2QT0
Human nicotinamide riboside kinase 1 in complex with nicotinamide riboside and an ATP analogue
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006741 | biological_process | NADP+ biosynthetic process |
| A | 0009435 | biological_process | NAD+ biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0019363 | biological_process | pyridine nucleotide biosynthetic process |
| A | 0019674 | biological_process | NAD+ metabolic process |
| A | 0034355 | biological_process | NAD+ biosynthetic process via the salvage pathway |
| A | 0046495 | biological_process | nicotinamide riboside metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050262 | molecular_function | ribosylnicotinamide kinase activity |
| A | 0061769 | molecular_function | nicotinate riboside kinase activity |
| A | 1901847 | biological_process | nicotinate metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 1001 |
| Chain | Residue |
| A | THR17 |
| A | ASP36 |
| A | HOH231 |
| A | HOH232 |
| A | ANP1102 |
| site_id | AC2 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE ANP A 1102 |
| Chain | Residue |
| A | LYS16 |
| A | THR17 |
| A | THR18 |
| A | ASP36 |
| A | ARG128 |
| A | ARG132 |
| A | TYR134 |
| A | LYS172 |
| A | SER173 |
| A | GLU174 |
| A | LEU177 |
| A | HOH231 |
| A | HOH232 |
| A | MG1001 |
| A | NNR1103 |
| A | THR12 |
| A | ASN13 |
| A | SER14 |
| A | GLY15 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE NNR A 1103 |
| Chain | Residue |
| A | THR12 |
| A | ASP36 |
| A | PHE39 |
| A | TYR55 |
| A | ASP56 |
| A | ARG129 |
| A | TYR134 |
| A | GLN135 |
| A | HOH208 |
| A | ANP1102 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"17914902","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QT0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17698003","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17914902","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2P0E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QG6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QL6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QSY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QSZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QT1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17914902","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QSY","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17698003","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17914902","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2P0E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QL6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QT1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17914902","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QT0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17914902","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2P0E","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17914902","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2P0E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QL6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QT1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17698003","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17914902","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2P0E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QG6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QSY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QSZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QT1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17698003","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17914902","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2P0E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QL6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QT0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
