2QYM

crystal structure of unliganded PDE4C2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
A	0007165	biological_process	signal transduction
A	0008081	molecular_function	phosphoric diester hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN A 1

Chain	Residue
A	HIS286
A	HIS322
A	ASP323
A	ASP440
A	HOH558
A	HOH559

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 2

Chain	Residue
A	HOH561
A	HOH562
A	HOH563
A	ASP323
A	HOH558
A	HOH560

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Functional Information from PROSITE/UniProt

site_id	PS00126
Number of Residues	12
Details	PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDVdHpGvsNqF

Chain	Residue	Details
A	HIS322-PHE333

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000250|UniProtKB:Q07343

Chain	Residue	Details
A	HIS282

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q07343

Chain	Residue	Details
A	HIS282
A	ASP323
A	GLN491
A	PHE494

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site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:17727341, ECO:0007744|PDB:2QYM

Chain	Residue	Details
A	HIS286
A	HIS322
A	ASP440

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q3UEI1

Chain	Residue	Details
A	SER535

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