2QRP
Glycogen Phosphorylase b in complex with (1R)-3'-(2-naphthyl)-spiro[1,5-anhydro-D-glucitol-1,5'-isoxazoline]
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004645 | molecular_function | 1,4-alpha-oligoglucan phosphorylase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0005977 | biological_process | glycogen metabolic process |
| A | 0005980 | biological_process | glycogen catabolic process |
| A | 0008184 | molecular_function | glycogen phosphorylase activity |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0098723 | cellular_component | skeletal muscle myofibril |
| A | 0102250 | molecular_function | linear malto-oligosaccharide phosphorylase activity |
| A | 0102499 | molecular_function | SHG alpha-glucan phosphorylase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE S06 A 998 |
| Chain | Residue |
| A | LEU136 |
| A | GLU672 |
| A | ALA673 |
| A | SER674 |
| A | GLY675 |
| A | HOH1042 |
| A | HOH1165 |
| A | HOH1447 |
| A | HOH1864 |
| A | ASN282 |
| A | ASN284 |
| A | PHE285 |
| A | HIS341 |
| A | HIS377 |
| A | ALA383 |
| A | ASN484 |
| A | TYR573 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DMS A 931 |
| Chain | Residue |
| A | TRP67 |
| A | ILE68 |
| A | ARG193 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS A 934 |
| Chain | Residue |
| A | GLU26 |
| A | ASN30 |
| A | PHE37 |
| A | ASP61 |
| A | HIS62 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE DMS A 936 |
| Chain | Residue |
| A | GLN219 |
| A | LYS294 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS A 937 |
| Chain | Residue |
| A | HIS201 |
| A | TRP215 |
| A | ARG351 |
| A | LEU356 |
| A | HOH1066 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS A 938 |
| Chain | Residue |
| A | ARG519 |
| A | GLU701 |
| A | GLU702 |
| A | ALA703 |
| A | GLY704 |
| A | HOH1152 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS A 939 |
| Chain | Residue |
| A | GLU706 |
| A | PHE708 |
| A | PHE709 |
| A | ARG786 |
| A | HOH1849 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS A 940 |
| Chain | Residue |
| A | ARG66 |
| A | LEU102 |
| A | ARG234 |
| A | ASN236 |
| A | ARG833 |
| A | HOH1103 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS A 942 |
| Chain | Residue |
| A | TYR548 |
| A | GLU552 |
| A | TYR553 |
| A | ARG649 |
| A | HOH1308 |
| A | HOH1695 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS A 945 |
| Chain | Residue |
| A | GLN264 |
| A | LEU267 |
| A | ASP268 |
| A | ASN270 |
| A | ASN274 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS A 946 |
| Chain | Residue |
| A | TYR553 |
| A | PHE644 |
| A | LEU645 |
| A | GLU646 |
| A | HOH1119 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DMS A 947 |
| Chain | Residue |
| A | TYR726 |
| A | HOH1064 |
| A | HOH1724 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DMS A 948 |
| Chain | Residue |
| A | ARG184 |
| A | THR197 |
| A | HOH1832 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DMS A 953 |
| Chain | Residue |
| A | ALA535 |
| A | PRO794 |
| A | THR798 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS A 959 |
| Chain | Residue |
| A | GLN408 |
| A | LEU411 |
| A | ASN412 |
| A | ALA415 |
| A | ASN595 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DMS A 972 |
| Chain | Residue |
| A | LEU271 |
| A | ASN274 |
| A | HOH1587 |
Functional Information from PROSITE/UniProt
| site_id | PS00102 |
| Number of Residues | 13 |
| Details | PHOSPHORYLASE Phosphorylase pyridoxal-phosphate attachment site. EASGtGnMKfmLN |
| Chain | Residue | Details |
| A | GLU672-ASN684 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P11217 |
| Chain | Residue | Details |
| A | ASP42 | |
| A | ARG309 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:3616621 |
| Chain | Residue | Details |
| A | TYR75 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | SITE: Involved in the association of subunits => ECO:0000303|PubMed:728424 |
| Chain | Residue | Details |
| A | CYS108 | |
| A | CYS142 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | SITE: Can be labeled by an AMP analog; may be involved in allosteric regulation => ECO:0000303|PubMed:728424 |
| Chain | Residue | Details |
| A | TYR155 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylserine => ECO:0000269|PubMed:3015680 |
| Chain | Residue | Details |
| A | SER1 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by PHK; in form phosphorylase A => ECO:0000250|UniProtKB:P11217 |
| Chain | Residue | Details |
| A | SER14 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P09812 |
| Chain | Residue | Details |
| A | TYR203 | |
| A | TYR226 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9WUB3 |
| Chain | Residue | Details |
| A | SER429 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q9WUB3 |
| Chain | Residue | Details |
| A | TYR472 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P09812 |
| Chain | Residue | Details |
| A | SER513 | |
| A | SER746 | |
| A | SER747 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000269|PubMed:7500360, ECO:0000269|PubMed:8976550, ECO:0007744|PDB:2PRI, ECO:0007744|PDB:2SKC, ECO:0007744|PDB:2SKD, ECO:0007744|PDB:2SKE |
| Chain | Residue | Details |
| A | LLP680 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1gpa |
| Chain | Residue | Details |
| A | ARG569 | |
| A | LYS568 | |
| A | THR676 | |
| A | LYS574 |
| site_id | MCSA1 |
| Number of Residues | 6 |
| Details | M-CSA 205 |
| Chain | Residue | Details |
| A | HIS377 | electrostatic stabiliser |
| A | LYS568 | electrostatic stabiliser |
| A | ARG569 | electrostatic stabiliser |
| A | LYS574 | electrostatic stabiliser |
| A | THR676 | electrostatic stabiliser |
| A | LLP680 | covalently attached |
