP_KINASES_ATP GHMP kinases putative ATP-binding domain. LPpGaGLGSSAA |
| Chain | Residue | Details |
| A | LEU137-ALA148 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor => ECO:0000250|UniProtKB:Q03426 |
| Chain | Residue | Details |
| A | SER146 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:Q03426 |
| Chain | Residue | Details |
| A | ASP204 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 7 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11877411, ECO:0007744|PDB:1KVK |
| Chain | Residue | Details |
| A | ASN55 | |
| A | ASN104 | |
| A | SER108 | |
| A | SER135 | |
| A | SER146 | |
| A | GLU193 | |
| A | LYS13 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11877411, ECO:0007744|PDB:1KVK, ECO:0007744|PDB:2R42 |
| Chain | Residue | Details |
| A | GLY140 |
