Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2R2D

Structure of a quorum-quenching lactonase (AiiB) from Agrobacterium tumefaciens

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
A	0102007	molecular_function	acyl-L-homoserine-lactone lactonohydrolase activity
B	0016787	molecular_function	hydrolase activity
B	0046872	molecular_function	metal ion binding
B	0102007	molecular_function	acyl-L-homoserine-lactone lactonohydrolase activity
C	0016787	molecular_function	hydrolase activity
C	0046872	molecular_function	metal ion binding
C	0102007	molecular_function	acyl-L-homoserine-lactone lactonohydrolase activity
D	0016787	molecular_function	hydrolase activity
D	0046872	molecular_function	metal ion binding
D	0102007	molecular_function	acyl-L-homoserine-lactone lactonohydrolase activity
E	0016787	molecular_function	hydrolase activity
E	0046872	molecular_function	metal ion binding
E	0102007	molecular_function	acyl-L-homoserine-lactone lactonohydrolase activity
F	0016787	molecular_function	hydrolase activity
F	0046872	molecular_function	metal ion binding
F	0102007	molecular_function	acyl-L-homoserine-lactone lactonohydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 277

Chain	Residue
A	ASP115
A	HIS116
A	ASP213
A	HIS259
A	PO4279

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 278

Chain	Residue
A	PO4279
A	HIS111
A	HIS113
A	HIS191
A	ASP213

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PO4 A 279

Chain	Residue
A	HIS111
A	HIS113
A	ASN114
A	ASP115
A	HIS116
A	HIS191
A	ASP213
A	TYR216
A	HIS259
A	ZN277
A	ZN278
A	GOL280
A	HOH326

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 277

Chain	Residue
B	ASP115
B	HIS116
B	ASP213
B	HIS259
B	PO4279

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 278

Chain	Residue
B	HIS111
B	HIS113
B	HIS191
B	ASP213
B	PO4279

site_id	AC6
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PO4 B 279

Chain	Residue
B	HIS111
B	HIS113
B	ASN114
B	ASP115
B	HIS116
B	HIS191
B	ASP213
B	TYR216
B	HIS259
B	ZN277
B	ZN278
B	GOL281
B	HOH350

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 B 280

Chain	Residue
B	HIS243
B	GLN246
B	TYR247
B	ARG251
B	HOH483

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN C 277

Chain	Residue
C	ASP115
C	HIS116
C	ASP213
C	HIS259
C	PO4279

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN C 278

Chain	Residue
C	HIS111
C	HIS113
C	HIS191
C	ASP213
C	PO4279

site_id	BC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PO4 C 279

Chain	Residue
C	HIS111
C	HIS113
C	ASN114
C	ASP115
C	HIS116
C	HIS191
C	ASP213
C	TYR216
C	HIS259
C	ZN277
C	ZN278
C	GOL281
C	HOH319

site_id	BC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 C 280

Chain	Residue
C	GLU175
C	ASN183
C	HIS243
C	GLN246
C	TYR247
C	SER250
C	ARG251
C	HOH314

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN D 277

Chain	Residue
D	ASP115
D	HIS116
D	ASP213
D	HIS259
D	PO4279

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN D 278

Chain	Residue
D	HIS111
D	HIS113
D	HIS191
D	ASP213
D	PO4279

site_id	BC5
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PO4 D 279

Chain	Residue
D	TYR216
D	HIS259
D	ZN277
D	ZN278
D	GOL280
D	HOH335
D	HIS111
D	HIS113
D	ASN114
D	ASP115
D	HIS116
D	HIS191
D	ASP213

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN E 277

Chain	Residue
E	ASP115
E	HIS116
E	ASP213
E	HIS259
E	PO4279

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN E 278

Chain	Residue
E	HIS111
E	HIS113
E	HIS191
E	ASP213
E	PO4279

site_id	BC8
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PO4 E 279

Chain	Residue
E	HIS111
E	HIS113
E	ASN114
E	ASP115
E	HIS116
E	HIS191
E	ASP213
E	TYR216
E	HIS259
E	ZN277
E	ZN278
E	GOL281
E	HOH347

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 E 280

Chain	Residue
E	HIS243
E	GLN246
E	TYR247
E	ARG251

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN F 277

Chain	Residue
F	ASP115
F	HIS116
F	ASP213
F	HIS259
F	PO4279

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN F 278

Chain	Residue
F	HIS111
F	HIS113
F	HIS191
F	ASP213
F	PO4279

site_id	CC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PO4 F 279

Chain	Residue
F	HIS111
F	HIS113
F	ASN114
F	ASP115
F	HIS116
F	HIS191
F	ASP213
F	TYR216
F	HIS259
F	ZN277
F	ZN278
F	GOL280
F	HOH442

site_id	CC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 280

Chain	Residue
A	ILE41
A	ASN114
A	ASP115
A	HIS259
A	PO4279
A	HOH450
A	HOH539
A	HOH555

site_id	CC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 281

Chain	Residue
A	SER266
A	TYR275
A	HOH387
A	HOH560
A	HOH561

site_id	CC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL A 282

Chain	Residue
A	HOH570
C	MET1

site_id	CC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL B 281

Chain	Residue
B	ILE41
B	ASP115
B	TYR216
B	HIS259
B	PO4279

site_id	CC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL B 282

Chain	Residue
B	ALA136
B	ARG140
B	HOH306

site_id	CC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL C 281

Chain	Residue
C	ILE13
C	ILE41
C	ASP115
C	TYR216
C	HIS259
C	PO4279

site_id	DC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL C 282

Chain	Residue
B	ASP233
B	ILE235
C	THR189
C	ASP233
C	GLY236
C	HOH541
C	HOH562
C	HOH574

site_id	DC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL D 280

Chain	Residue
D	ASN114
D	ASP115
D	PO4279
D	HOH365
D	HOH401
D	HOH419

site_id	DC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL E 281

Chain	Residue
E	ILE41
E	ASN114
E	ASP115
E	HIS259
E	PO4279
E	HOH371
E	HOH469
E	HOH471
E	HOH501

site_id	DC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL F 280

Chain	Residue
F	ILE13
F	ILE41
F	ASN114
F	ASP115
F	HIS259
F	PO4279
F	HOH358
F	HOH393
F	HOH446
F	HOH454

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	BINDING: BINDING => ECO:0000269\|PubMed:17900178

Chain	Residue	Details
A	HIS111
B	HIS191
B	ASP213
B	HIS259
C	HIS111
C	HIS113
C	HIS116
C	HIS191
C	ASP213
C	HIS259
D	HIS111
A	HIS113
D	HIS113
D	HIS116
D	HIS191
D	ASP213
D	HIS259
E	HIS111
E	HIS113
E	HIS116
E	HIS191
E	ASP213
A	HIS116
E	HIS259
F	HIS111
F	HIS113
F	HIS116
F	HIS191
F	ASP213
F	HIS259
A	HIS191
A	ASP213
A	HIS259
B	HIS111
B	HIS113
B	HIS116

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)