2QSP

Bovine Hemoglobin at pH 5.7

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005344	molecular_function	oxygen carrier activity
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005833	cellular_component	hemoglobin complex
A	0015671	biological_process	oxygen transport
A	0019825	molecular_function	oxygen binding
A	0020037	molecular_function	heme binding
A	0031838	cellular_component	haptoglobin-hemoglobin complex
A	0046872	molecular_function	metal ion binding
A	0048821	biological_process	erythrocyte development
B	0005344	molecular_function	oxygen carrier activity
B	0005833	cellular_component	hemoglobin complex
B	0015671	biological_process	oxygen transport
B	0019825	molecular_function	oxygen binding
B	0020037	molecular_function	heme binding
B	0031721	molecular_function	hemoglobin alpha binding
B	0031838	cellular_component	haptoglobin-hemoglobin complex
B	0046872	molecular_function	metal ion binding
B	0048821	biological_process	erythrocyte development
C	0005344	molecular_function	oxygen carrier activity
C	0005506	molecular_function	iron ion binding
C	0005515	molecular_function	protein binding
C	0005833	cellular_component	hemoglobin complex
C	0015671	biological_process	oxygen transport
C	0019825	molecular_function	oxygen binding
C	0020037	molecular_function	heme binding
C	0031838	cellular_component	haptoglobin-hemoglobin complex
C	0046872	molecular_function	metal ion binding
C	0048821	biological_process	erythrocyte development
D	0005344	molecular_function	oxygen carrier activity
D	0005833	cellular_component	hemoglobin complex
D	0015671	biological_process	oxygen transport
D	0019825	molecular_function	oxygen binding
D	0020037	molecular_function	heme binding
D	0031721	molecular_function	hemoglobin alpha binding
D	0031838	cellular_component	haptoglobin-hemoglobin complex
D	0046872	molecular_function	metal ion binding
D	0048821	biological_process	erythrocyte development

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE HEM A 142

Chain	Residue
A	TYR42
A	PHE98
A	LEU101
A	LEU136
A	HOH222
A	HOH306
A	HOH316
A	PHE43
A	PHE46
A	HIS58
A	LYS61
A	LEU86
A	HIS87
A	LEU91
A	ASN97

---

site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE HEM B 146

Chain	Residue
B	THR37
B	PHE40
B	PHE41
B	HIS62
B	LYS65
B	LEU90
B	HIS91
B	LEU95
B	ASN101
B	PHE102
B	LEU105
B	LEU140
B	HOH164
B	HOH262
D	LYS7
D	HOH238

---

site_id	AC3
Number of Residues	16
Details	BINDING SITE FOR RESIDUE HEM C 142

Chain	Residue
C	TYR42
C	PHE43
C	HIS45
C	HIS58
C	LYS61
C	LEU83
C	HIS87
C	LEU91
C	ASN97
C	PHE98
C	LEU101
C	LEU136
C	HOH374
C	HOH397
C	HOH417
C	HOH426

---

site_id	AC4
Number of Residues	19
Details	BINDING SITE FOR RESIDUE HEM D 146

Chain	Residue
C	ALA4
D	THR37
D	PHE40
D	PHE41
D	HIS62
D	LYS65
D	SER69
D	HIS91
D	LEU95
D	ASN101
D	LEU140
D	HOH153
D	HOH168
D	HOH178
D	HOH210
D	HOH222
D	HOH236
D	HOH262
D	HOH324

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: distal binding residue

Chain	Residue	Details
B	HIS62
D	HIS62

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: proximal binding residue

Chain	Residue	Details
B	HIS91
D	HIS91

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P68871

Chain	Residue	Details
B	THR11
D	THR11
A	SER49
C	SER3
C	SER35
C	SER49

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P68871

Chain	Residue	Details
B	SER43
D	SER43
A	LYS40
C	LYS7
C	LYS11
C	LYS40

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P68871

Chain	Residue	Details
B	LYS58
B	LYS81
D	LYS58
D	LYS81

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: S-nitrosocysteine => ECO:0000250|UniProtKB:P68871

Chain	Residue	Details
B	CYS92
D	CYS92

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P01942

Chain	Residue	Details
A	SER102
A	SER124
A	SER138
C	SER102
C	SER124
C	SER138

---

site_id	SWS_FT_FI8
Number of Residues	6
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P01942

Chain	Residue	Details
A	THR108
A	THR134
A	THR137
C	THR108
C	THR134
C	THR137

---