2QW9

Crystal structure of bovine hsc70 (1-394aa)in the apo state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0140662	molecular_function	ATP-dependent protein folding chaperone
B	0005524	molecular_function	ATP binding
B	0140662	molecular_function	ATP-dependent protein folding chaperone

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 1

Chain	Residue
A	GLU318
A	LYS328
A	PHE353
A	HOH400
B	ARG311
B	LEU349
B	ASP352
B	PHE353

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Functional Information from PROSITE/UniProt

site_id	PS00329
Number of Residues	14
Details	HSP70_2 Heat shock hsp70 proteins family signature 2. IFDLGGGTfdvSIL

Chain	Residue	Details
A	ILE197-LEU210

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site_id	PS00297
Number of Residues	8
Details	HSP70_1 Heat shock hsp70 proteins family signature 1. IDLGTTyS

Chain	Residue	Details
A	ILE9-SER16

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site_id	PS01036
Number of Residues	15
Details	HSP70_3 Heat shock hsp70 proteins family signature 3. IvLvGGsTRIPkIqK

Chain	Residue	Details
A	ILE334-LYS348

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING:

Chain	Residue	Details
A	GLY12
A	LYS71
B	GLY12
B	LYS71

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site_id	SWS_FT_FI2
Number of Residues	14
Details	BINDING: BINDING => ECO:0007744|PDB:2QWL, ECO:0007744|PDB:2QWM, ECO:0007744|PDB:2QWN, ECO:0007744|PDB:2QWO, ECO:0007744|PDB:2QWP, ECO:0007744|PDB:2QWQ

Chain	Residue	Details
A	GLY202
A	GLU268
A	LYS271
A	SER275
A	GLY339
B	THR14
B	TYR15
B	GLY202
B	GLU268
B	LYS271
B	SER275
B	GLY339
A	THR14
A	TYR15

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N-acetylserine => ECO:0000250|UniProtKB:P11142

Chain	Residue	Details
A	SER2
B	SER2

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site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P63017

Chain	Residue	Details
A	LYS108
A	LYS328
B	LYS108
B	LYS328

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site_id	SWS_FT_FI5
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P11142

Chain	Residue	Details
A	SER362
B	SER153
B	SER329
B	SER362
A	SER153
A	SER329

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P11142

Chain	Residue	Details
A	LYS246
B	LYS246

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site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P63017

Chain	Residue	Details
A	LYS319
B	LYS319

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	4
Details	M-CSA 656

Chain	Residue	Details
A	ASP10
A	LYS71	enhance reactivity
A	GLU175
A	ASP199

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site_id	MCSA2
Number of Residues	4
Details	M-CSA 656

Chain	Residue	Details
B	ASP10
B	LYS71	enhance reactivity
B	GLU175
B	ASP199

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