2QV6
GTP cyclohydrolase III from M. jannaschii (MJ0145) complexed with GTP and metal ions
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005525 | molecular_function | GTP binding |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016814 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines |
| A | 0043740 | molecular_function | GTP cyclohydrolase IIa activity |
| B | 0005525 | molecular_function | GTP binding |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016814 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines |
| B | 0043740 | molecular_function | GTP cyclohydrolase IIa activity |
| C | 0005525 | molecular_function | GTP binding |
| C | 0009058 | biological_process | biosynthetic process |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0016814 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines |
| C | 0043740 | molecular_function | GTP cyclohydrolase IIa activity |
| D | 0005525 | molecular_function | GTP binding |
| D | 0009058 | biological_process | biosynthetic process |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0016814 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines |
| D | 0043740 | molecular_function | GTP cyclohydrolase IIa activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K A 301 |
| Chain | Residue |
| A | ASP230 |
| A | GTP300 |
| C | ARG22 |
| C | GLU24 |
| C | HOH348 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 302 |
| Chain | Residue |
| A | NA303 |
| A | ASP138 |
| A | ILE139 |
| A | ASP183 |
| A | GTP300 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 303 |
| Chain | Residue |
| A | ASP138 |
| A | ASP183 |
| A | ASN184 |
| A | GTP300 |
| A | CA302 |
| A | HOH332 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K B 301 |
| Chain | Residue |
| B | ASP230 |
| B | GTP300 |
| D | ARG22 |
| D | GLU24 |
| D | HOH323 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 302 |
| Chain | Residue |
| B | ASP138 |
| B | ILE139 |
| B | ASP183 |
| B | GTP300 |
| B | NA303 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA B 303 |
| Chain | Residue |
| B | ASP138 |
| B | ASP183 |
| B | ASN184 |
| B | GTP300 |
| B | CA302 |
| B | HOH344 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K C 301 |
| Chain | Residue |
| A | ARG22 |
| A | GLU24 |
| C | ASP230 |
| C | GTP300 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA C 302 |
| Chain | Residue |
| C | ASP138 |
| C | ILE139 |
| C | ASP183 |
| C | GTP300 |
| C | NA303 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA C 303 |
| Chain | Residue |
| C | ASP138 |
| C | ASP183 |
| C | ASN184 |
| C | GTP300 |
| C | CA302 |
| C | HOH355 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K D 301 |
| Chain | Residue |
| B | ARG22 |
| B | GLU24 |
| B | HOH319 |
| D | ASP230 |
| D | GTP300 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA D 302 |
| Chain | Residue |
| D | ASP138 |
| D | ILE139 |
| D | ASP183 |
| D | GTP300 |
| D | NA303 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA D 303 |
| Chain | Residue |
| D | ASP138 |
| D | ASP183 |
| D | ASN184 |
| D | GTP300 |
| D | CA302 |
| D | HOH343 |
| site_id | BC4 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE GTP A 300 |
| Chain | Residue |
| A | HIS136 |
| A | ASP138 |
| A | ILE139 |
| A | ASN141 |
| A | ILE142 |
| A | THR143 |
| A | ILE180 |
| A | GLY182 |
| A | ASP183 |
| A | ASN184 |
| A | LYS213 |
| A | ARG237 |
| A | K301 |
| A | CA302 |
| A | NA303 |
| A | HOH337 |
| A | HOH338 |
| C | TYR12 |
| C | THR16 |
| C | GLU24 |
| C | LEU27 |
| C | GLN28 |
| C | ASP55 |
| C | GLN112 |
| C | HOH310 |
| C | HOH327 |
| site_id | BC5 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE GTP B 300 |
| Chain | Residue |
| B | ASN184 |
| B | LYS213 |
| B | ARG237 |
| B | K301 |
| B | CA302 |
| B | NA303 |
| B | HOH318 |
| B | HOH344 |
| B | HOH345 |
| D | TYR12 |
| D | THR16 |
| D | GLU24 |
| D | LEU27 |
| D | GLN28 |
| D | ASP55 |
| D | GLN112 |
| D | HOH313 |
| B | HIS136 |
| B | ASP138 |
| B | ILE139 |
| B | ASN140 |
| B | ASN141 |
| B | ILE142 |
| B | THR143 |
| B | ILE180 |
| B | GLY182 |
| B | ASP183 |
| site_id | BC6 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE GTP C 300 |
| Chain | Residue |
| A | TYR12 |
| A | THR16 |
| A | GLU24 |
| A | LEU27 |
| A | GLN28 |
| A | ASP55 |
| A | GLN112 |
| B | LYS206 |
| C | HIS136 |
| C | ASP138 |
| C | ILE139 |
| C | ASN141 |
| C | ILE142 |
| C | THR143 |
| C | ILE180 |
| C | GLY182 |
| C | ASP183 |
| C | ASN184 |
| C | LYS213 |
| C | ARG237 |
| C | K301 |
| C | CA302 |
| C | NA303 |
| C | HOH304 |
| C | HOH307 |
| C | HOH311 |
| C | HOH329 |
| C | HOH356 |
| site_id | BC7 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE GTP D 300 |
| Chain | Residue |
| A | LYS206 |
| B | TYR12 |
| B | THR16 |
| B | GLU24 |
| B | GLN28 |
| B | ASP55 |
| B | GLN112 |
| B | HOH319 |
| D | HIS136 |
| D | ASP138 |
| D | ILE139 |
| D | ASN141 |
| D | ILE142 |
| D | THR143 |
| D | ILE180 |
| D | GLY182 |
| D | ASP183 |
| D | ASN184 |
| D | LYS213 |
| D | ARG237 |
| D | K301 |
| D | CA302 |
| D | NA303 |
| D | HOH308 |
| D | HOH310 |
| D | HOH320 |
